Porphyromonas gulae and PPAD antibodies are not related to citrullination in rheumatoid arthritis
Introduction Porphyromonas gulae have the enzyme PPAD, as P. gingivalis , which is responsible for citrullination related to the pathophysiology of rheumatoid arthritis and periodontitis; this implies the presence of two species of PPAD-producing bacteria in the mouth as well as the presence of citr...
Gespeichert in:
| Veröffentlicht in: | Clinical oral investigations 2023-07, Vol.27 (7), p.3509-3519 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3519 |
|---|---|
| container_issue | 7 |
| container_start_page | 3509 |
| container_title | Clinical oral investigations |
| container_volume | 27 |
| creator | Castellar-Mendoza, Camilo Castillo, Diana Marcela Chila-Moreno, Lorena Bautista-Molano, Wilson Romero-Sánchez, Consuelo |
| description | Introduction
Porphyromonas gulae
have the enzyme PPAD, as
P. gingivalis
, which is responsible for citrullination related to the pathophysiology of rheumatoid arthritis and periodontitis; this implies the presence of two species of PPAD-producing bacteria in the mouth as well as the presence of citrullinated proteins. There are no previous reports or studies investigating an association between
P. gulae
PPAD in rheumatoid arthritis (RA).
Objective
To assess the presence of
P. gulae
and anti-citrullinated peptide antibodies of
P. gulae
PAD in patients with RA and their possible relationship with clinical activity markers.
Subjects and methods
A total of 95 patients with RA and 95 controls were included. Erythrocyte sedimentation rate (ESR), C-reactive protein, anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) were measured. Activity index-28 (DAS28) and SCDAI. The periodontal diagnosis was established. Presence of
P. gulae
and
P. gingivalis
. An ELISA was used to determine antibodies against citrullinated peptides of
P. gulae
PAD.
Results
A
P. gulae
frequency of 15.8% was observed in the RA group and 9.5% in the control group. Higher levels of ACPA were found in the
P. gulae
-positive patients of the RA group, finding no significant difference, but if in patients positive for
P. gingivalis
with statistical significance (
p
= 0.0001). The frequency of anti-VDK-cit and anti-LPQ-cit9 antibodies to PPAD of
P. gulae
was higher in the RA group than in the control group without significant difference. No relationship was found with the clinical variables despite the presence of
P. gulae
and anti-citrullinated peptide antibodies of
P. gulae
PPAD in patients with RA
Conclusions
It was not possible to establish a connection with clinical variables in RA and
P. gulae
; as a result, the presence of
P. gingivalis
continues to contribute significantly to the increase in antibodies against citrullinated proteins/peptides from exogenous sources of citrullination in RA and periodontitis. |
| doi_str_mv | 10.1007/s00784-023-04964-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10329627</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2809002081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-7f8cd005cebfe6dc29dea4d7ec9171ac1242d9e2e3757bceb8b9c95bf433944f3</originalsourceid><addsrcrecordid>eNp9kU1PHSEUholpo9b2D7gwJN10My1fdxhWxljbmph4F3ZNGDhzL2YGrsBo_Pdir1rbhRs4yXnOCycPQoeUfKWEyG-5Hp1oCOMNEaoVzd0O2qeCtw2Xkr57Ve-hDzlfE0JFK_ku2uOSci4J2UdmGdNmfZ_iFIPJeDWPBrAJDi-XJ99rUXwfnYeMTQIcYsEJRlPA4RKx9SXN4-iDKT4G7ANOa5gnU6J3lS_r5IvPH9H7wYwZPj3dB-j3j7Or01_NxeXP89OTi8YK1pZGDp11hCws9AO0zjLlwAgnwSoqqbGUCeYUMOByIftKdb2yatEPgnMlxMAP0PE2dzP3EzgLoSQz6k3yk0n3Ohqv_-0Ev9areKsp4Uy1TNaEL08JKd7MkIuefLYwjiZAnLNmHVGEMNLRin7-D72Ocwp1v0pxseCdUKpSbEvZFHNOMLz8hhL9qFBvFeqqUP9RqO_q0NHrPV5Gnp1VgG-BXFthBenv22_EPgB7Tapm</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2834538499</pqid></control><display><type>article</type><title>Porphyromonas gulae and PPAD antibodies are not related to citrullination in rheumatoid arthritis</title><source>Springer Nature - Complete Springer Journals</source><creator>Castellar-Mendoza, Camilo ; Castillo, Diana Marcela ; Chila-Moreno, Lorena ; Bautista-Molano, Wilson ; Romero-Sánchez, Consuelo</creator><creatorcontrib>Castellar-Mendoza, Camilo ; Castillo, Diana Marcela ; Chila-Moreno, Lorena ; Bautista-Molano, Wilson ; Romero-Sánchez, Consuelo</creatorcontrib><description>Introduction
Porphyromonas gulae
have the enzyme PPAD, as
P. gingivalis
, which is responsible for citrullination related to the pathophysiology of rheumatoid arthritis and periodontitis; this implies the presence of two species of PPAD-producing bacteria in the mouth as well as the presence of citrullinated proteins. There are no previous reports or studies investigating an association between
P. gulae
PPAD in rheumatoid arthritis (RA).
