Proposed morbidity markers among Schistosoma mansoni patients
Fecal calprotectin (FC) and fecal occult blood (FOB) were suggested as potential inflammatory markers for assessing intestinal schistosomiasis morbidity that are conventionally detected through invasive methods. The present work aimed to evaluate FC and FOB as morbidity markers of infection before a...
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| Veröffentlicht in: | Tropical Parasitology 2023-01, Vol.13 (1), p.40-45 |
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| creator | Shehab, Amel Youssef Allam, Amal Farahat Saad, Awad Abd El Kader Osman, Mervat Mostafa Ibrahim, Heba Said Moneer, Esraa Abdelhamid Tolba, Mona Mohamed |
| description | Fecal calprotectin (FC) and fecal occult blood (FOB) were suggested as potential inflammatory markers for assessing intestinal schistosomiasis morbidity that are conventionally detected through invasive methods.
The present work aimed to evaluate FC and FOB as morbidity markers of
infection before and after praziquantel treatment.
A total of 205 stool samples (117 schoolchildren and 88 adults) were collected and examined by Kato Katz. A questionnaire enquiring about diarrhea, history of blood in stool, and abdominal pain was designed and applied.
prevalence rates were 20.5% and 11.36% among children and adults, respectively; the majority of cases had light infection intensity. FC and FOB were studied among 25 cured
cases (17 children and 8 adults) pre and one-month post treatment. Before treatment, six and four children of moderate and high
infection intensity tested positive for FC and FOB, respectively, all turning negative after treatment. FC showed borderline statistical significance before and after treatment among children. However, all adults tested negative for FC and FOB.
FC and FOB could be possibly used as morbidity monitoring tools for
infection in children with moderate and high infection intensity. |
| doi_str_mv | 10.4103/tp.tp_46_22 |
| format | Article |
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The present work aimed to evaluate FC and FOB as morbidity markers of
infection before and after praziquantel treatment.
A total of 205 stool samples (117 schoolchildren and 88 adults) were collected and examined by Kato Katz. A questionnaire enquiring about diarrhea, history of blood in stool, and abdominal pain was designed and applied.
prevalence rates were 20.5% and 11.36% among children and adults, respectively; the majority of cases had light infection intensity. FC and FOB were studied among 25 cured
cases (17 children and 8 adults) pre and one-month post treatment. Before treatment, six and four children of moderate and high
infection intensity tested positive for FC and FOB, respectively, all turning negative after treatment. FC showed borderline statistical significance before and after treatment among children. However, all adults tested negative for FC and FOB.
FC and FOB could be possibly used as morbidity monitoring tools for
infection in children with moderate and high infection intensity.</description><identifier>ISSN: 2229-5070</identifier><identifier>EISSN: 2229-7758</identifier><identifier>DOI: 10.4103/tp.tp_46_22</identifier><identifier>PMID: 37415754</identifier><language>eng</language><publisher>India: Medknow Publications & Media Pvt. Ltd</publisher><subject>Blood ; Children ; Diarrhea ; Feces ; Infections ; Inflammation ; Morbidity ; Original ; Praziquantel ; Schistosoma mansoni ; Schistosomiasis</subject><ispartof>Tropical Parasitology, 2023-01, Vol.13 (1), p.40-45</ispartof><rights>Copyright: © 2023 Tropical Parasitology.</rights><rights>2023. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2023 Tropical Parasitology 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366d-e797146c21867bb6665b3371d6c6676590f599128d5eb45e901018880f24dc4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321587/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321587/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37415754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shehab, Amel Youssef</creatorcontrib><creatorcontrib>Allam, Amal Farahat</creatorcontrib><creatorcontrib>Saad, Awad Abd El Kader</creatorcontrib><creatorcontrib>Osman, Mervat Mostafa</creatorcontrib><creatorcontrib>Ibrahim, Heba Said</creatorcontrib><creatorcontrib>Moneer, Esraa Abdelhamid</creatorcontrib><creatorcontrib>Tolba, Mona Mohamed</creatorcontrib><title>Proposed morbidity markers among Schistosoma mansoni patients</title><title>Tropical Parasitology</title><addtitle>Trop Parasitol</addtitle><description>Fecal calprotectin (FC) and fecal occult blood (FOB) were suggested as potential inflammatory markers for assessing intestinal schistosomiasis morbidity that are conventionally detected through invasive methods.
