The Cuprizone Mouse Model: A Comparative Study of Cuprizone Formulations from Different Manufacturers

The Cuprizone mouse model is widely used in studies on de- and remyelination. In the hands of different experimenters, the Cuprizone concentrations that lead to comparable levels of demyelination differ considerably. The reasons for this variability are unknown. In this study, we tested whether diff...

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Veröffentlicht in:	International journal of molecular sciences 2023-06, Vol.24 (13), p.10564
Hauptverfasser:	Beecken, Malena, Baumann, Louise, Vankriekelsvenne, Elise, Manzhula, Katerina, Greiner, Theresa, Heinig, Leo, Schauerte, Steffen, Kipp, Markus, Joost, Sarah
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Body Weight Comparative studies Copper Cuprizone Cuprizone - toxicity Demyelinating Diseases - chemically induced Demyelinating Diseases - pathology Demyelination Disease Models, Animal Glial fibrillary acidic protein Gliosis Intoxication Labeling Male Mice Mice, Inbred C57BL Myelin proteolipid protein Myelin Sheath - pathology Myelination Variability
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