Objective
To assess the presence of
P. gulae
and anti-citrullinated peptide antibodies of
P. gulae
PAD in patients with RA and their possible relationship with clinical activity markers.
Subjects and methods
A total of 95 patients with RA and 95 controls were included. Erythrocyte sedimentation rate (ESR), C-reactive protein, anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) were measured. Activity index-28 (DAS28) and SCDAI. The periodontal diagnosis was established. Presence of
P. gulae
and
P. gingivalis
. An ELISA was used to determine antibodies against citrullinated peptides of
P. gulae
PAD.
Results
A
P. gulae
frequency of 15.8% was observed in the RA group and 9.5% in the control group. Higher levels of ACPA were found in the
P. gulae
-positive patients of the RA group, finding no significant difference, but if in patients positive for
P. gingivalis
with statistical significance (
p
= 0.0001). The frequency of anti-VDK-cit and anti-LPQ-cit9 antibodies to PPAD of
P. gulae
was higher in the RA group than in the control group without significant difference. No relationship was found with the clinical variables despite the presence of
P. gulae
and anti-citrullinated peptide antibodies of
P. gulae
PPAD in patients with RA
Conclusions
It was not possible to establish a connection with clinical variables in RA and
P. gulae
; as a result, the presence of
P. gingivalis
continues to contribute significantly to the increase in antibodies against citrullinated proteins/peptides from exogenous sources of citrullination in RA and periodontitis.</description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-023-04964-w</identifier><identifier>PMID: 37133700</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antibodies ; C-reactive protein ; Citrulline ; Dental health ; Dentistry ; Diagnostic tests ; Enzyme-linked immunosorbent assay ; Erythrocyte sedimentation rate ; Gram-negative bacteria ; Gum disease ; Medicine ; Oral hygiene ; Pathophysiology ; Peptides ; Periodontics ; Periodontitis ; Porphyromonas ; Rheumatoid arthritis ; Rheumatoid factor</subject><ispartof>Clinical oral investigations, 2023-07, Vol.27 (7), p.3509-3519</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-7f8cd005cebfe6dc29dea4d7ec9171ac1242d9e2e3757bceb8b9c95bf433944f3</cites><orcidid>0000-0002-1846-7448 ; 0000-0003-0684-9542 ; 0000-0002-1911-2892 ; 0000-0003-2811-0626 ; 0000-0002-6973-7639</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-023-04964-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-023-04964-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37133700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castellar-Mendoza, Camilo</creatorcontrib><creatorcontrib>Castillo, Diana Marcela</creatorcontrib><creatorcontrib>Chila-Moreno, Lorena</creatorcontrib><creatorcontrib>Bautista-Molano, Wilson</creatorcontrib><creatorcontrib>Romero-Sánchez, Consuelo</creatorcontrib><title>Porphyromonas gulae and PPAD antibodies are not related to citrullination in rheumatoid arthritis</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Introduction
Porphyromonas gulae
have the enzyme PPAD, as
P. gingivalis
, which is responsible for citrullination related to the pathophysiology of rheumatoid arthritis and periodontitis; this implies the presence of two species of PPAD-producing bacteria in the mouth as well as the presence of citrullinated proteins. There are no previous reports or studies investigating an association between
P. gulae
PPAD in rheumatoid arthritis (RA).
Objective
To assess the presence of
P. gulae
and anti-citrullinated peptide antibodies of
P. gulae
PAD in patients with RA and their possible relationship with clinical activity markers.
