Deep integrative models for large-scale human genomics

Abstract Polygenic risk scores (PRSs) are expected to play a critical role in precision medicine. Currently, PRS predictors are generally based on linear models using summary statistics, and more recently individual-level data. However, these predictors mainly capture additive relationships and are...

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Veröffentlicht in:	Nucleic acids research 2023-07, Vol.51 (12), p.e67-e67
Hauptverfasser:	Sigurdsson, Arnór I, Louloudis, Ioannis, Banasik, Karina, Westergaard, David, Winther, Ole, Lund, Ole, Ostrowski, Sisse Rye, Erikstrup, Christian, Pedersen, Ole Birger Vesterager, Nyegaard, Mette, Brunak, Søren, Vilhjálmsson, Bjarni J, Rasmussen, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Predisposition to Disease Genome, Human Genome-Wide Association Study Genomics - methods Genotype Humans Methods Online Models, Genetic Multifactorial Inheritance Polymorphism, Single Nucleotide Risk Factors
Online-Zugang:	Volltext
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