Environmental and biological monitoring of exposure to ethylenebisdithiocarbamate fungicides and ethylenethiourea
Exposure of workers to ethylenebisdithiocarbamates (EBDCs; maneb or mancozeb) in 29 potato farms was evaluated during the control of potato late blight. Concentrations of EBDCs and ethylenethiourea (ETU), an impurity and degradation product in EBDC formulations, in ambient air were evaluated during...
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| Veröffentlicht in: | British Journal of Industrial Medicine 1990-03, Vol.47 (3), p.203-206 |
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| creator | Kurttio, P Vartiainen, T Savolainen, K |
| description | Exposure of workers to ethylenebisdithiocarbamates (EBDCs; maneb or mancozeb) in 29 potato farms was evaluated during the control of potato late blight. Concentrations of EBDCs and ethylenethiourea (ETU), an impurity and degradation product in EBDC formulations, in ambient air were evaluated during pesticide application. Biological monitoring of exposure to EBDCs was carried out by measuring the concentrations of ETU, a metabolite of EBDCs, in urine for 22 days after the end of the exposure. The estimated inhaled doses of ETU and EBDCs during the average four hour application period were 0.07 and 1.8 micrograms/kg, respectively. Only 1-10% of ETU on the clothes reached the skin. The creatinine corrected concentrations of ETU in urine were 0.1-2.5 micrograms/mmol creatinine 24 hours after exposure ended. The estimated half life for eliminating ETU through the kidneys was close to 100 hours. These results indicate that the measurement of ETU in urine is suitable for biological monitoring of exposure to EBDCs. |
| doi_str_mv | 10.1136/oem.47.3.203 |
| format | Article |
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Concentrations of EBDCs and ethylenethiourea (ETU), an impurity and degradation product in EBDC formulations, in ambient air were evaluated during pesticide application. Biological monitoring of exposure to EBDCs was carried out by measuring the concentrations of ETU, a metabolite of EBDCs, in urine for 22 days after the end of the exposure. The estimated inhaled doses of ETU and EBDCs during the average four hour application period were 0.07 and 1.8 micrograms/kg, respectively. Only 1-10% of ETU on the clothes reached the skin. The creatinine corrected concentrations of ETU in urine were 0.1-2.5 micrograms/mmol creatinine 24 hours after exposure ended. The estimated half life for eliminating ETU through the kidneys was close to 100 hours. These results indicate that the measurement of ETU in urine is suitable for biological monitoring of exposure to EBDCs.</description><identifier>ISSN: 0007-1072</identifier><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.47.3.203</identifier><identifier>PMID: 2328226</identifier><identifier>CODEN: BJIMAG</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Agriculture ; Air Pollutants, Occupational - analysis ; Biological and medical sciences ; Breathing ; Chemical hazards ; Contact dermatitis ; Environmental Exposure ; Environmental Monitoring - methods ; Environmental Pollutants - analysis ; Ethylenethiourea - adverse effects ; Ethylenethiourea - analysis ; Ethylenethiourea - metabolism ; Excretion ; Fungicides ; Half lives ; Humans ; Imidazoles - adverse effects ; Male ; Maneb - adverse effects ; Maneb - urine ; Medical sciences ; Pesticides ; Pesticides, fertilizers and other agrochemicals toxicology ; Protective Clothing ; Skin ; Thiocarbamates - adverse effects ; Toxicology ; Urine ; Zineb - adverse effects ; Zineb - urine</subject><ispartof>British Journal of Industrial Medicine, 1990-03, Vol.47 (3), p.203-206</ispartof><rights>Copyright 1990 British Journal of Industrial Medicine</rights><rights>1990 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Mar 