mTORC1 activity negatively regulates human hair follicle growth and pigmentation

Dysregulation of the activity of the mechanistic target of rapamycin complex 1 (mTORC1) is commonly linked to aging, cancer, and genetic disorders such as tuberous sclerosis (TS), a rare neurodevelopmental multisystemic disease characterized by benign tumors, seizures, and intellectual disability. A...

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Veröffentlicht in:	EMBO reports 2023-07, Vol.24 (7), p.e56574-n/a
Hauptverfasser:	Suzuki, Takahiro, Chéret, Jérémy, Scala, Fernanda Dinelli, Akhundlu, Aysun, Gherardini, Jennifer, Demetrius, Dana‐Lee, O'Sullivan, James D B, Kuka Epstein, Gorana, Bauman, Alan J, Demetriades, Constantinos, Paus, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha‐MSH/MC1R Disorders EMBO24 EMBO37 EMBO38 Follicles Genetic disorders Hair Hair loss Intellectual disabilities Life Sciences Melanin melanocyte Melanocytes Molecular modelling mTORC1 Neurodevelopmental disorders Pigmentation Rapamycin Scalp Seizures Survival TOR protein Tuberous sclerosis Tuberous Sclerosis Complex 2
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