The present work aimed to evaluate FC and FOB as morbidity markers of
infection before and after praziquantel treatment.
A total of 205 stool samples (117 schoolchildren and 88 adults) were collected and examined by Kato Katz. A questionnaire enquiring about diarrhea, history of blood in stool, and abdominal pain was designed and applied.
prevalence rates were 20.5% and 11.36% among children and adults, respectively; the majority of cases had light infection intensity. FC and FOB were studied among 25 cured
cases (17 children and 8 adults) pre and one-month post treatment. Before treatment, six and four children of moderate and high
infection intensity tested positive for FC and FOB, respectively, all turning negative after treatment. FC showed borderline statistical significance before and after treatment among children. However, all adults tested negative for FC and FOB.
FC and FOB could be possibly used as morbidity monitoring tools for
infection in children with moderate and high infection intensity.</description><subject>Blood</subject><subject>Children</subject><subject>Diarrhea</subject><subject>Feces</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Morbidity</subject><subject>Original</subject><subject>Praziquantel</subject><subject>Schistosoma mansoni</subject><subject>Schistosomiasis</subject><issn>2229-5070</issn><issn>2229-7758</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVkEtLAzEUhYMottSu3MuAS5madzILESm-oKCgrkMyk2mjncmYTAv990b6QFf3Xu7hnMMHwDmCE4ogue67Sd8pyhXGR2CIMS5yIZg83u0MCjgA4xidgVCmC1F6CgZEUMQEo0Nw8xp856OtssYH4yrXb7JGhy8bYqYb386zt3LhYu-jb3T6tNG3Lut072zbxzNwUutltOPdHIGPh_v36VM-e3l8nt7N8pJwXuVWFCmYlxhJLozhnDNDiEAVLzkXnBWwZkWBsKyYNZTZAiKIpJSwxrQqqSYjcLv17VamsVWZsoNeqi641HWjvHbq_6d1CzX3a5UQYcSkSA6XO4fgv1c29urTr0KbSisssUAcUoKS6mqrKoOPMdj6EIGg-uWtEuw976S--NvqoN3TJT-qnnwu</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Shehab, Amel Youssef</creator><creator>Allam, Amal Farahat</creator><creator>Saad, Awad Abd El Kader</creator><creator>Osman, Mervat Mostafa</creator><creator>Ibrahim, Heba Said</creator><creator>Moneer, Esraa Abdelhamid</creator><creator>Tolba, Mona Mohamed</creator><general>Medknow Publications & Media Pvt. 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The present work aimed to evaluate FC and FOB as morbidity markers of
infection before and after praziquantel treatment.
A total of 205 stool samples (117 schoolchildren and 88 adults) were collected and examined by Kato Katz. A questionnaire enquiring about diarrhea, history of blood in stool, and abdominal pain was designed and applied.
prevalence rates were 20.5% and 11.36% among children and adults, respectively; the majority of cases had light infection intensity. FC and FOB were studied among 25 cured
cases (17 children and 8 adults) pre and one-month post treatment. Before treatment, six and four children of moderate and high
infection intensity tested positive for FC and FOB, respectively, all turning negative after treatment. FC showed borderline statistical significance before and after treatment among children. However, all adults tested negative for FC and FOB.
FC and FOB could be possibly used as morbidity monitoring tools for
infection in children with moderate and high infection intensity.</abstract><cop>India</cop><pub>Medknow Publications & Media Pvt. Ltd</pub><pmid>37415754</pmid><doi>10.4103/tp.tp_46_22</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Blood Children Diarrhea Feces Infections Inflammation Morbidity Original Praziquantel Schistosoma mansoni Schistosomiasis |
| title | Proposed morbidity markers among Schistosoma mansoni patients |
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