First report of Onchocerca lupi from Israel and confirmation of two genotypes circulating among canine, feline and human hosts
Onchocerca lupi is a parasitic filarioid and the causative agent of canine ocular onchocercosis, a zoonotic disease of domestic dogs with sporadic reports in humans. A 13-year-old dog with no travel history outside of Israel was presented to an ophthalmology veterinary clinic in Israel with severe r...
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| Veröffentlicht in: | Parasitology 2020-12, Vol.147 (14), p.1723-1727 |
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| description | Onchocerca lupi is a parasitic filarioid and the causative agent of canine ocular onchocercosis, a zoonotic disease of domestic dogs with sporadic reports in humans. A 13-year-old dog with no travel history outside of Israel was presented to an ophthalmology veterinary clinic in Israel with severe right ocular and periocular disease. After surgical exploration, thin helminths were removed from the dorsal sclera of the eye and identified as Onchocerca lupi by polymerase chain reaction according to the cytochrome c oxidase subunit I (cox1), reduced nicotinamide adenine dinucleotide dehydrogenase subunit 5 (nad5) and 12S rRNA genes. Phylogenetic trees and haplotype networks of the cox1 and nad5 genes confirmed the circulation of two genotypes: genotype 1 with worms from dogs, cats and humans from both the Old and New Worlds, and genotype 2 with specimens from Portugal and Spain. The Israeli sequences clustered in genotype 1 and were identical to O. lupi from the USA. Evidence of two genotypes separated geographically sheds light on the phylogeography and evolution of this zoonotic pathogen, and suggests a diverse pathology observed in different regions of the world. |
| doi_str_mv | 10.1017/S0031182020001560 |
| format | Article |
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A 13-year-old dog with no travel history outside of Israel was presented to an ophthalmology veterinary clinic in Israel with severe right ocular and periocular disease. After surgical exploration, thin helminths were removed from the dorsal sclera of the eye and identified as Onchocerca lupi by polymerase chain reaction according to the cytochrome c oxidase subunit I (cox1), reduced nicotinamide adenine dinucleotide dehydrogenase subunit 5 (nad5) and 12S rRNA genes. Phylogenetic trees and haplotype networks of the cox1 and nad5 genes confirmed the circulation of two genotypes: genotype 1 with worms from dogs, cats and humans from both the Old and New Worlds, and genotype 2 with specimens from Portugal and Spain. The Israeli sequences clustered in genotype 1 and were identical to O. lupi from the USA. Evidence of two genotypes separated geographically sheds light on the phylogeography and evolution of this zoonotic pathogen, and suggests a diverse pathology observed in different regions of the world.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182020001560</identifier><identifier>PMID: 32829715</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adenine ; Animals ; Cat Diseases - parasitology ; Cats ; Cytochrome-c oxidase ; Cytochromes ; Deoxyribonucleic acid ; DNA ; Dog Diseases - diagnosis ; Dog Diseases - parasitology ; Dog Diseases - surgery ; Dogs ; Domestic animals ; Genes ; Genotype ; Genotype & phenotype ; Genotypes ; Haplotypes ; Helminth Proteins - analysis ; Humans ; Israel ; NAD ; Nicotinamide ; Nicotinamide adenine dinucleotide ; Onchocerca ; Onchocerca - genetics ; Onchocerca - isolation & purification ; Onchocerciasis, Ocular - diagnosis ; Onchocerciasis, Ocular - parasitology ; Onchocerciasis, Ocular - surgery ; Onchocerciasis, Ocular - veterinary ; Ophthalmology ; Phylogenetics ; Phylogeny ; Polymerase chain reaction ; rRNA 12S ; Veterinary medicine ; Zoonoses</subject><ispartof>Parasitology, 2020-12, Vol.147 (14), p.1723-1727</ispartof><rights>Copyright © The Author(s) 2020. Published by Cambridge University Press</rights><rights>The Author(s) 2020 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-c180560b3b7db07454a2a52d1476217dd2d69f5a0e8dfa409b3b5691f34cc75d3</citedby><cites>FETCH-LOGICAL-c429t-c180560b3b7db07454a2a52d1476217dd2d69f5a0e8dfa409b3b5691f34cc75d3</cites><orcidid>0000-0002-7549-1305 ; 0000-0003-2007-7198</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317758/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182020001560/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,725,778,782,883,27907,27908,53774,53776,55611</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32829715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rojas, A</creatorcontrib><creatorcontrib>Salant, H</creatorcontrib><creatorcontrib>Yasur-Landau, D</creatorcontrib><creatorcontrib>Tsarfati, H</creatorcontrib><creatorcontrib>Baneth, G</creatorcontrib><title>First report of Onchocerca lupi