Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating

Herein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic nanoparticles (MNPs) with horseradish peroxidase (HRP) using biomimetic silica as an entrapment matrix was optimized to obtain...

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Veröffentlicht in:	ACS nano 2023-07, Vol.17 (13), p.12358-12373
Hauptverfasser:	Torres-Herrero, Beatriz, Armenia, Ilaria, Alleva, Maria, Asín, Laura, Correa, Sonali, Ortiz, Cecilia, Fernández-Afonso, Yilian, Gutiérrez, Lucía, de la Fuente, Jesús M., Betancor, Lorena, Grazú, Valeria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Heating Humans Magnetic Fields Magnetic Phenomena Nanoparticles Neoplasms - drug therapy Prodrugs - pharmacology Prodrugs - therapeutic use Silicon Dioxide
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