Arginine vasopressin deficiency and conivaptan (a V1a–V2 receptor antagonist) treatment reverses liver damage and fibrosis in rats with chronic portocaval anastomosis

Arginine vasopressin (AVP) is a naturally occurring hormone synthesized in the hypothalamus. AVP demonstrates pro‐fibrotic effects as it stimulates hepatic stellate cells to secrete transforming growth factor‐β (TGF‐β) and collagen. Previous work in liver cirrhotic (CCL4‐induced) hamsters demonstrat...

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Veröffentlicht in:	International journal of experimental pathology 2023-08, Vol.104 (4), p.209-222
Hauptverfasser:	Navarro‐Gonzalez, Yesenia Danyeli, Ventura‐Juarez, Javier, Muñoz‐Ortega, Martín Humberto, González‐Blas, Daniel, Calvillo‐Robedo, Argelia, Avila‐Blanco, Manuel‐Enrique, Valdez‐Urias, Fernando, Quintanar‐Stephano, Andrés
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Anastomosis Anastomosis, Surgical Animals Antidiuretic Hormone Receptor Antagonists - pharmacology Arginine arginine vasopressin Arginine Vasopressin - pharmacology Argipressin Argipressin receptors Body weight Body weight gain Collagen Collagen (type I) conivaptan Cricetinae cytokines Diabetes Insipidus, Neurogenic Fibrosis Gene expression Glycogen Glycogens Growth factors Hamsters Histology Hypoglycemia Hypothalamus Liver Liver Cirrhosis - drug therapy Liver diseases liver fibrosis Microenvironments Nodules Original Phenotypes Pituitary portocaval anastomosis Rats Receptors Receptors, Vasopressin - genetics Recovery of function Stellate cells Surgery Transforming growth factor-b Vasopressin
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