Effect of trabeculectomy on the rate of progression of visual field damage
Objectives This study quantifies the effect of trabeculectomy on the rate of progression (RoP) of visual field (VF) damage utilising pre- and post-operative visual function as the outcome instead of surrogate outcomes of success. Methods Clinical and VF data from 199 sequential patients who underwen...
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| Veröffentlicht in: | Eye (London) 2023-07, Vol.37 (10), p.2145-2150 |
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| creator | Koenig, Susanna Friederike Montesano, Giovanni Fang, Clarissa Ern Hui Crabb, David Paul Jayaram, Hari Clarke, Jonathan |
| description | Objectives
This study quantifies the effect of trabeculectomy on the rate of progression (RoP) of visual field (VF) damage utilising pre- and post-operative visual function as the outcome instead of surrogate outcomes of success.
Methods
Clinical and VF data from 199 sequential patients who underwent trabeculectomy between 2015 and 2016 were extracted from the network of sites of Moorfields Eye Hospital NHS Foundation Trust. Of these, we analysed 80 eyes of 74 patients who met our inclusion criteria of at least three reliable VFs before and after surgery (false positive rate |
| doi_str_mv | 10.1038/s41433-022-02312-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10333233</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2753317021</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-f7282ba2a3dbed1935d13fdf7db6f1919fb36efbde85e28562027bc1929dc0e93</originalsourceid><addsrcrecordid>eNp9UU1LxDAQDaLouvoHPEjBi5dqMunnSWTxE8GLgreQNpO10jZr0gr77x1dvw8ehmTy3ryZyWNsT_AjwWVxHBKRSBlzAAopIF6usYlI8ixOkzRZZxNepjwGgIctth3CE-cE5nyTbcmMLjkUE3Z9Zi3WQ-RsNHhdYT22lLpuGbk-Gh4x8nrAN3Th3dxjCA29U_rShFG3kW2wNZHRnZ7jDtuwug24-3FO2f352d3sMr65vbiand7EdZKnQ2ypL1QatDQVGlHK1Ahpjc1NlVlRitJWMkNbGSxShCLNgENe1aKE0tQcSzllJyvdxVh1aGrsafJWLXzTab9UTjfqN9I3j2ruXhR9mpRAMWWHHwrePY8YBtU1oca21T26MSjIUylFzkEQ9eAP9cmNvqf9FBSSaDxJgFiwYtXeheDRfk0j-FvbQq28UuSVevdKLalo_-ceXyWf5hBBrgiBoH6O_rv3P7Kv4OGgyg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2835330442</pqid></control><display><type>article</type><title>Effect of trabeculectomy on the rate of progression of visual field damage</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>PubMed Central</source><creator>Koenig, Susanna Friederike ; Montesano, Giovanni ; Fang, Clarissa Ern Hui ; Crabb, David Paul ; Jayaram, Hari ; Clarke, Jonathan</creator><creatorcontrib>Koenig, Susanna Friederike ; Montesano, Giovanni ; Fang, Clarissa Ern Hui ; Crabb, David Paul ; Jayaram, Hari ; Clarke, Jonathan</creatorcontrib><description>Objectives
This study quantifies the effect of trabeculectomy on the rate of progression (RoP) of visual field (VF) damage utilising pre- and post-operative visual function as the outcome instead of surrogate outcomes of success.
Methods
Clinical and VF data from 199 sequential patients who underwent trabeculectomy between 2015 and 2016 were extracted from the network of sites of Moorfields Eye Hospital NHS Foundation Trust. Of these, we analysed 80 eyes of 74 patients who met our inclusion criteria of at least three reliable VFs before and after surgery (false positive rate <15%). The change in mean RoP (dB/year) was tested using point-wise sensitivity values through a mixed effect model with random effects on both intercepts and slopes. A broken-stick regression of sensitivity over time, with a breakpoint at the day of surgery, modelled the individual change in RoP.
Results
We analysed 10 [9,12] VFs per subject (Median [Interquartile Range]). At surgery, the age was 67 [57, 72] years, mean deviation was −10.84 [−14.7, −5.6] dB and the IOP was 18 [15, 20] mmHg. One year after surgery, the IOP was 10 [8,13] mmHg (
p
= 0.002). Mean RoP before surgery was −0.94 [−1.20, −0.69] dB/year (Mean [95% credible intervals]) and it was slowed down by 0.62 [0.26, 0.97] dB/year (
p
< 0.001) after surgery.