Subjects and methods
A total of 95 patients with RA and 95 controls were included. Erythrocyte sedimentation rate (ESR), C-reactive protein, anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) were measured. Activity index-28 (DAS28) and SCDAI. The periodontal diagnosis was established. Presence of
P. gulae
and
P. gingivalis
. An ELISA was used to determine antibodies against citrullinated peptides of
P. gulae
PAD.
Results
A
P. gulae
frequency of 15.8% was observed in the RA group and 9.5% in the control group. Higher levels of ACPA were found in the
P. gulae
-positive patients of the RA group, finding no significant difference, but if in patients positive for
P. gingivalis
with statistical significance (
p
= 0.0001). The frequency of anti-VDK-cit and anti-LPQ-cit9 antibodies to PPAD of
P. gulae
was higher in the RA group than in the control group without significant difference. No relationship was found with the clinical variables despite the presence of
P. gulae
and anti-citrullinated peptide antibodies of
P. gulae
PPAD in patients with RA
Conclusions
It was not possible to establish a connection with clinical variables in RA and
P. gulae
; as a result, the presence of
P. gingivalis
continues to contribute significantly to the increase in antibodies against citrullinated proteins/peptides from exogenous sources of citrullination in RA and periodontitis.</description><subject>Antibodies</subject><subject>C-reactive protein</subject><subject>Citrulline</subject><subject>Dental health</subject><subject>Dentistry</subject><subject>Diagnostic tests</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Erythrocyte sedimentation rate</subject><subject>Gram-negative bacteria</subject><subject>Gum disease</subject><subject>Medicine</subject><subject>Oral hygiene</subject><subject>Pathophysiology</subject><subject>Peptides</subject><subject>Periodontics</subject><subject>Periodontitis</subject><subject>Porphyromonas</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><issn>1436-3771</issn><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1PHSEUholpo9b2D7gwJN10My1fdxhWxljbmph4F3ZNGDhzL2YGrsBo_Pdir1rbhRs4yXnOCycPQoeUfKWEyG-5Hp1oCOMNEaoVzd0O2qeCtw2Xkr57Ve-hDzlfE0JFK_ku2uOSci4J2UdmGdNmfZ_iFIPJeDWPBrAJDi-XJ99rUXwfnYeMTQIcYsEJRlPA4RKx9SXN4-iDKT4G7ANOa5gnU6J3lS_r5IvPH9H7wYwZPj3dB-j3j7Or01_NxeXP89OTi8YK1pZGDp11hCws9AO0zjLlwAgnwSoqqbGUCeYUMOByIftKdb2yatEPgnMlxMAP0PE2dzP3EzgLoSQz6k3yk0n3Ohqv_-0Ev9areKsp4Uy1TNaEL08JKd7MkIuefLYwjiZAnLNmHVGEMNLRin7-D72Ocwp1v0pxseCdUKpSbEvZFHNOMLz8hhL9qFBvFeqqUP9RqO_q0NHrPV5Gnp1VgG-BXFthBenv22_EPgB7Tapm</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Castellar-Mendoza, Camilo</creator><creator>Castillo, Diana Marcela</creator><creator>Chila-Moreno, Lorena</creator><creator>Bautista-Molano, Wilson</creator><creator>Romero-Sánchez, Consuelo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1846-7448</orcidid><orcidid>https://orcid.org/0000-0003-0684-9542</orcidid><orcidid>https://orcid.org/0000-0002-1911-2892</orcidid><orcidid>https://orcid.org/0000-0003-2811-0626</orcidid><orcidid>https://orcid.org/0000-0002-6973-7639</orcidid></search><sort><creationdate>20230701</creationdate><title>Porphyromonas gulae and PPAD antibodies are not related to citrullination in rheumatoid arthritis</title><author>Castellar-Mendoza, Camilo ; Castillo, Diana Marcela ; Chila-Moreno, Lorena ; Bautista-Molano, Wilson ; Romero-Sánchez, Consuelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-7f8cd005cebfe6dc29dea4d7ec9171ac1242d9e2e3757bceb8b9c95bf433944f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibodies</topic><topic>C-reactive protein</topic><topic>Citrulline</topic><topic>Dental health</topic><topic>Dentistry</topic><topic>Diagnostic tests</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Erythrocyte sedimentation rate</topic><topic>Gram-negative bacteria</topic><topic>Gum disease</topic><topic>Medicine</topic><topic>Oral hygiene</topic><topic>Pathophysiology</topic><topic>Peptides</topic><topic>Periodontics</topic><topic>Periodontitis</topic><topic>Porphyromonas</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castellar-Mendoza, Camilo</creatorcontrib><creatorcontrib>Castillo, Diana Marcela</creatorcontrib><creatorcontrib>Chila-Moreno, Lorena</creatorcontrib><creatorcontrib>Bautista-Molano, Wilson</creatorcontrib><creatorcontrib>Romero-Sánchez, Consuelo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castellar-Mendoza, Camilo</au><au>Castillo, Diana Marcela</au><au>Chila-Moreno, Lorena</au><au>Bautista-Molano, Wilson</au><au>Romero-Sánchez, Consuelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porphyromonas gulae and PPAD antibodies are not related to citrullination in rheumatoid arthritis</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>27</volume><issue>7</issue><spage>3509</spage><epage>3519</epage><pages>3509-3519</pages><issn>1436-3771</issn><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Introduction
Porphyromonas gulae
have the enzyme PPAD, as
P. gingivalis
, which is responsible for citrullination related to the pathophysiology of rheumatoid arthritis and periodontitis; this implies the presence of two species of PPAD-producing bacteria in the mouth as well as the presence of citrullinated proteins. There are no previous reports or studies investigating an association between
P. gulae
PPAD in rheumatoid arthritis (RA).
