Plasma miR‐1254 as a predictive biomarker of chemosensitivity and a target of nucleic acid therapy in esophageal cancer

This study investigated novel tumor suppressor microRNAs (miRNAs) that decrease in plasma and predict chemosensitivity to neoadjuvant chemotherapy (NAC) for esophageal squamous cell carcinoma (ESCC) and revealed their usefulness as novel therapeutic agents. We selected four miRNA candidates (miR‐323...

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Veröffentlicht in:	Cancer science 2023-07, Vol.114 (7), p.3027-3040
Hauptverfasser:	Takashima, Yusuke, Komatsu, Shuhei, Ohashi, Takuma, Kiuchi, Jun, Nishibeppu, Keiji, Kamiya, Hajime, Arakawa, Hiroshi, Ishida, Ryo, Shimizu, Hiroki, Arita, Tomohiro, Konishi, Hirotaka, Shiozaki, Atsushi, Kubota, Takeshi, Fujiwara, Hitoshi, Otsuji, Eigo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Biomarkers, Tumor - genetics Cancer therapies Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Cell Line, Tumor chemosensitivity Chemotherapy Cisplatin Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology esophageal squamous cell carcinoma Esophageal Squamous Cell Carcinoma - drug therapy Esophageal Squamous Cell Carcinoma - genetics Gene Expression Regulation, Neoplastic Gene regulation Genomes Medical prognosis Mice MicroRNAs MicroRNAs - genetics miRNA Original ORIGINAL ARTICLES Patients Plasma Plasma levels plasma microRNA Prognosis Squamous cell carcinoma therapeutic agent Tumor suppressor genes
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