Effects of Smoking on Outcomes of Anti-Vascular Endothelial Growth Factor Therapy in Patients with Diabetic Macular Edema: A Retrospective Case-Control Study
To determine the effect of smoking on the response to anti-vascular endothelial growth factor (anti-VEGF) therapy treatment in patients with diabetic macular edema (DME). This is a retrospective case - control study that included 60 eyes with DME. Smoking habits were obtained from hospital records a...
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| Veröffentlicht in: | Middle East African journal of ophthalmology 2022-07, Vol.29 (3), p.116-121 |
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| creator | Al Saad, Mouna Shehadeh, Amin Hizzani, Asem Alzibdeh, Abdulla Alsubhi, Amani A Hamdan, Dina Alkubati, Ebtehal Meqbil, Jehad Hamadneh, Lina Ababneh, Osama |
| description | To determine the effect of smoking on the response to anti-vascular endothelial growth factor (anti-VEGF) therapy treatment in patients with diabetic macular edema (DME).
This is a retrospective case - control study that included 60 eyes with DME. Smoking habits were obtained from hospital records and patient recall. Patients were divided into two groups: the ever-smoker group and the never-smoker group. All patients received Intravitreal ranibizumab with three loading doses followed by PRN protocol and all were followed up for at least 1 year. Outcome measures were best-corrected visual acuity (BCVA), central retinal thickness (CRT) at the fovea, and number of visits.
Smoking was not associated with worse posttreatment visual acuity and was not found to influence the change in ocular coherence tomography measurement of central macular thickness and the change in BCVA (posttreatment minus pretreatment). There were no statistically significant differences in the duration of treatment or number of visits between two groups of patients the ever-smoker group and the never-smoker group (
> 0.05).
In this study, smoking status did not influence the treatment outcome of anti-VEGFs; however, smoking should be encouraged due to its well-known other systemic unwanted effects. |
| doi_str_mv | 10.4103/meajo.meajo_135_22 |
| format | Article |
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This is a retrospective case - control study that included 60 eyes with DME. Smoking habits were obtained from hospital records and patient recall. Patients were divided into two groups: the ever-smoker group and the never-smoker group. All patients received Intravitreal ranibizumab with three loading doses followed by PRN protocol and all were followed up for at least 1 year. Outcome measures were best-corrected visual acuity (BCVA), central retinal thickness (CRT) at the fovea, and number of visits.
Smoking was not associated with worse posttreatment visual acuity and was not found to influence the change in ocular coherence tomography measurement of central macular thickness and the change in BCVA (posttreatment minus pretreatment). There were no statistically significant differences in the duration of treatment or number of visits between two groups of patients the ever-smoker group and the never-smoker group (
> 0.05).
In this study, smoking status did not influence the treatment outcome of anti-VEGFs; however, smoking should be encouraged due to its well-known other systemic unwanted effects.</description><identifier>ISSN: 0974-9233</identifier><identifier>ISSN: 0975-1599</identifier><identifier>EISSN: 0975-1599</identifier><identifier>EISSN: 0974-9233</identifier><identifier>DOI: 10.4103/meajo.meajo_135_22</identifier><identifier>PMID: 37408720</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Angiogenesis Inhibitors - therapeutic use ; Care and treatment ; Case-Control Studies ; Diabetes ; Diabetes Mellitus - drug therapy ; Diabetic Retinopathy - complications ; Diabetic Retinopathy - diagnosis ; Diabetic Retinopathy - drug therapy ; Dropsy ; Edema ; Endothelial Growth Factors - therapeutic use ; Humans ; Intravitreal Injections ; Macular Edema - diagnosis ; Macular Edema - drug therapy ; Macular Edema - etiology ; Medical records ; Original ; Patient outcomes ; Ranibizumab ; Retrospective Studies ; Smoking - epidemiology ; Tomography, Optical Coherence ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A ; Visual acuity</subject><ispartof>Middle East African journal of ophthalmology, 2022-07, Vol.29 (3), p.116-121</ispartof><rights>Copyright: © 2023 Middle East African Journal of Ophthalmology.</rights><rights>COPYRIGHT 2022 Medknow Publications and Media Pvt. Ltd.</rights><rights>2022. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2023 Middle East African Journal of Ophthalmology 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c508t-d839eb29881747589f779cb010dca2f789f9e273d45bae66ecc089a39f11cc8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319076/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319076/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37408720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al Saad, Mouna</creatorcontrib><creatorcontrib>Shehadeh, Amin</creatorcontrib><creatorcontrib>Hizzani, Asem</creatorcontrib><creatorcontrib>Alzibdeh, Abdulla</creatorcontrib><creatorcontrib>Alsubhi, Amani A</creatorcontrib><creatorcontrib>Hamdan, Dina</creatorcontrib><creatorcontrib>Alkubati, Ebtehal</creatorcontrib><creatorcontrib>Meqbil, Jehad</creatorcontrib><creatorcontrib>Hamadneh, Lina</creatorcontrib><creatorcontrib>Ababneh, Osama</creatorcontrib><title>Effects of Smoking on Outcomes of Anti-Vascular Endothelial Growth Factor Therapy in Patients with Diabetic Macular Edema: A Retrospective Case-Control Study</title><title>Middle East African journal of ophthalmology</title><addtitle>Middle East Afr J Ophthalmol</addtitle><description>To determine the effect of smoking on the response to anti-vascular endothelial growth factor (anti-VEGF) therapy treatment in patients with diabetic macular edema (DME).
