Quantitative objective assessment of peripheral nociceptive C fibre function
A technique is described for the quantitative assessment of peripheral nociceptive C fibre function by measurement of the axon reflex flare. Acetylcholine, introduced by electrophoresis, is used to stimulate a ring of nociceptive C fibre endings at the centre of which the increase in blood flow is m...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1988-01, Vol.51 (1), p.28-34 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
| container_volume | 51 |
| creator | Parkhouse, N Le Quesne, P M |
| description | A technique is described for the quantitative assessment of peripheral nociceptive C fibre function by measurement of the axon reflex flare. Acetylcholine, introduced by electrophoresis, is used to stimulate a ring of nociceptive C fibre endings at the centre of which the increase in blood flow is measured with a laser Doppler flowmeter. This flare (neurogenic vasodilatation) has been compared with mechanically or chemically stimulated non-neurogenic cutaneous vasodilation. The flare is abolished by local anaesthetic and is absent in denervated skin. The flare has been measured on the sole of the foot of 96 healthy subjects; its size decreases with age in males, but not in females. |
| doi_str_mv | 10.1136/jnnp.51.1.28 |
| format | Article |
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Acetylcholine, introduced by electrophoresis, is used to stimulate a ring of nociceptive C fibre endings at the centre of which the increase in blood flow is measured with a laser Doppler flowmeter. This flare (neurogenic vasodilatation) has been compared with mechanically or chemically stimulated non-neurogenic cutaneous vasodilation. The flare is abolished by local anaesthetic and is absent in denervated skin. The flare has been measured on the sole of the foot of 96 healthy subjects; its size decreases with age in males, but not in females.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.51.1.28</identifier><identifier>PMID: 3351528</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Acetylcholine ; Adult ; Aged ; Axons - physiology ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Middle Aged ; Nerve Fibers - physiology ; Nociceptors - physiology ; Peripheral Nerves - physiology ; Reference Values ; Reflex - physiology ; Skin - innervation ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1988-01, Vol.51 (1), p.28-34</ispartof><rights>1988 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jan 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b535t-4de6982662252076b0ca7ec53ab2998f584c39f2358bd79677588518e2bd3c333</citedby><cites>FETCH-LOGICAL-b535t-4de6982662252076b0ca7ec53ab2998f584c39f2358bd79677588518e2bd3c333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1032710/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1032710/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7743175$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3351528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parkhouse, N</creatorcontrib><creatorcontrib>Le Quesne, P M</creatorcontrib><title>Quantitative objective assessment of peripheral nociceptive C fibre function</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>A technique is described for the quantitative assessment of peripheral nociceptive C fibre function by measurement of the axon reflex flare. Acetylcholine, introduced by electrophoresis, is used to stimulate a ring of nociceptive C fibre endings at the centre of which the increase in blood flow is measured with a laser Doppler flowmeter. This flare (neurogenic vasodilatation) has been compared with mechanically or chemically stimulated non-neurogenic cutaneous vasodilation. The flare is abolished by local anaesthetic and is absent in denervated skin. The flare has been measured on the sole of the foot of 96 healthy subjects; its size decreases with age in males, but not in females.</description><subject>Acetylcholine</subject><subject>Adult</subject><subject>Aged</subject><subject>Axons - physiology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Fibers - physiology</subject><subject>Nociceptors - physiology</subject><subject>Peripheral Nerves - physiology</subject><subject>Reference Values</subject><subject>Reflex - physiology</subject><subject>Skin - innervation</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUuv1CAYhonRHOeM7tyaNNHoxo7AVwrdmJjJOV4yajTedgQY6qG2UKE90X8vc8lEXcgCSN6HLw95EbpH8IoQqJ923o8rRlZkRcUNtCBVLUoA_PUmWmBMaQmY4dvoPKUO75ZoztAZACOMigXavJ-Vn9ykJndti6A7a_Y3lZJNabB-KkJbjDa68cpG1Rc-GGfsuIfWRet0tEU7-_wq-DvoVqv6ZO8ezyX6dHnxcf2y3Lx78Wr9fFNqBmwqq62tG0HrmlJGMa81Nopbw0Bp2jSiZaIy0LQUmNBb3tScMyEYEZbqLRgAWKJnh7njrAe7Ndkyq8kxukHFXzIoJ_9OvLuS38K1JBgoz9sSPToOiOHHbNMkB5eM7XvlbZiT5IJUjAHP4IN_wC7M0efPScI5YIIrKjL15ECZGFKKtj2pECx3HcldR5IRSeQev_-n_gk-lpLzh8dcJaP6NipvXDphnFdAOMtYecBcmuzPU6zid1lz4Ey-_byWb_gHgb9cvpYk848PvB66_wv-BgnMtiI</recordid><startdate>198801</startdate><enddate>198801</enddate><creator>Parkhouse, N</creator><creator>Le Quesne, P M</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198801</creationdate><title>Quantitative objective assessment of peripheral nociceptive C fibre function</title><author>Parkhouse, N ; Le Quesne, P M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b535t-4de6982662252076b0ca7ec53ab2998f584c39f2358bd79677588518e2bd3c333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acetylcholine</topic><topic>Adult</topic><topic>Aged</topic><topic>Axons - physiology</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Fibers - physiology</topic><topic>Nociceptors - physiology</topic><topic>Peripheral Nerves - physiology</topic><topic>Reference Values</topic><topic>Reflex - physiology</topic><topic>Skin - innervation</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parkhouse, N</creatorcontrib><creatorcontrib>Le Quesne, P M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parkhouse, N</au><au>Le Quesne, P M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative objective assessment of peripheral nociceptive C fibre function</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1988-01</date><risdate>1988</risdate><volume>51</volume><issue>1</issue><spage>28</spage><epage>34</epage><pages>28-34</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>A technique is described for the quantitative assessment of peripheral nociceptive C fibre function by measurement of the axon reflex flare. Acetylcholine, introduced by electrophoresis, is used to stimulate a ring of nociceptive C fibre endings at the centre of which the increase in blood flow is measured with a laser Doppler flowmeter. This flare (neurogenic vasodilatation) has been compared with mechanically or chemically stimulated non-neurogenic cutaneous vasodilation. The flare is abolished by local anaesthetic and is absent in denervated skin. The flare has been measured on the sole of the foot of 96 healthy subjects; its size decreases with age in males, but not in females.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>3351528</pmid><doi>10.1136/jnnp.51.1.28</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 1988-01, Vol.51 (1), p.28-34 |
| issn | 0022-3050 1468-330X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetylcholine Adult Aged Axons - physiology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Humans Male Middle Aged Nerve Fibers - physiology Nociceptors - physiology Peripheral Nerves - physiology Reference Values Reflex - physiology Skin - innervation Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Quantitative objective assessment of peripheral nociceptive C fibre function |
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