Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines
Depression and obesity are both common disorders currently affecting public health, frequently occurring simultaneously within individuals, and the relationship between these disorders is bidirectional. The association between obesity and depression is highly co-morbid and tends to significantly exa...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2023-06, Vol.15 (12), p.5917-5950 |
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| creator | Fu, Xiying Wang, Yicun Zhao, Fangyi Cui, Ranji Xie, Wei Liu, Qianqian Yang, Wei |
| description | Depression and obesity are both common disorders currently affecting public health, frequently occurring simultaneously within individuals, and the relationship between these disorders is bidirectional. The association between obesity and depression is highly co-morbid and tends to significantly exacerbate metabolic and related depressive symptoms. However, the neural mechanism under the mutual control of obesity and depression is largely inscrutable. This review focuses particularly on alterations in systems that may mechanistically explain the
homeostatic regulation of the obesity and depression link, such as immune-inflammatory activation, gut microbiota, neuroplasticity, HPA axis dysregulation as well as neuroendocrine regulators of energy metabolism including adipocytokines and lipokines. In addition, the review summarizes potential and future treatments for obesity and depression and raises several questions that need to be answered in future research. This review will provide a comprehensive description and localization of the biological connection between obesity and depression to better understand the co-morbidity of obesity and depression. |
| doi_str_mv | 10.18632/aging.204847 |
| format | Article |
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homeostatic regulation of the obesity and depression link, such as immune-inflammatory activation, gut microbiota, neuroplasticity, HPA axis dysregulation as well as neuroendocrine regulators of energy metabolism including adipocytokines and lipokines. In addition, the review summarizes potential and future treatments for obesity and depression and raises several questions that need to be answered in future research. This review will provide a comprehensive description and localization of the biological connection between obesity and depression to better understand the co-morbidity of obesity and depression.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.204847</identifier><identifier>PMID: 37387537</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Adipokines - metabolism ; Brain - metabolism ; Depression - metabolism ; Humans ; Hypothalamo-Hypophyseal System - metabolism ; Obesity - metabolism ; Pituitary-Adrenal System - metabolism ; Review</subject><ispartof>Aging (Albany, NY.), 2023-06, Vol.15 (12), p.5917-5950</ispartof><rights>Copyright: © 2023 Fu et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-6830230163f85655ec57981680cd175b07032875f1a62be4c76693df3d310ef73</citedby><cites>FETCH-LOGICAL-c388t-6830230163f85655ec57981680cd175b07032875f1a62be4c76693df3d310ef73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333059/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333059/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37387537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Xiying</creatorcontrib><creatorcontrib>Wang, Yicun</creatorcontrib><creatorcontrib>Zhao, Fangyi</creatorcontrib><creatorcontrib>Cui, Ranji</creatorcontrib><creatorcontrib>Xie, Wei</creatorcontrib><creatorcontrib>Liu, Qianqian</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><title>Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>Depression and obesity are both common disorders currently affecting public health, frequently occurring simultaneously within individuals, and the relationship between these disorders is bidirectional. The association between obesity and depression is highly co-morbid and tends to significantly exacerbate metabolic and related depressive symptoms. However, the neural mechanism under the mutual control of obesity and depression is largely inscrutable. This review focuses particularly on alterations in systems that may mechanistically explain the
homeostatic regulation of the obesity and depression link, such as immune-inflammatory activation, gut microbiota, neuroplasticity, HPA axis dysregulation as well as neuroendocrine regulators of energy metabolism including adipocytokines and lipokines. In addition, the review summarizes potential and future treatments for obesity and depression and raises several questions that need to be answered in future research. This review will provide a comprehensive description and localization of the biological connection between obesity and depression to better understand the co-morbidity of obesity and depression.</description><subject>Adipokines - metabolism</subject><subject>Brain - metabolism</subject><subject>Depression - metabolism</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Obesity - metabolism</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Review</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkTtPwzAUhS0EoqUwsqKMLCl2bvwIC0IVL6kSAzAwWY7jpIbELnGC1H9P1JfKdF-fzj3SQeiS4CkRDJIbVVlXTROcipQfoTHJUhqnVGTHB_0InYXwhTGjNGWnaAQcBKfAx-jzbaFaU0S59bWvrFZ11Bi9UM6GJkS-jAqzbE0I1rtIuSLyuQm2W91Gpdf9AAzbwi79t3UmrIF6N52jk1LVwVxs6wR9PD68z57j-evTy-x-HmsQoouZAJwAJgxKQQd_RlOeCcIE1gXhNMccQzKYLYliSW5SzRnLoCihAIJNyWGC7ja6yz5vTKGN61pVy2VrG9WupFdW_r84u5CV_5UEAwCm2aBwvVVo_U9vQicbG7Spa-WM74NMBCR0eCvIgMYbVLc-hNaU-z8Ey3Uecp2H3OQx8FeH5vb0LgD4A0z0h9c</recordid><startdate>20230629</startdate><enddate>20230629</enddate><creator>Fu, Xiying</creator><creator>Wang, Yicun</creator><creator>Zhao, Fangyi</creator><creator>Cui, Ranji</creator><creator>Xie, Wei</creator><creator>Liu, Qianqian</creator><creator>Yang, Wei</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230629</creationdate><title>Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines</title><author>Fu, Xiying ; Wang, Yicun ; Zhao, Fangyi ; Cui, Ranji ; Xie, Wei ; Liu, Qianqian ; Yang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-6830230163f85655ec57981680cd175b07032875f1a62be4c76693df3d310ef73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adipokines - metabolism</topic><topic>Brain - metabolism</topic><topic>Depression - metabolism</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Obesity - metabolism</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Review</topic><toplevel>online_resources</toplevel><creatorcontrib>Fu, Xiying</creatorcontrib><creatorcontrib>Wang, Yicun</creatorcontrib><creatorcontrib>Zhao, Fangyi</creatorcontrib><creatorcontrib>Cui, Ranji</creatorcontrib><creatorcontrib>Xie, Wei</creatorcontrib><creatorcontrib>Liu, Qianqian</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Xiying</au><au>Wang, Yicun</au><au>Zhao, Fangyi</au><au>Cui, Ranji</au><au>Xie, Wei</au><au>Liu, Qianqian</au><au>Yang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2023-06-29</date><risdate>2023</risdate><volume>15</volume><issue>12</issue><spage>5917</spage><epage>5950</epage><pages>5917-5950</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>Depression and obesity are both common disorders currently affecting public health, frequently occurring simultaneously within individuals, and the relationship between these disorders is bidirectional. The association between obesity and depression is highly co-morbid and tends to significantly exacerbate metabolic and related depressive symptoms. However, the neural mechanism under the mutual control of obesity and depression is largely inscrutable. This review focuses particularly on alterations in systems that may mechanistically explain the
homeostatic regulation of the obesity and depression link, such as immune-inflammatory activation, gut microbiota, neuroplasticity, HPA axis dysregulation as well as neuroendocrine regulators of energy metabolism including adipocytokines and lipokines. In addition, the review summarizes potential and future treatments for obesity and depression and raises several questions that need to be answered in future research. This review will provide a comprehensive description and localization of the biological connection between obesity and depression to better understand the co-morbidity of obesity and depression.</abstract><cop>United States</cop><pub>Impact Journals</pub><pmid>37387537</pmid><doi>10.18632/aging.204847</doi><tpages>34</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adipokines - metabolism Brain - metabolism Depression - metabolism Humans Hypothalamo-Hypophyseal System - metabolism Obesity - metabolism Pituitary-Adrenal System - metabolism Review |
| title | Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines |
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