Conclusions
Trabeculectomy leads to a significant reduction in the RoP of VF loss postoperatively.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-022-02312-y</identifier><identifier>PMID: 36477728</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/409 ; 692/699/3161/3172 ; Disease Progression ; Humans ; Intraocular Pressure ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Ophthalmology ; Patients ; Pharmaceutical Sciences/Technology ; Retrospective Studies ; Surgery ; Surgical Oncology ; Tonometry, Ocular ; Trabeculectomy ; Visual field ; Visual Fields ; Visual perception</subject><ispartof>Eye (London), 2023-07, Vol.37 (10), p.2145-2150</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-f7282ba2a3dbed1935d13fdf7db6f1919fb36efbde85e28562027bc1929dc0e93</citedby><cites>FETCH-LOGICAL-c475t-f7282ba2a3dbed1935d13fdf7db6f1919fb36efbde85e28562027bc1929dc0e93</cites><orcidid>0000-0002-7266-7117 ; 0000-0003-1998-0670 ; 0000-0002-3199-0276 ; 0000-0002-9780-6216</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333233/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333233/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36477728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koenig, Susanna Friederike</creatorcontrib><creatorcontrib>Montesano, Giovanni</creatorcontrib><creatorcontrib>Fang, Clarissa Ern Hui</creatorcontrib><creatorcontrib>Crabb, David Paul</creatorcontrib><creatorcontrib>Jayaram, Hari</creatorcontrib><creatorcontrib>Clarke, Jonathan</creatorcontrib><title>Effect of trabeculectomy on the rate of progression of visual field damage</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Objectives
This study quantifies the effect of trabeculectomy on the rate of progression (RoP) of visual field (VF) damage utilising pre- and post-operative visual function as the outcome instead of surrogate outcomes of success.
Methods
Clinical and VF data from 199 sequential patients who underwent trabeculectomy between 2015 and 2016 were extracted from the network of sites of Moorfields Eye Hospital NHS Foundation Trust. Of these, we analysed 80 eyes of 74 patients who met our inclusion criteria of at least three reliable VFs before and after surgery (false positive rate <15%). The change in mean RoP (dB/year) was tested using point-wise sensitivity values through a mixed effect model with random effects on both intercepts and slopes. A broken-stick regression of sensitivity over time, with a breakpoint at the day of surgery, modelled the individual change in RoP.
Results
We analysed 10 [9,12] VFs per subject (Median [Interquartile Range]). At surgery, the age was 67 [57, 72] years, mean deviation was −10.84 [−14.7, −5.6] dB and the IOP was 18 [15, 20] mmHg. One year after surgery, the IOP was 10 [8,13] mmHg (
p
= 0.002). Mean RoP before surgery was −0.94 [−1.20, −0.69] dB/year (Mean [95% credible intervals]) and it was slowed down by 0.62 [0.26, 0.97] dB/year (
p
< 0.001) after surgery.
Conclusions
Trabeculectomy leads to a significant reduction in the RoP of VF loss postoperatively.</description><subject>692/308/409</subject><subject>692/699/3161/3172</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tonometry, Ocular</subject><subject>Trabeculectomy</subject><subject>Visual field</subject><subject>Visual Fields</subject><subject>Visual perception</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9UU1LxDAQDaLouvoHPEjBi5dqMunnSWTxE8GLgreQNpO10jZr0gr77x1dvw8ehmTy3ryZyWNsT_AjwWVxHBKRSBlzAAopIF6usYlI8ixOkzRZZxNepjwGgIctth3CE-cE5nyTbcmMLjkUE3Z9Zi3WQ-RsNHhdYT22lLpuGbk-Gh4x8nrAN3Th3dxjCA29U_rShFG3kW2wNZHRnZ7jDtuwug24-3FO2f352d3sMr65vbiand7EdZKnQ2ypL1QatDQVGlHK1Ahpjc1NlVlRitJWMkNbGSxShCLNgENe1aKE0tQcSzllJyvdxVh1aGrsafJWLXzTab9UTjfqN9I3j2ruXhR9mpRAMWWHHwrePY8YBtU1oca21T26MSjIUylFzkEQ9eAP9cmNvqf9FBSSaDxJgFiwYtXeheDRfk0j-FvbQq28UuSVevdKLalo_-ceXyWf5hBBrgiBoH6O_rv3P7Kv4OGgyg</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Koenig, Susanna Friederike</creator><creator>Montesano, Giovanni</creator><creator>Fang, Clarissa Ern Hui</creator><creator>Crabb, David