Objective
To assess the presence of
P. gulae
and anti-citrullinated peptide antibodies of
P. gulae
PAD in patients with RA and their possible relationship with clinical activity markers.
Subjects and methods
A total of 95 patients with RA and 95 controls were included. Erythrocyte sedimentation rate (ESR), C-reactive protein, anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) were measured. Activity index-28 (DAS28) and SCDAI. The periodontal diagnosis was established. Presence of
P. gulae
and
P. gingivalis
. An ELISA was used to determine antibodies against citrullinated peptides of
P. gulae
PAD.
Results
A
P. gulae
frequency of 15.8% was observed in the RA group and 9.5% in the control group. Higher levels of ACPA were found in the
P. gulae
-positive patients of the RA group, finding no significant difference, but if in patients positive for
P. gingivalis
with statistical significance (
p
= 0.0001). The frequency of anti-VDK-cit and anti-LPQ-cit9 antibodies to PPAD of
P. gulae
was higher in the RA group than in the control group without significant difference. No relationship was found with the clinical variables despite the presence of
P. gulae
and anti-citrullinated peptide antibodies of
P. gulae
PPAD in patients with RA
Conclusions
It was not possible to establish a connection with clinical variables in RA and
P. gulae
; as a result, the presence of
P. gingivalis
continues to contribute significantly to the increase in antibodies against citrullinated proteins/peptides from exogenous sources of citrullination in RA and periodontitis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37133700</pmid><doi>10.1007/s00784-023-04964-w</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1846-7448</orcidid><orcidid>https://orcid.org/0000-0003-0684-9542</orcidid><orcidid>https://orcid.org/0000-0002-1911-2892</orcidid><orcidid>https://orcid.org/0000-0003-2811-0626</orcidid><orcidid>https://orcid.org/0000-0002-6973-7639</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-3771 |
| ispartof | Clinical oral investigations, 2023-07, Vol.27 (7), p.3509-3519 |
| issn | 1436-3771 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10329627 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Antibodies C-reactive protein Citrulline Dental health Dentistry Diagnostic tests Enzyme-linked immunosorbent assay Erythrocyte sedimentation rate Gram-negative bacteria Gum disease Medicine Oral hygiene Pathophysiology Peptides Periodontics Periodontitis Porphyromonas Rheumatoid arthritis Rheumatoid factor |
| title | Porphyromonas gulae and PPAD antibodies are not related to citrullination in rheumatoid arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T16%3A56%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Porphyromonas%20gulae%20and%20PPAD%20antibodies%20are%20not%20related%20to%20citrullination%20in%20rheumatoid%20arthritis&rft.jtitle=Clinical%20oral%20investigations&rft.au=Castellar-Mendoza,%20Camilo&rft.date=2023-07-01&rft.volume=27&rft.issue=7&rft.spage=3509&rft.epage=3519&rft.pages=3509-3519&rft.issn=1436-3771&rft.eissn=1436-3771&rft_id=info:doi/10.1007/s00784-023-04964-w&rft_dat=%3Cproquest_pubme%3E2809002081%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2834538499&rft_id=info:pmid/37133700&rfr_iscdi=true |