eIF4EHP promotes Ldh mRNA translation in and fruit fly adaptation to hypoxia

Hypoxia induces profound modifications in the gene expression program of eukaryotic cells due to lowered ATP supply resulting from the blockade of oxidative phosphorylation. One significant consequence of oxygen deprivation is the massive repression of protein synthesis, leaving a limited set of mRN...

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Veröffentlicht in:	EMBO reports 2023-07, Vol.24 (7), p.e56460-n/a
Hauptverfasser:	Liang, Manfei, Hody, Clara, Yammine, Vanessa, Soin, Romuald, Sun, Yuqiu, Lin, Xing, Tian, Xiaoying, Meurs, Romane, Perdrau, Camille, Delacourt, Nadège, Oumalis, Marina, Andris, Fabienne, Conrard, Louise, Kruys, Véronique, Gueydan, Cyril
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 3′ untranslated region Adaptation Animals Cap-binding protein Dehydrogenase Dehydrogenases development Drosophila Drosophila - genetics Drosophila - metabolism Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - metabolism EMBO32 Fruit flies Gene expression Hypoxia Hypoxia - genetics Initiation factors Insects L-Lactate dehydrogenase L-Lactate Dehydrogenase - genetics L-Lactate Dehydrogenase - metabolism Lactate dehydrogenase Lactic acid Life Sciences Oxidative phosphorylation Oxygen Oxygen - metabolism Phosphorylation Polyribosomes Protein Biosynthesis Protein synthesis Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Transcription translation
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