Rigidity and dorsiflexion of the neck in progressive supranuclear palsy and the interstitial nucleus of Cajal
Rigidity and dorsiflexion of the neck are typical signs in progressive supranuclear palsy, but the responsible areas in the brain are unknown. To examine whether bilateral lesions of the interstitial nucleus of Cajal (INC) in the midbrain tegmentum contribute to the signs of patients with progressiv...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1987-09, Vol.50 (9), p.1197-1203 |
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| creator | Fukushima-Kudo, J Fukushima, K Tashiro, K |
| description | Rigidity and dorsiflexion of the neck are typical signs in progressive supranuclear palsy, but the responsible areas in the brain are unknown. To examine whether bilateral lesions of the interstitial nucleus of Cajal (INC) in the midbrain tegmentum contribute to the signs of patients with progressive supranuclear palsy, we have made bilateral INC lesions in cats and tried to correlate these studies with clinical and pathological data, including our case of progressive supranuclear palsy. Bilateral INC lesioned cats showed dorsiflexion of the neck and impairment of vertical eye movement, similar to progressive supranuclear palsy patients. Analysis of the previous clinical-pathological studies and our case have shown that dorsiflexion of the neck in progressive supranuclear palsy patients was correlated more with INC lesions than lesions of the basal ganglia. |
| doi_str_mv | 10.1136/jnnp.50.9.1197 |
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To examine whether bilateral lesions of the interstitial nucleus of Cajal (INC) in the midbrain tegmentum contribute to the signs of patients with progressive supranuclear palsy, we have made bilateral INC lesions in cats and tried to correlate these studies with clinical and pathological data, including our case of progressive supranuclear palsy. Bilateral INC lesioned cats showed dorsiflexion of the neck and impairment of vertical eye movement, similar to progressive supranuclear palsy patients. Analysis of the previous clinical-pathological studies and our case have shown that dorsiflexion of the neck in progressive supranuclear palsy patients was correlated more with INC lesions than lesions of the basal ganglia.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.50.9.1197</identifier><identifier>PMID: 3668569</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; Animals ; Basal Ganglia - physiopathology ; Biological and medical sciences ; Brain Mapping ; Cats ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dominance, Cerebral - physiology ; Eye Movements ; Humans ; Male ; Medical sciences ; Muscle Rigidity - physiopathology ; Muscles - innervation ; Neck Muscles - innervation ; Neurology ; Supranuclear Palsy, Progressive - physiopathology ; Tegmentum Mesencephali - physiopathology ; Tomography, X-Ray Computed</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1987-09, Vol.50 (9), p.1197-1203</ispartof><rights>1988 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Sep 1987</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b609t-b9f1532ded0b6e914df0e1d134ba1dc72e25b425e97ee282498966f0faec51493</citedby><cites>FETCH-LOGICAL-b609t-b9f1532ded0b6e914df0e1d134ba1dc72e25b425e97ee282498966f0faec51493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1032355/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1032355/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7426901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3668569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukushima-Kudo, J</creatorcontrib><creatorcontrib>Fukushima, K</creatorcontrib><creatorcontrib>Tashiro, K</creatorcontrib><title>Rigidity and dorsiflexion of the neck in progressive supranuclear palsy and the interstitial nucleus of Cajal</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Rigidity and dorsiflexion of the neck are typical signs in progressive supranuclear palsy, but the responsible areas in the brain are unknown. To examine whether bilateral lesions of the interstitial nucleus of Cajal (INC) in the midbrain tegmentum contribute to the signs of patients with progressive supranuclear palsy, we have made bilateral INC lesions in cats and tried to correlate these studies with clinical and pathological data, including our case of progressive supranuclear palsy. Bilateral INC lesioned cats showed dorsiflexion of the neck and impairment of vertical eye movement, similar to progressive supranuclear palsy patients. 