Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling

Biophysical cues of rigid tumor matrix play a critical role in cancer cell malignancy. We report that stiffly confined cancer cells exhibit robust growth of spheroids in the stiff hydrogel that exerts substantial confining stress on the cells. The stressed condition activated Hsp (heat shock protein...

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Veröffentlicht in:	Science advances 2023-07, Vol.9 (27), p.eadg9593-eadg9593
Hauptverfasser:	Wong, Siu Hong Dexter, Yin, Bohan, Li, Zhuo, Yuan, Weihao, Zhang, Qin, Xie, Xian, Tan, Youhua, Wong, Nathalie, Zhang, Kunyu, Bian, Liming
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine and Life Sciences Biophysics Cancer SciAdv r-articles
Online-Zugang:	Volltext
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