from Israel and confirmation of two genotypes circulating among canine, feline and human hosts</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>Onchocerca lupi is a parasitic filarioid and the causative agent of canine ocular onchocercosis, a zoonotic disease of domestic dogs with sporadic reports in humans. A 13-year-old dog with no travel history outside of Israel was presented to an ophthalmology veterinary clinic in Israel with severe right ocular and periocular disease. After surgical exploration, thin helminths were removed from the dorsal sclera of the eye and identified as Onchocerca lupi by polymerase chain reaction according to the cytochrome c oxidase subunit I (cox1), reduced nicotinamide adenine dinucleotide dehydrogenase subunit 5 (nad5) and 12S rRNA genes. Phylogenetic trees and haplotype networks of the cox1 and nad5 genes confirmed the circulation of two genotypes: genotype 1 with worms from dogs, cats and humans from both the Old and New Worlds, and genotype 2 with specimens from Portugal and Spain. The Israeli sequences clustered in genotype 1 and were identical to O. lupi from the USA. Evidence of two genotypes separated geographically sheds light on the phylogeography and evolution of this zoonotic pathogen, and suggests a diverse pathology observed in different regions of the world.</description><subject>Adenine</subject><subject>Animals</subject><subject>Cat Diseases - parasitology</subject><subject>Cats</subject><subject>Cytochrome-c oxidase</subject><subject>Cytochromes</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - parasitology</subject><subject>Dog Diseases - surgery</subject><subject>Dogs</subject><subject>Domestic animals</subject><subject>Genes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Helminth Proteins - analysis</subject><subject>Humans</subject><subject>Israel</subject><subject>NAD</subject><subject>Nicotinamide</subject><subject>Nicotinamide adenine dinucleotide</subject><subject>Onchocerca</subject><subject>Onchocerca - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rojas, A</au><au>Salant, H</au><au>Yasur-Landau, D</au><au>Tsarfati, H</au><au>Baneth, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First report of Onchocerca lupi from Israel and confirmation of two genotypes circulating among canine, feline and human hosts</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>147</volume><issue>14</issue><spage>1723</spage><epage>1727</epage><pages>1723-1727</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><abstract>Onchocerca lupi is a parasitic filarioid and the causative agent of canine ocular onchocercosis, a zoonotic disease of domestic dogs with sporadic reports in humans. A 13-year-old dog with no travel history outside of Israel was presented to an ophthalmology veterinary clinic in Israel with severe right ocular and periocular disease. After surgical exploration, thin helminths were removed from the dorsal sclera of the eye and identified as Onchocerca lupi by polymerase chain reaction according to the cytochrome c oxidase subunit I (cox1), reduced nicotinamide adenine dinucleotide dehydrogenase subunit 5 (nad5) and 12S rRNA genes. Phylogenetic trees and haplotype networks of the cox1 and nad5 genes confirmed the circulation of two genotypes: genotype 1 with worms from dogs, cats and humans from both the Old and New Worlds, and genotype 2 with specimens from Portugal and Spain. The Israeli sequences clustered in genotype 1 and were identical to O. lupi from the USA. Evidence of two genotypes separated geographically sheds light on the phylogeography and evolution of this zoonotic pathogen, and suggests a diverse pathology observed in different regions of the world.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>32829715</pmid><doi>10.1017/S0031182020001560</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-7549-1305</orcidid><orcidid>https://orcid.org/0000-0003-2007-7198</orcidid></addata></record> |
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| subjects | Adenine Animals Cat Diseases - parasitology Cats Cytochrome-c oxidase Cytochromes Deoxyribonucleic acid DNA Dog Diseases - diagnosis Dog Diseases - parasitology Dog Diseases - surgery Dogs Domestic animals Genes Genotype Genotype & phenotype Genotypes Haplotypes Helminth Proteins - analysis Humans Israel NAD Nicotinamide Nicotinamide adenine dinucleotide Onchocerca Onchocerca - genetics Onchocerca - isolation & purification Onchocerciasis, Ocular - diagnosis Onchocerciasis, Ocular - parasitology Onchocerciasis, Ocular - surgery Onchocerciasis, Ocular - veterinary Ophthalmology Phylogenetics Phylogeny Polymerase chain reaction rRNA 12S Veterinary medicine Zoonoses |
| title | First report of Onchocerca lupi from Israel and confirmation of two genotypes circulating among canine, feline and human hosts |
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