The role of CD8+ T-cell clones in immune thrombocytopenia

•Patients with chronic ITP had clonal expansions of disease-associated TEMRA CD8+ T cells.•CD8+ T cells bind to platelets and cause their activation and apoptosis, defining an antibody-independent mechanism of platelet destruction. [Display omitted] Immune thrombocytopenia (ITP) is traditionally con...

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Veröffentlicht in:	Blood 2023-05, Vol.141 (20), p.2417-2429
Hauptverfasser:	Malik, Amna, Sayed, Anwar A., Han, Panpan, Tan, Michelle M. H., Watt, Eleanor, Constantinescu-Bercu, Adela, Cocker, Alexander T. H., Khoder, Ahmad, Saputil, Rocel C., Thorley, Emma, Teklemichael, Ariam, Ding, Yunchuan, Hart, Alice C. J., Zhang, Haiyu, Mitchell, Wayne A., Imami, Nesrina, Crawley, James T. B., Salles-Crawley, Isabelle I., Bussel, James B., Zehnder, James L., Adams, Stuart, Zhang, Bing M., Cooper, Nichola
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult CD8-Positive T-Lymphocytes Clone Cells - pathology Humans Interferon-gamma Plenary Paper Purpura, Thrombocytopenic, Idiopathic Receptors, Antigen, T-Cell
Online-Zugang:	Volltext
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