Primary Effusion Lymphoma-like ATL Developing during Hemodialysis
We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along...
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| Veröffentlicht in: | Internal Medicine 2023/06/15, Vol.62(12), pp.1807-1811 |
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| container_title | Internal Medicine |
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| creator | Masaki, Miharu Okushi, Yuki Saito, Atsushi Fukuda, Akihiro Yamada, Sohsuke Mizuta, Shuichi Masaki, Yasufumi |
| description | We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted. |
| doi_str_mv | 10.2169/internalmedicine.9745-22 |
| format | Article |
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A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.9745-22</identifier><identifier>PMID: 36261387</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Aged ; Ascites ; Ascites - etiology ; ATL ; Case Report ; chronic renal failure ; Cytology ; Effusion ; Hemodialysis ; Human T-lymphotropic virus 1 ; Humans ; Interleukin 2 ; Internal medicine ; L-Lactate dehydrogenase ; Leukemia-Lymphoma, Adult T-Cell - therapy ; Lymphadenopathy ; Lymphocytes T ; Lymphoma, Primary Effusion - diagnosis ; Male ; Peripheral blood ; Primary effusion lymphoma ; Receptors, Interleukin-2 ; Renal Dialysis - adverse effects</subject><ispartof>Internal Medicine, 2023/06/15, Vol.62(12), pp.1807-1811</ispartof><rights>2023 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c668t-bdcf4b4c472d17f6087d530ef07daad2e2b52e06591cd84c61f6c5e64c0bbb113</citedby><cites>FETCH-LOGICAL-c668t-bdcf4b4c472d17f6087d530ef07daad2e2b52e06591cd84c61f6c5e64c0bbb113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332963/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332963/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36261387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masaki, Miharu</creatorcontrib><creatorcontrib>Okushi, Yuki</creatorcontrib><creatorcontrib>Saito, Atsushi</creatorcontrib><creatorcontrib>Fukuda, Akihiro</creatorcontrib><creatorcontrib>Yamada, Sohsuke</creatorcontrib><creatorcontrib>Mizuta, Shuichi</creatorcontrib><creatorcontrib>Masaki, Yasufumi</creatorcontrib><title>Primary Effusion Lymphoma-like ATL Developing during Hemodialysis</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted.</description><subject>Adult</subject><subject>Aged</subject><subject>Ascites</subject><subject>Ascites - etiology</subject><subject>ATL</subject><subject>Case Report</subject><subject>chronic renal failure</subject><subject>Cytology</subject><subject>Effusion</subject><subject>Hemodialysis</subject><subject>Human T-lymphotropic virus 1</subject><subject>Humans</subject><subject>Interleukin 2</subject><subject>Internal medicine</subject><subject>L-Lactate dehydrogenase</subject><subject>Leukemia-Lymphoma, Adult T-Cell - therapy</subject><subject>Lymphadenopathy</subject><subject>Lymphocytes T</subject><subject>Lymphoma, Primary Effusion - diagnosis</subject><subject>Male</subject><subject>Peripheral blood</subject><subject>Primary effusion lymphoma</subject><subject>Receptors, Interleukin-2</subject><subject>Renal Dialysis - adverse effects</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkcFu2zAMhoVhxZp2e4XBwC67uJMoW7JPQ9B17YAA7aE9C7JEJ8psKZPsAnn72UsWbO2FBKGPv0j-hGSMXgET9RfnB4xedz1aZ5zHq1oWZQ7whiwYL-pcAi_fkgWtWZXDFM7JRUpbSnkla3hHzrkAwaZiQZYP0fU67rObth2TCz5b7fvdJvQ679xPzJaPq-wbPmMXds6vMzvGOd1hH6zT3T659J6ctbpL-OGYL8nT95vH67t8dX_743q5yo0Q1ZA31rRFU5hCgmWyFbSStuQUWyqt1hYQmhKQirJmxlaFEawVpkRRGNo0DWP8knw96O7GZtrboB-i7tTuML8K2qn_X7zbqHV4VoxyDrXgk8Lno0IMv0ZMg-pdMth12mMYkwIJogYqy2JCP71At2GcLz5RFZdQFuUfwepAmRhSitiepmFUzUapl0ap2SgFMLV-_HebU-NfZybg_gBs06DXeAJ0HJzp8LWyAMVgjscvTqTZ6KjQ898d9bKr</recordid><startdate>20230615</startdate><enddate>20230615</enddate><creator>Masaki, Miharu</creator><creator>Okushi, Yuki</creator><creator>Saito, Atsushi</creator><creator>Fukuda, Akihiro</creator><creator>Yamada, Sohsuke</creator><creator>Mizuta, Shuichi</creator><creator>Masaki, Yasufumi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230615</creationdate><title>Primary Effusion Lymphoma-like ATL Developing during Hemodialysis</title><author>Masaki, Miharu ; Okushi, Yuki ; Saito, Atsushi ; Fukuda, Akihiro ; Yamada, Sohsuke ; Mizuta, Shuichi ; Masaki, Yasufumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c668t-bdcf4b4c472d17f6087d530ef07daad2e2b52e06591cd84c61f6c5e64c0bbb113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Ascites</topic><topic>Ascites - etiology</topic><topic>ATL</topic><topic>Case Report</topic><topic>chronic renal failure</topic><topic>Cytology</topic><topic>Effusion</topic><topic>Hemodialysis</topic><topic>Human T-lymphotropic virus 1</topic><topic>Humans</topic><topic>Interleukin 2</topic><topic>Internal medicine</topic><topic>L-Lactate dehydrogenase</topic><topic>Leukemia-Lymphoma, Adult T-Cell - therapy</topic><topic>Lymphadenopathy</topic><topic>Lymphocytes T</topic><topic>Lymphoma, Primary Effusion - diagnosis</topic><topic>Male</topic><topic>Peripheral blood</topic><topic>Primary effusion lymphoma</topic><topic>Receptors, Interleukin-2</topic><topic>Renal Dialysis - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masaki, Miharu</creatorcontrib><creatorcontrib>Okushi, Yuki</creatorcontrib><creatorcontrib>Saito, Atsushi</creatorcontrib><creatorcontrib>Fukuda, Akihiro</creatorcontrib><creatorcontrib>Yamada, Sohsuke</creatorcontrib><creatorcontrib>Mizuta, Shuichi</creatorcontrib><creatorcontrib>Masaki, Yasufumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masaki, Miharu</au><au>Okushi, Yuki</au><au>Saito, Atsushi</au><au>Fukuda, Akihiro</au><au>Yamada, Sohsuke</au><au>Mizuta, Shuichi</au><au>Masaki, Yasufumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary Effusion Lymphoma-like ATL Developing during Hemodialysis</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-06-15</date><risdate>2023</risdate><volume>62</volume><issue>12</issue><spage>1807</spage><epage>1811</epage><pages>1807-1811</pages><artnum>9745-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>36261387</pmid><doi>10.2169/internalmedicine.9745-22</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Ascites Ascites - etiology ATL Case Report chronic renal failure Cytology Effusion Hemodialysis Human T-lymphotropic virus 1 Humans Interleukin 2 Internal medicine L-Lactate dehydrogenase Leukemia-Lymphoma, Adult T-Cell - therapy Lymphadenopathy Lymphocytes T Lymphoma, Primary Effusion - diagnosis Male Peripheral blood Primary effusion lymphoma Receptors, Interleukin-2 Renal Dialysis - adverse effects |
| title | Primary Effusion Lymphoma-like ATL Developing during Hemodialysis |
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