This is a retrospective case - control study that included 60 eyes with DME. Smoking habits were obtained from hospital records and patient recall. Patients were divided into two groups: the ever-smoker group and the never-smoker group. All patients received Intravitreal ranibizumab with three loading doses followed by PRN protocol and all were followed up for at least 1 year. Outcome measures were best-corrected visual acuity (BCVA), central retinal thickness (CRT) at the fovea, and number of visits.
Smoking was not associated with worse posttreatment visual acuity and was not found to influence the change in ocular coherence tomography measurement of central macular thickness and the change in BCVA (posttreatment minus pretreatment). There were no statistically significant differences in the duration of treatment or number of visits between two groups of patients the ever-smoker group and the never-smoker group (
> 0.05).
In this study, smoking status did not influence the treatment outcome of anti-VEGFs; however, smoking should be encouraged due to its well-known other systemic unwanted effects.</description><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetic Retinopathy - complications</subject><subject>Diabetic Retinopathy - diagnosis</subject><subject>Diabetic Retinopathy - drug therapy</subject><subject>Dropsy</subject><subject>Edema</subject><subject>Endothelial Growth Factors - therapeutic use</subject><subject>Humans</subject><subject>Intravitreal Injections</subject><subject>Macular Edema - diagnosis</subject><subject>Macular Edema - drug therapy</subject><subject>Macular Edema - etiology</subject><subject>Medical records</subject><subject>Original</subject><subject>Patient outcomes</subject><subject>Ranibizumab</subject><subject>Retrospective Studies</subject><subject>Smoking - epidemiology</subject><subject>Tomography, Optical Coherence</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Visual acuity</subject><issn>0974-9233</issn><issn>0975-1599</issn><issn>0975-1599</issn><issn>0974-9233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UttuEzEQXSEQrUJ_gAdkCQnxssGX3djmBUUhLUhFRbTwajne2azDrp2uva36MfwrzoUqQQhbsq2ZM8dzOVn2kuBxQTB714Fe-fH2VISVitIn2SmWvMxJKeXT7bvIJWXsJDsLYYU3i2NeiufZCeMFFpzi0-zXvK7BxIB8ja47_9O6JfIOXQ3R-A625qmLNv-hgxla3aO5q3xsoLW6RRe9v48NOtcm-h7dNNDr9QOyDn3V0YJLrPc2-T9avYBoDfqi9xwVdPo9mqJvEHsf1ikBewdopgPkM--SrUXXcageXmTPat0GONvfo-z7-fxm9im_vLr4PJte5qbEIuaVYBIWVApBeJEqlDXn0iwwwZXRtObJIIFyVhXlQsNkAsZgITWTNSHGiJqNsg873vWw6KAyKfdet2rd2073D8prq449zjZq6e9UmgSRmE8Sw9s9Q-9vBwhRdTYYaFvtwA9BUcGYlKKQMkFf_wVd-aF3qT7FSFFyOuH4vygqKCcTXLAD1FK3oKyrfUrPbL5WU16ygpRlSnGUjf-BSjvNwRrvoLbJfhTw5iCgAd3GJvh2iNa7cAykO6BJcww91I89I1htdKp2Cj3UaQp6ddjtx5A_qmS_AaiF5d8</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Al Saad, Mouna</creator><creator>Shehadeh, Amin</creator><creator>Hizzani, Asem</creator><creator>Alzibdeh, Abdulla</creator><creator>Alsubhi, Amani A</creator><creator>Hamdan, Dina</creator><creator>Alkubati, Ebtehal</creator><creator>Meqbil, Jehad</creator><creator>Hamadneh, Lina</creator><creator>Ababneh, Osama</creator><general>Medknow Publications and Media Pvt. 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therapeutic use</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetic Retinopathy - complications</topic><topic>Diabetic Retinopathy - diagnosis</topic><topic>Diabetic Retinopathy - drug therapy</topic><topic>Dropsy</topic><topic>Edema</topic><topic>Endothelial Growth Factors - therapeutic use</topic><topic>Humans</topic><topic>Intravitreal Injections</topic><topic>Macular Edema - diagnosis</topic><topic>Macular Edema - drug therapy</topic><topic>Macular Edema - etiology</topic><topic>Medical records</topic><topic>Original</topic><topic>Patient outcomes</topic><topic>Ranibizumab</topic><topic>Retrospective