Clinical and biochemical effects of gamma-vinyl Gaba in tardive dyskinesia
Clinical and biochemical effects of Gamma-vinyl-Gaba (GVG) have been evaluated in a blind video-controlled study in 10 psychiatric patients (mean age 71 yr) with tardive dyskinesia. CSF free and total Gaba and homocarnosine concentrations increased from three to five fold with GVG treatment. Despite...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1987-12, Vol.50 (12), p.1674-1678 |
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| container_end_page | 1678 |
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| container_issue | 12 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Gaio, J M Pollak, P Hommel, M Perret, J |
| description | Clinical and biochemical effects of Gamma-vinyl-Gaba (GVG) have been evaluated in a blind video-controlled study in 10 psychiatric patients (mean age 71 yr) with tardive dyskinesia. CSF free and total Gaba and homocarnosine concentrations increased from three to five fold with GVG treatment. Despite the GVG-induced biological effects on Gaba metabolism, GVG did not consistently improve tardive dyskinesia. Psychomotor side-effects occurred in older patients, who only tolerated GVG dosages of 2-4 g/day. |
| doi_str_mv | 10.1136/jnnp.50.12.1674 |
| format | Article |
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CSF free and total Gaba and homocarnosine concentrations increased from three to five fold with GVG treatment. Despite the GVG-induced biological effects on Gaba metabolism, GVG did not consistently improve tardive dyskinesia. Psychomotor side-effects occurred in older patients, who only tolerated GVG dosages of 2-4 g/day.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.50.12.1674</identifier><identifier>PMID: 3437301</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; Aminocaproates - adverse effects ; Aminocaproates - therapeutic use ; Biological and medical sciences ; Carnosine - analogs & derivatives ; Carnosine - cerebrospinal fluid ; Dyskinesia, Drug-Induced - cerebrospinal fluid ; Dyskinesia, Drug-Induced - drug therapy ; Dyskinesia, Drug-Induced - physiopathology ; gamma-Aminobutyric Acid - cerebrospinal fluid ; Humans ; Medical sciences ; Mental Disorders - cerebrospinal fluid ; Mental Disorders - physiopathology ; Miscellaneous ; Neuropharmacology ; Pharmacology. 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CSF free and total Gaba and homocarnosine concentrations increased from three to five fold with GVG treatment. Despite the GVG-induced biological effects on Gaba metabolism, GVG did not consistently improve tardive dyskinesia. Psychomotor side-effects occurred in older patients, who only tolerated GVG dosages of 2-4 g/day.</description><subject>Aged</subject><subject>Aminocaproates - adverse effects</subject><subject>Aminocaproates - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carnosine - analogs & derivatives</subject><subject>Carnosine - cerebrospinal fluid</subject><subject>Dyskinesia, Drug-Induced - cerebrospinal fluid</subject><subject>Dyskinesia, Drug-Induced - drug therapy</subject><subject>Dyskinesia, Drug-Induced - physiopathology</subject><subject>gamma-Aminobutyric Acid - cerebrospinal fluid</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mental Disorders - cerebrospinal fluid</subject><subject>Mental Disorders - physiopathology</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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CSF free and total Gaba and homocarnosine concentrations increased from three to five fold with GVG treatment. Despite the GVG-induced biological effects on Gaba metabolism, GVG did not consistently improve tardive dyskinesia. Psychomotor side-effects occurred in older patients, who only tolerated GVG dosages of 2-4 g/day.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>3437301</pmid><doi>10.1136/jnnp.50.12.1674</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0022-3050 1468-330X |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Aminocaproates - adverse effects Aminocaproates - therapeutic use Biological and medical sciences Carnosine - analogs & derivatives Carnosine - cerebrospinal fluid Dyskinesia, Drug-Induced - cerebrospinal fluid Dyskinesia, Drug-Induced - drug therapy Dyskinesia, Drug-Induced - physiopathology gamma-Aminobutyric Acid - cerebrospinal fluid Humans Medical sciences Mental Disorders - cerebrospinal fluid Mental Disorders - physiopathology Miscellaneous Neuropharmacology Pharmacology. Drug treatments Vigabatrin |
| title | Clinical and biochemical effects of gamma-vinyl Gaba in tardive dyskinesia |
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