Improvement of muscle strength in familial hypokalaemic periodic paralysis with acetazolamide
A double blind cross-over study of eight patients with familial hypokalaemic periodic paralysis was made to assess the influence of acetazolamide on muscle strength. All patients had a reduced interictal muscle fibre conduction velocity. Five patients had no attacks at the time of the study. One pat...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1988-09, Vol.51 (9), p.1142-1145 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Links, T P Zwarts, M J Oosterhuis, H J |
| description | A double blind cross-over study of eight patients with familial hypokalaemic periodic paralysis was made to assess the influence of acetazolamide on muscle strength. All patients had a reduced interictal muscle fibre conduction velocity. Five patients had no attacks at the time of the study. One patient withdrew from the study because of an adverse reaction. The muscle strength of 11 muscle groups was measured with a hand-held dynamometer. The sum of force improved significantly in the seven patients (mean increase: 17%, p less than 0.05; 95% confidence interval: 7.2-26.8%). Endurance tests showed an improvement in the performance of 30 full kneebends. Surface EMG measurement showed no change in the muscle fibre conduction velocity or power spectra during treatment. The integrated EMG showed a (non significant) mean increase of 21%. |
| doi_str_mv | 10.1136/jnnp.51.9.1142 |
| format | Article |
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All patients had a reduced interictal muscle fibre conduction velocity. Five patients had no attacks at the time of the study. One patient withdrew from the study because of an adverse reaction. The muscle strength of 11 muscle groups was measured with a hand-held dynamometer. The sum of force improved significantly in the seven patients (mean increase: 17%, p less than 0.05; 95% confidence interval: 7.2-26.8%). Endurance tests showed an improvement in the performance of 30 full kneebends. Surface EMG measurement showed no change in the muscle fibre conduction velocity or power spectra during treatment. The integrated EMG showed a (non significant) mean increase of 21%.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.51.9.1142</identifier><identifier>PMID: 3066848</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Acetazolamide - therapeutic use ; Adult ; Clinical Trials as Topic ; Electromyography ; Female ; Humans ; Male ; Middle Aged ; Muscle Contraction - drug effects ; Muscles - drug effects ; Paralyses, Familial Periodic - drug therapy ; Random Allocation</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1988-09, Vol.51 (9), p.1142-1145</ispartof><rights>Copyright BMJ Publishing Group LTD Sep 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4002-43fe945769ec3943e75246f627caf319561b6531df396123ebdf532fc57ce1083</citedby><cites>FETCH-LOGICAL-b4002-43fe945769ec3943e75246f627caf319561b6531df396123ebdf532fc57ce1083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1033016/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1033016/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3066848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Links, T P</creatorcontrib><creatorcontrib>Zwarts, M J</creatorcontrib><creatorcontrib>Oosterhuis, H J</creatorcontrib><title>Improvement of muscle strength in familial hypokalaemic periodic paralysis with acetazolamide</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>A double blind cross-over study of eight patients with familial hypokalaemic periodic paralysis was made to assess the influence of acetazolamide on muscle strength. All patients had a reduced interictal muscle fibre conduction velocity. Five patients had no attacks at the time of the study. One patient withdrew from the study because of an adverse reaction. The muscle strength of 11 muscle groups was measured with a hand-held dynamometer. The sum of force improved significantly in the seven patients (mean increase: 17%, p less than 0.05; 95% confidence interval: 7.2-26.8%). Endurance tests showed an improvement in the performance of 30 full kneebends. Surface EMG measurement showed no change in the muscle fibre conduction velocity or power spectra during treatment. The integrated EMG showed a (non significant) mean increase of 21%.</description><subject>Acetazolamide - therapeutic use</subject><subject>Adult</subject><subject>Clinical Trials as Topic</subject><subject>Electromyography</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscles - drug effects</subject><subject>Paralyses, Familial Periodic - drug therapy</subject><subject>Random Allocation</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc2L1DAYxoMo67h69SYUBMFDx6Rvk7QXQQbdXVn0sspcJKSZNzuZbZuatKvjX2_KDIN6MZckPL_38yHkOaNLxkC82fX9sORsWadvWTwgC1aKKgeg64dkQWlR5EA5fUyexLij86nqM3IGVIiqrBbk21U3BH-PHfZj5m3WTdG0mMUxYH87bjPXZ1Z3rnW6zbb7wd_pVmPnTDZgcH4zP3TQ7T66mP1wKUAbHPUv36agDT4lj6xuIz473ufky4f3N6vL_PrzxdXq3XXelKnFvASLdcmlqNFAXQJKXpTCikIabYHVXLBGcGAbC7VgBWCzsRwKa7g0yGgF5-TtIe8wNR1uTBomNaWG4Dod9sprp_5WerdVt_5eMZo2xURK8OqYIPjvE8ZRdS4abFvdo5-ikpWQdcFn8OU_4M5PoU_DKSYlpH1XAIlaHigTfIwB7akVRtVsm5ptU5ypWs22pYAXfw5wwo8-JT0_6C6O-PMk63CnhATJ1aevKwUfb9aXa3qhVol_feCbbve_2r8BqPyx0g</recordid><startdate>19880901</startdate><enddate>19880901</enddate><creator>Links, T P</creator><creator>Zwarts, M J</creator><creator>Oosterhuis, H J</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19880901</creationdate><title>Improvement of muscle strength in familial hypokalaemic periodic paralysis with acetazolamide</title><author>Links, T P ; 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All patients had a reduced interictal muscle fibre conduction velocity. Five patients had no attacks at the time of the study. One patient withdrew from the study because of an adverse reaction. The muscle strength of 11 muscle groups was measured with a hand-held dynamometer. The sum of force improved significantly in the seven patients (mean increase: 17%, p less than 0.05; 95% confidence interval: 7.2-26.8%). Endurance tests showed an improvement in the performance of 30 full kneebends. Surface EMG measurement showed no change in the muscle fibre conduction velocity or power spectra during treatment. The integrated EMG showed a (non significant) mean increase of 21%.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>3066848</pmid><doi>10.1136/jnnp.51.9.1142</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-3050 |
| ispartof | Journal of neurology, neurosurgery and psychiatry, 1988-09, Vol.51 (9), p.1142-1145 |
| issn | 0022-3050 1468-330X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetazolamide - therapeutic use Adult Clinical Trials as Topic Electromyography Female Humans Male Middle Aged Muscle Contraction - drug effects Muscles - drug effects Paralyses, Familial Periodic - drug therapy Random Allocation |
| title | Improvement of muscle strength in familial hypokalaemic periodic paralysis with acetazolamide |
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