CpG Methylation Levels in HPA Axis Genes Predict Chronic Pain Outcomes Following Trauma Exposure

•Chronic musculoskeletal pain is common following traumatic stress exposure.•CpG DNA methylation levels in seven HPA axis stress genes predict chronic pain in trauma survivors.•CpG sites in POMC most strongly predict chronic pain and influence POMC mRNA levels.•Epigenetic regulation of stress system...

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Veröffentlicht in:	The journal of pain 2023-07, Vol.24 (7), p.1127-1141
Hauptverfasser:	Branham, Erica M., McLean, Samuel A., Deliwala, Ishani, Mauck, Matthew C., Zhao, Ying, McKibben, Lauren A., Lee, Aaron, Spencer, Alex B., Zannas, Anthony S., Lechner, Megan, Danza, Teresa, Velilla, Marc-Anthony, Hendry, Phyllis L., Pearson, Claire, Peak, David A., Jones, Jeffrey, Rathlev, Niels K., Linnstaedt, Sarah D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronic Pain - genetics Chronic Pain - metabolism DNA Methylation - genetics HPA axis Humans Hypothalamo-Hypophyseal System Longitudinal Studies Methylation pain Pituitary-Adrenal System POMC Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism trauma
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