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Prion diseases</subject><subject>Dominance, Cerebral - physiology</subject><subject>Eye Movements</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Rigidity - physiopathology</subject><subject>Muscles - innervation</subject><subject>Neck Muscles - innervation</subject><subject>Neurology</subject><subject>Supranuclear Palsy, Progressive - physiopathology</subject><subject>Tegmentum Mesencephali - physiopathology</subject><subject>Tomography, X-Ray Computed</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcuL1EAQxhtR1tnVqzchoAgeMvY76Yugwz6UVcEX3ppOUpnt2aQ7difL7n9vxwyDerEuTfH96qOqP4SeELwmhMlXO-eGtcBrlVpV3EMrwmWZM4Z_3EcrjCnNGRb4ITqOcYfnKtUROmJSlkKqFeo_261t7HiXGddkjQ_Rth3cWu8y32bjFWQO6uvMumwIfhsgRnsDWZyGYNxUd2BCNpguLuMzbt0IIY52tKbLfiNTnK02Zme6R-hBm2h4vH9P0Lez06-bi_zy0_m7zZvLvJJYjXmlWiIYbaDBlQRFeNNiIA1hvDKkqQsKVFScClAFAC0pV6WSssWtgVoQrtgJer34DlPVQ1ODG4Pp9BBsb8Kd9sbqvxVnr_TW32iCGWVCJIMXe4Pgf04QR93bWEPXGQd-irokuOCE8gQ--wfc-Sm4dJwmRcHSd2MqE7VeqDr4GAO0h1UI1nOMeo5RC6yVnmNMA0__POCA73NL-vO9bmJtujalUdt4wApOpcIkYfmC2TjC7UE24VrLghVCf_y-0fz9h_O3xZcLfZb4lwtf9bv_rfgLtx3E2Q</recordid><startdate>19870901</startdate><enddate>19870901</enddate><creator>Fukushima-Kudo, J</creator><creator>Fukushima, K</creator><creator>Tashiro, K</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19870901</creationdate><title>Rigidity and dorsiflexion of the neck in progressive supranuclear palsy and the interstitial nucleus of Cajal</title><author>Fukushima-Kudo, J ; Fukushima, K ; Tashiro, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b609t-b9f1532ded0b6e914df0e1d134ba1dc72e25b425e97ee282498966f0faec51493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Basal Ganglia - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Cats</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dominance, Cerebral - physiology</topic><topic>Eye Movements</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Rigidity - physiopathology</topic><topic>Muscles - innervation</topic><topic>Neck Muscles - innervation</topic><topic>Neurology</topic><topic>Supranuclear Palsy, Progressive - physiopathology</topic><topic>Tegmentum Mesencephali - physiopathology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukushima-Kudo, J</creatorcontrib><creatorcontrib>Fukushima, K</creatorcontrib><creatorcontrib>Tashiro, K</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukushima-Kudo, J</au><au>Fukushima, K</au><au>Tashiro, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rigidity and dorsiflexion of the neck in progressive supranuclear palsy and the interstitial nucleus of Cajal</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1987-09-01</date><risdate>1987</risdate><volume>50</volume><issue>9</issue><spage>1197</spage><epage>1203</epage><pages>1197-1203</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Rigidity and dorsiflexion of the neck are typical signs in progressive supranuclear palsy, but the responsible areas in the brain are unknown. To examine whether bilateral lesions of the interstitial nucleus of Cajal (INC) in the midbrain tegmentum contribute to the signs of patients with progressive supranuclear palsy, we have made bilateral INC lesions in cats and tried to correlate these studies with clinical and pathological data, including our case of progressive supranuclear palsy. Bilateral INC lesioned cats showed dorsiflexion of the neck and impairment of vertical eye movement, similar to progressive supranuclear palsy patients. Analysis of the previous clinical-pathological studies and our case have shown that dorsiflexion of the neck in progressive supranuclear palsy patients was correlated more with INC lesions than lesions of the basal ganglia.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>3668569</pmid><doi>10.1136/jnnp.50.9.1197</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Animals Basal Ganglia - physiopathology Biological and medical sciences Brain Mapping Cats Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dominance, Cerebral - physiology Eye Movements Humans Male Medical sciences Muscle Rigidity - physiopathology Muscles - innervation Neck Muscles - innervation Neurology Supranuclear Palsy, Progressive - physiopathology Tegmentum Mesencephali - physiopathology Tomography, X-Ray Computed |
| title | Rigidity and dorsiflexion of the neck in progressive supranuclear palsy and the interstitial nucleus of Cajal |
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