Rare coding variants in CHRNB2 reduce the likelihood of smoking

Human genetic studies of smoking behavior have been thus far largely limited to common variants. Studying rare coding variants has the potential to identify drug targets. We performed an exome-wide association study of smoking phenotypes in up to 749,459 individuals and discovered a protective assoc...

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Veröffentlicht in:	Nature genetics 2023-07, Vol.55 (7), p.1138-1148
Hauptverfasser:	Rajagopal, Veera M., Watanabe, Kyoko, Mbatchou, Joelle, Ayer, Ariane, Quon, Peter, Sharma, Deepika, Kessler, Michael D., Praveen, Kavita, Gelfman, Sahar, Parikshak, Neelroop, Otto, Jacqueline M., Bao, Suying, Chim, Shek Man, Pavlopoulos, Elias, Avbersek, Andreja, Kapoor, Manav, Chen, Esteban, Jones, Marcus B., Leblanc, Michelle, Emberson, Jonathan, Collins, Rory, Torres, Jason, Morales, Pablo Kuri, Tapia-Conyer, Roberto, Alegre, Jesus, Berumen, Jaime, Shuldiner, Alan R., Balasubramanian, Suganthi, Abecasis, Gonçalo R., Kang, Hyun M., Marchini, Jonathan, Stahl, Eli A., Jorgenson, Eric, Sanchez, Robert, Liedtke, Wolfgang, Anderson, Matthew, Cantor, Michael, Lederer, David, Baras, Aris, Coppola, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/22 45/23 45/43 45/56 631/154 631/208/1515 631/208/457 Addictions Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Chronic obstructive pulmonary disease Drug self-administration Gene Function Genealogy Genes Genomes Genotype & phenotype Health behavior Human Genetics Neural coding Nicotine Phenotypes Smoking Target recognition Therapeutic targets
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