Fructose: A New Variable to Consider in SIADH and the Hyponatremia Associated With Long-Distance Running?
Fructose has recently been proposed to stimulate vasopressin secretion in humans. Fructose-induced vasopressin secretion is not only postulated to result from ingestion of fructose-containing drinks but may also occur from endogenous fructose production via activation of the polyol pathway. This rai...
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| Veröffentlicht in: | American journal of kidney diseases 2023-07, Vol.82 (1), p.105-112 |
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| container_title | American journal of kidney diseases |
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| creator | Johnson, Richard J. Lee, S.M. Kurt Sánchez-Lozada, Laura G. Kanbay, Mehmet Bansal, Anip Tolan, Dean R. Bjornstad, Petter Lanaspa, Miguel A. Maesaka, John |
| description | Fructose has recently been proposed to stimulate vasopressin secretion in humans. Fructose-induced vasopressin secretion is not only postulated to result from ingestion of fructose-containing drinks but may also occur from endogenous fructose production via activation of the polyol pathway. This raises the question of whether fructose might be involved in some cases of vasopressin-induced hyponatremia, especially in situations where the cause is not fully known such as in the syndrome of inappropriate secretion of diuretic hormone (SIADH) and exercise-associated hyponatremia, which has been observed in marathon runners. Here we discuss the new science of fructose and vasopressin, and how it may play a role in some of these conditions, as well as in the complications associated with rapid treatment (such as the osmotic demyelination syndrome). Studies to test the role of fructose could provide new pathophysiologic insights as well as novel potential treatment strategies for these common conditions. |
| doi_str_mv | 10.1053/j.ajkd.2023.01.443 |
| format | Article |
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Here we discuss the new science of fructose and vasopressin, and how it may play a role in some of these conditions, as well as in the complications associated with rapid treatment (such as the osmotic demyelination syndrome). 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Kurt</creatorcontrib><creatorcontrib>Sánchez-Lozada, Laura G.</creatorcontrib><creatorcontrib>Kanbay, Mehmet</creatorcontrib><creatorcontrib>Bansal, Anip</creatorcontrib><creatorcontrib>Tolan, Dean R.</creatorcontrib><creatorcontrib>Bjornstad, Petter</creatorcontrib><creatorcontrib>Lanaspa, Miguel A.</creatorcontrib><creatorcontrib>Maesaka, John</creatorcontrib><title>Fructose: A New Variable to Consider in SIADH and the Hyponatremia Associated With Long-Distance Running?</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>Fructose has recently been proposed to stimulate vasopressin secretion in humans. Fructose-induced vasopressin secretion is not only postulated to result from ingestion of fructose-containing drinks but may also occur from endogenous fructose production via activation of the polyol pathway. 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Studies to test the role of fructose could provide new pathophysiologic insights as well as novel potential treatment strategies for these common conditions.</description><subject>Diuretics</subject><subject>Fructose</subject><subject>Humans</subject><subject>hyponatremia</subject><subject>Hyponatremia - complications</subject><subject>Hyponatremia - therapy</subject><subject>Inappropriate ADH Syndrome - complications</subject><subject>osmotic demyelination syndrome</subject><subject>polyol pathway</subject><subject>Running</subject><subject>SIADH</subject><subject>Vasopressins</subject><issn>0272-6386</issn><issn>1523-6838</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1qGzEUhUVpaZykL9BF0bKbmepnrJkJhWCcpA6YBvLXpZClO7acseRImpS8fWSchnbTlQT67tHlfAh9pqSkZMy_rUu1fjAlI4yXhJZVxd-hER0zXoiGN-_RiLCaFYI34gAdxrgmhLRciI_ogIu2InVFRshehEEnH-EET_BP-I3vVbBq0QNOHk-9i9ZAwNbhm8vJ2QwrZ3BaAZ49b71TKcDGKjyJ0WurEhj8y6YVnnu3LM5sTMppwNeDc9YtT4_Rh071ET69nkfo7uL8djor5lc_LqeTeaHzSqmohKhboYkej2lrapqvte6MEZXWxrSCqkovoF5oBh0o6DIOjVCV4U3bGAB-hE73udthsQGjwaWgerkNdqPCs_TKyn9fnF3JpX-SlHBOCGc54etrQvCPA8QkNzZq6HvlwA9RsrppWa6wERlle1QHH2OA7u0fSuROklzLnSS5kyQJlVlSHvry94ZvI3-sZOD7HoDc05OFIKO2kMs0NoBO0nj7v_wX2fGkog</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Johnson, Richard J.</creator><creator>Lee, S.M. 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Kurt ; Sánchez-Lozada, Laura G. ; Kanbay, Mehmet ; Bansal, Anip ; Tolan, Dean R. ; Bjornstad, Petter ; Lanaspa, Miguel A. ; Maesaka, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-466796c0c5519d716c07cfdd64ccdd961a4cbe7bc2efeaef667e86a4d3898dee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Diuretics</topic><topic>Fructose</topic><topic>Humans</topic><topic>hyponatremia</topic><topic>Hyponatremia - complications</topic><topic>Hyponatremia - therapy</topic><topic>Inappropriate ADH Syndrome - complications</topic><topic>osmotic demyelination syndrome</topic><topic>polyol pathway</topic><topic>Running</topic><topic>SIADH</topic><topic>Vasopressins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Richard J.</creatorcontrib><creatorcontrib>Lee, S.M. Kurt</creatorcontrib><creatorcontrib>Sánchez-Lozada, Laura G.</creatorcontrib><creatorcontrib>Kanbay, Mehmet</creatorcontrib><creatorcontrib>Bansal, Anip</creatorcontrib><creatorcontrib>Tolan, Dean R.</creatorcontrib><creatorcontrib>Bjornstad, Petter</creatorcontrib><creatorcontrib>Lanaspa, Miguel A.</creatorcontrib><creatorcontrib>Maesaka, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Richard J.</au><au>Lee, S.M. 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| identifier | ISSN: 0272-6386 |
| ispartof | American journal of kidney diseases, 2023-07, Vol.82 (1), p.105-112 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Diuretics Fructose Humans hyponatremia Hyponatremia - complications Hyponatremia - therapy Inappropriate ADH Syndrome - complications osmotic demyelination syndrome polyol pathway Running SIADH Vasopressins |
| title | Fructose: A New Variable to Consider in SIADH and the Hyponatremia Associated With Long-Distance Running? |
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