Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice

Background and aimsThe gastric epithelium undergoes continuous turnover. Corpus epithelial stem cells located in the gastric isthmus serve as a source of tissue self-renewal. We recently identified the transcription factor Mist1 as a marker for this corpus stem cell population that can give rise to...

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Veröffentlicht in:	Gut 2021-04, Vol.70 (4), p.654-665
Hauptverfasser:	Nienhüser, Henrik, Kim, Woosook, Malagola, Ermanno, Ruan, Tuo, Valenti, Giovanni, Middelhoff, Moritz, Bass, Adam, Der, Channing J, Hayakawa, Yoku, Wang, Timothy C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Animal models Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Cell culture Cell Proliferation Cell self-renewal Chief Cells, Gastric - metabolism Disease Epithelial Cells - metabolism Epithelium gastric and duodenal ulcers Gastric cancer Gastric glands Gastric Mucosa - metabolism helicobacter felis Inflammation Inflammation - metabolism intestinal stem cell Laboratories Lymphoid cells Mice Mice, Knockout Stem cell transplantation Stem cells Stem Cells - metabolism Stomach Stomach Ulcer - metabolism Transcription factors Ulcers Wnt protein Wnt Signaling Pathway Wound Healing
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