Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78

Oxygen (O2) sensing by the carotid body is critical for maintaining cardiorespiratory homeostasis during hypoxia. Hydrogen sulfide (H2S) signaling is implicated in carotid body activation by low O2. Here, we show that persulfidation of olfactory receptor 78 (Olfr78) by H2S is an integral component o...

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Veröffentlicht in:	Science advances 2023-07, Vol.9 (27), p.eadf3026
Hauptverfasser:	Peng, Ying-Jie, Nanduri, Jayasri, Wang, Ning, Kumar, Ganesh K, Bindokas, Vytautas, Paul, Bindu D, Chen, Xuanmao, Fox, Aaron P, Vignane, Thibaut, Filipovic, Milos R, Prabhakar, Nanduri R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine and Life Sciences Neurophysiology Physiology SciAdv r-articles
Online-Zugang:	Volltext
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