Translational relevance of SOS1 targeting for KRAS‐mutant colorectal cancer

It has been challenging to target mutant KRAS (mKRAS) in colorectal cancer (CRC) and other malignancies. Recent efforts have focused on developing inhibitors blocking molecules essential for KRAS activity. In this regard, SOS1 inhibition has arisen as an attractive approach for mKRAS CRC given its e...

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Veröffentlicht in:	Molecular carcinogenesis 2023-07, Vol.62 (7), p.1025-1037
Hauptverfasser:	Alem, Diego, Yang, Xinrui, Beato, Francisca, Sarcar, Bhaswati, Tassielli, Alexandra F., Dai, Ruifan, Hogenson, Tara L., Park, Margaret A., Jiang, Kun, Cai, Jianfeng, Yuan, Yu, Fernandez‐Zapico, Martin E., Tan, Aik Choon, Fleming, Jason B., Xie, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - genetics Homeostasis Humans Immunohistochemistry K-Ras protein KRAS Malignancy mRNA Mutants Mutation NF-κB protein Organoids Protein expression Proteins Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Raf protein Ras protein Sensitivity analysis Signal Transduction SOS1 SOS1 Protein - genetics SOS1 Protein - metabolism SOS2 Survival analysis therapeutics Translation
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