Studies</topic><topic>Smoking - epidemiology</topic><topic>Tomography, Optical Coherence</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al Saad, Mouna</creatorcontrib><creatorcontrib>Shehadeh, Amin</creatorcontrib><creatorcontrib>Hizzani, Asem</creatorcontrib><creatorcontrib>Alzibdeh, Abdulla</creatorcontrib><creatorcontrib>Alsubhi, Amani A</creatorcontrib><creatorcontrib>Hamdan, Dina</creatorcontrib><creatorcontrib>Alkubati, Ebtehal</creatorcontrib><creatorcontrib>Meqbil, Jehad</creatorcontrib><creatorcontrib>Hamadneh, Lina</creatorcontrib><creatorcontrib>Ababneh, Osama</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Middle East African journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al Saad, Mouna</au><au>Shehadeh, Amin</au><au>Hizzani, Asem</au><au>Alzibdeh, Abdulla</au><au>Alsubhi, Amani A</au><au>Hamdan, Dina</au><au>Alkubati, Ebtehal</au><au>Meqbil, Jehad</au><au>Hamadneh, Lina</au><au>Ababneh, Osama</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Smoking on Outcomes of Anti-Vascular Endothelial Growth Factor Therapy in Patients with Diabetic Macular Edema: A Retrospective Case-Control Study</atitle><jtitle>Middle East African journal of ophthalmology</jtitle><addtitle>Middle East Afr J Ophthalmol</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>29</volume><issue>3</issue><spage>116</spage><epage>121</epage><pages>116-121</pages><issn>0974-9233</issn><issn>0975-1599</issn><eissn>0975-1599</eissn><eissn>0974-9233</eissn><abstract>To determine the effect of smoking on the response to anti-vascular endothelial growth factor (anti-VEGF) therapy treatment in patients with diabetic macular edema (DME).
This is a retrospective case - control study that included 60 eyes with DME. Smoking habits were obtained from hospital records and patient recall. Patients were divided into two groups: the ever-smoker group and the never-smoker group. All patients received Intravitreal ranibizumab with three loading doses followed by PRN protocol and all were followed up for at least 1 year. Outcome measures were best-corrected visual acuity (BCVA), central retinal thickness (CRT) at the fovea, and number of visits.
Smoking was not associated with worse posttreatment visual acuity and was not found to influence the change in ocular coherence tomography measurement of central macular thickness and the change in BCVA (posttreatment minus pretreatment). There were no statistically significant differences in the duration of treatment or number of visits between two groups of patients the ever-smoker group and the never-smoker group (
> 0.05).
In this study, smoking status did not influence the treatment outcome of anti-VEGFs; however, smoking should be encouraged due to its well-known other systemic unwanted effects.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>37408720</pmid><doi>10.4103/meajo.meajo_135_22</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Inhibitors - therapeutic use Care and treatment Case-Control Studies Diabetes Diabetes Mellitus - drug therapy Diabetic Retinopathy - complications Diabetic Retinopathy - diagnosis Diabetic Retinopathy - drug therapy Dropsy Edema Endothelial Growth Factors - therapeutic use Humans Intravitreal Injections Macular Edema - diagnosis Macular Edema - drug therapy Macular Edema - etiology Medical records Original Patient outcomes Ranibizumab Retrospective Studies Smoking - epidemiology Tomography, Optical Coherence Vascular endothelial growth factor Vascular Endothelial Growth Factor A Visual acuity |
| title | Effects of Smoking on Outcomes of Anti-Vascular Endothelial Growth Factor Therapy in Patients with Diabetic Macular Edema: A Retrospective Case-Control Study |
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