Paul</creator><creator>Jayaram, Hari</creator><creator>Clarke, Jonathan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7266-7117</orcidid><orcidid>https://orcid.org/0000-0003-1998-0670</orcidid><orcidid>https://orcid.org/0000-0002-3199-0276</orcidid><orcidid>https://orcid.org/0000-0002-9780-6216</orcidid></search><sort><creationdate>20230701</creationdate><title>Effect of trabeculectomy on the rate of progression of visual field damage</title><author>Koenig, Susanna Friederike ; Montesano, Giovanni ; Fang, Clarissa Ern Hui ; Crabb, David Paul ; Jayaram, Hari ; Clarke, Jonathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-f7282ba2a3dbed1935d13fdf7db6f1919fb36efbde85e28562027bc1929dc0e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>692/308/409</topic><topic>692/699/3161/3172</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tonometry, Ocular</topic><topic>Trabeculectomy</topic><topic>Visual field</topic><topic>Visual Fields</topic><topic>Visual perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koenig, Susanna Friederike</creatorcontrib><creatorcontrib>Montesano, Giovanni</creatorcontrib><creatorcontrib>Fang, Clarissa Ern Hui</creatorcontrib><creatorcontrib>Crabb, David Paul</creatorcontrib><creatorcontrib>Jayaram, Hari</creatorcontrib><creatorcontrib>Clarke, Jonathan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koenig, Susanna Friederike</au><au>Montesano, Giovanni</au><au>Fang, Clarissa Ern Hui</au><au>Crabb, David Paul</au><au>Jayaram, Hari</au><au>Clarke, Jonathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of trabeculectomy on the rate of progression of visual field damage</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>37</volume><issue>10</issue><spage>2145</spage><epage>2150</epage><pages>2145-2150</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Objectives
This study quantifies the effect of trabeculectomy on the rate of progression (RoP) of visual field (VF) damage utilising pre- and post-operative visual function as the outcome instead of surrogate outcomes of success.
Methods
Clinical and VF data from 199 sequential patients who underwent trabeculectomy between 2015 and 2016 were extracted from the network of sites of Moorfields Eye Hospital NHS Foundation Trust. Of these, we analysed 80 eyes of 74 patients who met our inclusion criteria of at least three reliable VFs before and after surgery (false positive rate <15%). The change in mean RoP (dB/year) was tested using point-wise sensitivity values through a mixed effect model with random effects on both intercepts and slopes. A broken-stick regression of sensitivity over time, with a breakpoint at the day of surgery, modelled the individual change in RoP.
Results
We analysed 10 [9,12] VFs per subject (Median [Interquartile Range]). At surgery, the age was 67 [57, 72] years, mean deviation was −10.84 [−14.7, −5.6] dB and the IOP was 18 [15, 20] mmHg. One year after surgery, the IOP was 10 [8,13] mmHg (
p
= 0.002). Mean RoP before surgery was −0.94 [−1.20, −0.69] dB/year (Mean [95% credible intervals]) and it was slowed down by 0.62 [0.26, 0.97] dB/year (
p
< 0.001) after surgery.
Conclusions
Trabeculectomy leads to a significant reduction in the RoP of VF loss postoperatively.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>36477728</pmid><doi>10.1038/s41433-022-02312-y</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7266-7117</orcidid><orcidid>https://orcid.org/0000-0003-1998-0670</orcidid><orcidid>https://orcid.org/0000-0002-3199-0276</orcidid><orcidid>https://orcid.org/0000-0002-9780-6216</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye (London), 2023-07, Vol.37 (10), p.2145-2150 |
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| source | MEDLINE; SpringerLink Journals; PubMed Central |
| subjects | 692/308/409 692/699/3161/3172 Disease Progression Humans Intraocular Pressure Laboratory Medicine Medicine Medicine & Public Health Ophthalmology Patients Pharmaceutical Sciences/Technology Retrospective Studies Surgery Surgical Oncology Tonometry, Ocular Trabeculectomy Visual field Visual Fields Visual perception |
| title | Effect of trabeculectomy on the rate of progression of visual field damage |
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