Spectroscopic MRI-Based Biomarkers Predict Survival for Newly Diagnosed Glioblastoma in a Clinical Trial

Despite aggressive treatment, glioblastoma has a poor prognosis due to its infiltrative nature. Spectroscopic MRI-measured brain metabolites, particularly the choline to N-acetylaspartate ratio (Cho/NAA), better characterizes the extent of tumor infiltration. In a previous pilot trial (NCT03137888),...

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Veröffentlicht in:	Cancers 2023-07, Vol.15 (13), p.3524
Hauptverfasser:	Trivedi, Anuradha G, Ramesh, Karthik K, Huang, Vicki, Mellon, Eric A, Barker, Peter B, Kleinberg, Lawrence R, Weinberg, Brent D, Shu, Hui-Kuo G, Shim, Hyunsuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological markers Biomarkers Choline Clinical trials Collaboration Enrollments Glioblastoma Glioblastoma multiforme Magnetic resonance imaging Medical imaging Medical prognosis Metabolism Metastases N-Acetylaspartate Neuroimaging Patient outcomes Patients Radiation Radiation therapy Radiotherapy Review boards Statistical analysis Surgery Survival analysis Tumors
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