AIF1 + CSF1R + MSCs, induced by TNF-α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver. Chronic inflammation is regarded as the major trait of primary liver cancer. However, the characteristics of endogenous MSCs in the inflammatory environment and...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2023-08, Vol.78 (2), p.434-451
Hauptverfasser:	Zong, Chen, Meng, Yan, Ye, Fei, Yang, Xue, Li, Rong, Jiang, Jinghua, Zhao, Qiudong, Gao, Lu, Han, Zhipeng, Wei, Lixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis - metabolism Inflammation - metabolism Liver Neoplasms - pathology Mesenchymal Stem Cells Original : Liver Cancer Rats Receptor Protein-Tyrosine Kinases Sirtuin 1 - metabolism Tumor Microenvironment Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
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