Maresin: Macrophage Mediator for Resolving Inflammation and Bridging Tissue Regeneration-A System-Based Preclinical Systematic Review
Maresins are lipid mediators derived from omega-3 fatty acids with anti-inflammatory and pro-resolving properties, capable of promoting tissue regeneration and potentially serving as a therapeutic agent for chronic inflammatory diseases. The aim of this review was to systematically investigate precl...
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| Veröffentlicht in: | International journal of molecular sciences 2023-07, Vol.24 (13), p.11012 |
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| creator | Liu, Wen-Chun Yang, Yu-Hsin Wang, Yu-Chin Chang, Wei-Ming Wang, Chin-Wei |
| description | Maresins are lipid mediators derived from omega-3 fatty acids with anti-inflammatory and pro-resolving properties, capable of promoting tissue regeneration and potentially serving as a therapeutic agent for chronic inflammatory diseases. The aim of this review was to systematically investigate preclinical and clinical studies on maresin to inform translational research. Two independent reviewers performed comprehensive searches with the term "Maresin (NOT) Review" on PubMed. A total of 137 studies were included and categorized into 11 human organ systems. Data pertinent to clinical translation were specifically extracted, including delivery methods, optimal dose response, and specific functional efficacy. Maresins generally exhibit efficacy in treating inflammatory diseases, attenuating inflammation, protecting organs, and promoting tissue regeneration, mostly in rodent preclinical models. The nervous system has the highest number of original studies (
= 25), followed by the cardiovascular system, digestive system, and respiratory system, each having the second highest number of studies (
= 18) in the field. Most studies considered systemic delivery with an optimal dose response for mouse animal models ranging from 4 to 25 μg/kg or 2 to 200 ng via intraperitoneal or intravenous injection respectively, whereas human in vitro studies ranged between 1 and 10 nM. Although there has been no human interventional clinical trial yet, the levels of MaR1 in human tissue fluid can potentially serve as biomarkers, including salivary samples for predicting the occurrence of cardiovascular diseases and periodontal diseases; plasma and synovial fluid levels of MaR1 can be associated with treatment response and defining pathotypes of rheumatoid arthritis. Maresins exhibit great potency in resolving disease inflammation and bridging tissue regeneration in preclinical models, and future translational development is warranted. |
| doi_str_mv | 10.3390/ijms241311012 |
| format | Article |
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= 25), followed by the cardiovascular system, digestive system, and respiratory system, each having the second highest number of studies (
= 18) in the field. Most studies considered systemic delivery with an optimal dose response for mouse animal models ranging from 4 to 25 μg/kg or 2 to 200 ng via intraperitoneal or intravenous injection respectively, whereas human in vitro studies ranged between 1 and 10 nM. Although there has been no human interventional clinical trial yet, the levels of MaR1 in human tissue fluid can potentially serve as biomarkers, including salivary samples for predicting the occurrence of cardiovascular diseases and periodontal diseases; plasma and synovial fluid levels of MaR1 can be associated with treatment response and defining pathotypes of rheumatoid arthritis. Maresins exhibit great potency in resolving disease inflammation and bridging tissue regeneration in preclinical models, and future translational development is warranted.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241311012</identifier><identifier>PMID: 37446190</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal models ; Animals ; Anti-Inflammatory Agents ; Cardiovascular diseases ; Cardiovascular system ; Chronic Disease ; Clinical trials ; Digestive system ; Docosahexaenoic Acids - pharmacology ; Docosahexaenoic Acids - therapeutic use ; Fatty acids ; Health aspects ; Human tissues ; Humans ; Hypotheses ; Inflammation ; Inflammation - drug therapy ; Inflammatory diseases ; Kinases ; Ligaments ; Lipids ; Macrophages ; Medical research ; Medicine, Experimental ; Mice ; Nervous system ; Omega-3 fatty acids ; Pain ; Pathogens ; Periodontal diseases ; Peritonitis ; Pharmacology ; Regeneration (physiology) ; Respiratory system ; Review ; Reviews ; Rheumatoid arthritis ; Rheumatoid factor ; Stem cells ; Synovial fluid ; Systematic review ; Temporomandibular joint disorders ; Tissue engineering ; Translation</subject><ispartof>International journal of molecular sciences, 2023-07, Vol.24 (13), p.11012</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-122dd0ceb092986877d40a2165dc4047a5bfa4880041b66040e5c6afc574fa6e3</citedby><cites>FETCH-LOGICAL-c483t-122dd0ceb092986877d40a2165dc4047a5bfa4880041b66040e5c6afc574fa6e3</cites><orcidid>0000-0001-9679-4121 ; 0000-0002-6899-4043</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341548/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341548/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37446190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Wen-Chun</creatorcontrib><creatorcontrib>Yang, Yu-Hsin</creatorcontrib><creatorcontrib>Wang, Yu-Chin</creatorcontrib><creatorcontrib>Chang, Wei-Ming</creatorcontrib><creatorcontrib>Wang, Chin-Wei</creatorcontrib><title>Maresin: Macrophage Mediator for Resolving Inflammation and Bridging Tissue Regeneration-A System-Based Preclinical Systematic Review</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Maresins are lipid mediators derived from omega-3 fatty acids with anti-inflammatory and pro-resolving properties, capable of promoting tissue regeneration and potentially serving as a therapeutic agent for chronic inflammatory diseases. The aim of this review was to systematically investigate preclinical and clinical studies on maresin to inform translational research. Two independent reviewers performed comprehensive searches with the term "Maresin (NOT) Review" on PubMed. A total of 137 studies were included and categorized into 11 human organ systems. Data pertinent to clinical translation were specifically extracted, including delivery methods, optimal dose response, and specific functional efficacy. Maresins generally exhibit efficacy in treating inflammatory diseases, attenuating inflammation, protecting organs, and promoting tissue regeneration, mostly in rodent preclinical models. The nervous system has the highest number of original studies (
= 25), followed by the cardiovascular system, digestive system, and respiratory system, each having the second highest number of studies (
= 18) in the field. Most studies considered systemic delivery with an optimal dose response for mouse animal models ranging from 4 to 25 μg/kg or 2 to 200 ng via intraperitoneal or intravenous injection respectively, whereas human in vitro studies ranged between 1 and 10 nM. Although there has been no human interventional clinical trial yet, the levels of MaR1 in human tissue fluid can potentially serve as biomarkers, including salivary samples for predicting the occurrence of cardiovascular diseases and periodontal diseases; plasma and synovial fluid levels of MaR1 can be associated with treatment response and defining pathotypes of rheumatoid arthritis. Maresins exhibit great potency in resolving disease inflammation and bridging tissue regeneration in preclinical models, and future translational development is warranted.</description><subject>Animal models</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular system</subject><subject>Chronic Disease</subject><subject>Clinical trials</subject><subject>Digestive system</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Docosahexaenoic Acids - therapeutic use</subject><subject>Fatty acids</subject><subject>Health aspects</subject><subject>Human tissues</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammatory diseases</subject><subject>Kinases</subject><subject>Ligaments</subject><subject>Lipids</subject><subject>Macrophages</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mice</subject><subject>Nervous system</subject><subject>Omega-3 fatty acids</subject><subject>Pain</subject><subject>Pathogens</subject><subject>Periodontal diseases</subject><subject>Peritonitis</subject><subject>Pharmacology</subject><subject>Regeneration (physiology)</subject><subject>Respiratory system</subject><subject>Review</subject><subject>Reviews</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Stem cells</subject><subject>Synovial fluid</subject><subject>Systematic review</subject><subject>Temporomandibular joint disorders</subject><subject>Tissue engineering</subject><subject>Translation</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1vEzEQhi0EoiVw5IpW4sJli7_Wu-GC0oqPSo1AUM7WxJ7dOtq1g70b1B_A_8ZpQ9QgZI088jzvjMceQl4yeibEnL516yFxyQRjlPFH5JRJzktKVf34gX9CnqW0ppQLXs2fkhNRS6nYnJ6S30uImJx_VyzBxLC5gQ6LJVoHY4hFm-0bptBvne-KS9_2MAwwuuAL8LY4j852u8i1S2nCjHboMd4B5aL4fptGHMpzSGiLrxFN77wz0O8DGTNZsnX46zl50kKf8MV-n5EfHz9cX3wur758urxYXJVGNmIsGefWUoMrOufzRjV1bSUFzlRljaSyhmrVgmwaSiVbKUUlxcooaE1VyxYUihl5f593M60GtAb9GKHXm-gGiLc6gNPHEe9udBe2mlEhWZUvMSNv9hli-DlhGvXgksG-B49hSpo3ouGSS8Uz-vofdB2m6HN_O0pJJWi2A9VBj9r5NuTCZpdUL-qqEayu78qe_YfKy-LgTPDYunx-JCjvBflTU4rYHppkVO8GRx8NTuZfPXyZA_13UsQfanu-_Q</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Liu, Wen-Chun</creator><creator>Yang, Yu-Hsin</creator><creator>Wang, Yu-Chin</creator><creator>Chang, Wei-Ming</creator><creator>Wang, Chin-Wei</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9679-4121</orcidid><orcidid>https://orcid.org/0000-0002-6899-4043</orcidid></search><sort><creationdate>20230701</creationdate><title>Maresin: Macrophage Mediator for Resolving Inflammation and Bridging Tissue Regeneration-A System-Based Preclinical Systematic Review</title><author>Liu, Wen-Chun ; Yang, Yu-Hsin ; Wang, Yu-Chin ; Chang, Wei-Ming ; Wang, Chin-Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-122dd0ceb092986877d40a2165dc4047a5bfa4880041b66040e5c6afc574fa6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular system</topic><topic>Chronic Disease</topic><topic>Clinical trials</topic><topic>Digestive system</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Docosahexaenoic Acids - therapeutic use</topic><topic>Fatty acids</topic><topic>Health aspects</topic><topic>Human tissues</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammatory diseases</topic><topic>Kinases</topic><topic>Ligaments</topic><topic>Lipids</topic><topic>Macrophages</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mice</topic><topic>Nervous system</topic><topic>Omega-3 fatty acids</topic><topic>Pain</topic><topic>Pathogens</topic><topic>Periodontal diseases</topic><topic>Peritonitis</topic><topic>Pharmacology</topic><topic>Regeneration (physiology)</topic><topic>Respiratory system</topic><topic>Review</topic><topic>Reviews</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Stem cells</topic><topic>Synovial fluid</topic><topic>Systematic review</topic><topic>Temporomandibular joint disorders</topic><topic>Tissue engineering</topic><topic>Translation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Wen-Chun</creatorcontrib><creatorcontrib>Yang, Yu-Hsin</creatorcontrib><creatorcontrib>Wang, Yu-Chin</creatorcontrib><creatorcontrib>Chang, Wei-Ming</creatorcontrib><creatorcontrib>Wang, Chin-Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Wen-Chun</au><au>Yang, Yu-Hsin</au><au>Wang, Yu-Chin</au><au>Chang, Wei-Ming</au><au>Wang, Chin-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maresin: Macrophage Mediator for Resolving Inflammation and Bridging Tissue Regeneration-A System-Based Preclinical Systematic Review</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>24</volume><issue>13</issue><spage>11012</spage><pages>11012-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Maresins are lipid mediators derived from omega-3 fatty acids with anti-inflammatory and pro-resolving properties, capable of promoting tissue regeneration and potentially serving as a therapeutic agent for chronic inflammatory diseases. The aim of this review was to systematically investigate preclinical and clinical studies on maresin to inform translational research. Two independent reviewers performed comprehensive searches with the term "Maresin (NOT) Review" on PubMed. A total of 137 studies were included and categorized into 11 human organ systems. Data pertinent to clinical translation were specifically extracted, including delivery methods, optimal dose response, and specific functional efficacy. Maresins generally exhibit efficacy in treating inflammatory diseases, attenuating inflammation, protecting organs, and promoting tissue regeneration, mostly in rodent preclinical models. The nervous system has the highest number of original studies (
= 25), followed by the cardiovascular system, digestive system, and respiratory system, each having the second highest number of studies (
= 18) in the field. Most studies considered systemic delivery with an optimal dose response for mouse animal models ranging from 4 to 25 μg/kg or 2 to 200 ng via intraperitoneal or intravenous injection respectively, whereas human in vitro studies ranged between 1 and 10 nM. Although there has been no human interventional clinical trial yet, the levels of MaR1 in human tissue fluid can potentially serve as biomarkers, including salivary samples for predicting the occurrence of cardiovascular diseases and periodontal diseases; plasma and synovial fluid levels of MaR1 can be associated with treatment response and defining pathotypes of rheumatoid arthritis. Maresins exhibit great potency in resolving disease inflammation and bridging tissue regeneration in preclinical models, and future translational development is warranted.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37446190</pmid><doi>10.3390/ijms241311012</doi><orcidid>https://orcid.org/0000-0001-9679-4121</orcidid><orcidid>https://orcid.org/0000-0002-6899-4043</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animal models Animals Anti-Inflammatory Agents Cardiovascular diseases Cardiovascular system Chronic Disease Clinical trials Digestive system Docosahexaenoic Acids - pharmacology Docosahexaenoic Acids - therapeutic use Fatty acids Health aspects Human tissues Humans Hypotheses Inflammation Inflammation - drug therapy Inflammatory diseases Kinases Ligaments Lipids Macrophages Medical research Medicine, Experimental Mice Nervous system Omega-3 fatty acids Pain Pathogens Periodontal diseases Peritonitis Pharmacology Regeneration (physiology) Respiratory system Review Reviews Rheumatoid arthritis Rheumatoid factor Stem cells Synovial fluid Systematic review Temporomandibular joint disorders Tissue engineering Translation |
| title | Maresin: Macrophage Mediator for Resolving Inflammation and Bridging Tissue Regeneration-A System-Based Preclinical Systematic Review |
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