The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial

The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial

Low-carbohydrate high-fat (LCHF) diets can be just as effective as high-carbohydrate, lower-fat (HCLF) diets for improving cardiovascular disease risk markers. Few studies have compared the effects of the UK HCLF dietary guidelines with an LCHF diet on lipids and lipoprotein metabolism using high-th...

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Veröffentlicht in:Nutrients 2023-06, Vol.15 (13), p.3002
Hauptverfasser: McCullough, D, Harrison, T, Enright, K J, Amirabdollahian, F, Mazidi, M, Lane, K E, Stewart, C E, Davies, I G
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Amino acids
Biomarkers
Blood cholesterol
Carbohydrates
Cardiovascular diseases
Cardiovascular Diseases - prevention & control
Cholesterol
Energy metabolism
Ethylenediaminetetraacetic acid
Health risks
High carbohydrate diet
High density lipoprotein
High fat diet
Humans
Lipid metabolism
Lipids
Lipoproteins
Lipoproteins (very low density)
Lipoproteins, HDL
Lipoproteins, LDL
Lipoproteins, VLDL
Low carbohydrate diet
Low density lipoprotein
Low density lipoproteins
Low fat diet
Magnetic Resonance Spectroscopy
Medical research
Medicine, Experimental
Metabolites
NMR
NMR spectroscopy
Nuclear magnetic resonance
Nuclear magnetic resonance spectroscopy
Nutrient deficiency
Nutrition
Phospholipids
Physiological aspects
Requirements
Risk factors
Spectroscopy
Trans fatty acids
Triglycerides
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Zusammenfassung:Low-carbohydrate high-fat (LCHF) diets can be just as effective as high-carbohydrate, lower-fat (HCLF) diets for improving cardiovascular disease risk markers. Few studies have compared the effects of the UK HCLF dietary guidelines with an LCHF diet on lipids and lipoprotein metabolism using high-throughput NMR spectroscopy. This study aimed to explore the effect of an ad libitum 8-week LCHF diet compared to an HCLF diet on lipids and lipoprotein metabolism and CVD risk factors. For 8 weeks, = 16 adults were randomly assigned to follow either an LCHF ( = 8,
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15133002