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b528t-ac33b43e7df3c6f41b768d2027662ce5c23209b818f2d3c1fcf3d00b7e4344aa3</citedby><cites>FETCH-LOGICAL-b528t-ac33b43e7df3c6f41b768d2027662ce5c23209b818f2d3c1fcf3d00b7e4344aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27726962$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27726962$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6861119$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2328226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurttio, P</creatorcontrib><creatorcontrib>Vartiainen, T</creatorcontrib><creatorcontrib>Savolainen, K</creatorcontrib><title>Environmental and biological monitoring of exposure to ethylenebisdithiocarbamate fungicides and ethylenethiourea</title><title>British Journal of Industrial Medicine</title><addtitle>Br J Ind Med</addtitle><description>Exposure of workers to ethylenebisdithiocarbamates (EBDCs; maneb or mancozeb) in 29 potato farms was evaluated during the control of potato late blight. Concentrations of EBDCs and ethylenethiourea (ETU), an impurity and degradation product in EBDC formulations, in ambient air were evaluated during pesticide application. Biological monitoring of exposure to EBDCs was carried out by measuring the concentrations of ETU, a metabolite of EBDCs, in urine for 22 days after the end of the exposure. The estimated inhaled doses of ETU and EBDCs during the average four hour application period were 0.07 and 1.8 micrograms/kg, respectively. Only 1-10% of ETU on the clothes reached the skin. The creatinine corrected concentrations of ETU in urine were 0.1-2.5 micrograms/mmol creatinine 24 hours after exposure ended. The estimated half life for eliminating ETU through the kidneys was close to 100 hours. These results indicate that the measurement of ETU in urine is suitable for biological monitoring of exposure to EBDCs.</description><subject>Agriculture</subject><subject>Air Pollutants, Occupational - analysis</subject><subject>Biological and medical sciences</subject><subject>Breathing</subject><subject>Chemical hazards</subject><subject>Contact dermatitis</subject><subject>Environmental Exposure</subject><subject>Environmental Monitoring - methods</subject><subject>Environmental Pollutants - analysis</subject><subject>Ethylenethiourea - adverse effects</subject><subject>Ethylenethiourea - analysis</subject><subject>Ethylenethiourea - metabolism</subject><subject>Excretion</subject><subject>Fungicides</subject><subject>Half lives</subject><subject>Humans</subject><subject>Imidazoles - adverse effects</subject><subject>Male</subject><subject>Maneb - adverse effects</subject><subject>Maneb - urine</subject><subject>Medical sciences</subject><subject>Pesticides</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Protective Clothing</subject><subject>Skin</subject><subject>Thiocarbamates - adverse effects</subject><subject>Toxicology</subject><subject>Urine</subject><subject>Zineb - adverse effects</subject><subject>Zineb - urine</subject><issn>0007-1072</issn><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUFvEzEQhS0EKmnhxhVpJZB6YYPt2bV3L0goFEpV4AIcuFi2104cdu3Udqr23-OSkMKFkzV63zzP00PoGcFzQoC9DmaaN3wOc4rhAZqRhuOa95Q9RDOMMa8J5vQxOk5pjTEBDvQIHVGgHaVshq7O_LWLwU_GZzlW0g-VcmEMS6fLOAXvcojOL6tgK3OzCWkbTZVDZfLqdjTeKJcGl1cuaBmVnGQ2ld36su0Gk37b_SHvoLIsn6BHVo7JPN2_J-jb-7Ovi_P68suHj4u3l7VqaZdrqQFUA4YPFjSzDVGcdQPFlDNGtWl1iYB71ZHO0gE0sdrCgLHipoGmkRJO0Jud72arJjPoEjDKUWyim2S8FUE68a_i3Uosw7UgGFoCUAxe7A1iuNqalMW6BPDlZkE4J7QhPe8L9WpH6RhSisYefiBY3PUjSj-i4QJE6afgz_--6gDvCyn6y70uU2nARum1SweMdYwQ0t_brFPp596Fc8p6Rote73SXsrk56DL-FIwDb8Xn7wvx7sfFRUc_nYu28Kc7Xk3r_wf4BRruwbY</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Kurttio, P</creator><creator>Vartiainen, T</creator><creator>Savolainen, K</creator><general>BMJ Publishing Group Ltd</general><general>British Medical Association</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>5PM</scope></search><sort><creationdate>19900301</creationdate><title>Environmental and biological monitoring of exposure to ethylenebisdithiocarbamate fungicides and ethylenethiourea</title><author>Kurttio, P ; Vartiainen, T ; Savolainen, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b528t-ac33b43e7df3c6f41b768d2027662ce5c23209b818f2d3c1fcf3d00b7e4344aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Agriculture</topic><topic>Air Pollutants, Occupational - analysis</topic><topic>Biological and medical sciences</topic><topic>Breathing</topic><topic>Chemical hazards</topic><topic>Contact dermatitis</topic><topic>Environmental Exposure</topic><topic>Environmental Monitoring - methods</topic><topic>Environmental Pollutants - analysis</topic><topic>Ethylenethiourea - adverse effects</topic><topic>Ethylenethiourea - analysis</topic><topic>Ethylenethiourea - metabolism</topic><topic>Excretion</topic><topic>Fungicides</topic><topic>Half lives</topic><topic>Humans</topic><topic>Imidazoles - adverse effects</topic><topic>Male</topic><topic>Maneb - adverse effects</topic><topic>Maneb - urine</topic><topic>Medical sciences</topic><topic>Pesticides</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Protective Clothing</topic><topic>Skin</topic><topic>Thiocarbamates - adverse effects</topic><topic>Toxicology</topic><topic>Urine</topic><topic>Zineb - adverse effects</topic><topic>Zineb - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurttio, P</creatorcontrib><creatorcontrib>Vartiainen, T</creatorcontrib><creatorcontrib>Savolainen, K</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British Journal of Industrial Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurttio, P</au><au>Vartiainen, T</au><au>Savolainen, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental and biological monitoring of exposure to ethylenebisdithiocarbamate fungicides and ethylenethiourea</atitle><jtitle>British Journal of Industrial Medicine</jtitle><addtitle>Br J Ind Med</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>47</volume><issue>3</issue><spage>203</spage><epage>206</epage><pages>203-206</pages><issn>0007-1072</issn><issn>1351-0711</issn><eissn>1470-7926</eissn><coden>BJIMAG</coden><abstract>Exposure of workers to ethylenebisdithiocarbamates (EBDCs; maneb or mancozeb) in 29 potato farms was evaluated during the control of potato late blight. Concentrations of EBDCs and ethylenethiourea (ETU), an impurity and degradation product in EBDC formulations, in ambient air were evaluated during pesticide application. Biological monitoring of exposure to EBDCs was carried out by measuring the concentrations of ETU, a metabolite of EBDCs, in urine for 22 days after the end of the exposure. The estimated inhaled doses of ETU and EBDCs during the average four hour application period were 0.07 and 1.8 micrograms/kg, respectively. Only 1-10% of ETU on the clothes reached the skin. The creatinine corrected concentrations of ETU in urine were 0.1-2.5 micrograms/mmol creatinine 24 hours after exposure ended. The estimated half life for eliminating ETU through the kidneys was close to 100 hours. These results indicate that the measurement of ETU in urine is suitable for biological monitoring of exposure to EBDCs.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>2328226</pmid><doi>10.1136/oem.47.3.203</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British Journal of Industrial Medicine, 1990-03, Vol.47 (3), p.203-206 |
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| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Agriculture Air Pollutants, Occupational - analysis Biological and medical sciences Breathing Chemical hazards Contact dermatitis Environmental Exposure Environmental Monitoring - methods Environmental Pollutants - analysis Ethylenethiourea - adverse effects Ethylenethiourea - analysis Ethylenethiourea - metabolism Excretion Fungicides Half lives Humans Imidazoles - adverse effects Male Maneb - adverse effects Maneb - urine Medical sciences Pesticides Pesticides, fertilizers and other agrochemicals toxicology Protective Clothing Skin Thiocarbamates - adverse effects Toxicology Urine Zineb - adverse effects Zineb - urine |
| title | Environmental and biological monitoring of exposure to ethylenebisdithiocarbamate fungicides and ethylenethiourea |
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