Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice
In this study, we evaluated the efficacy, expressed as a mean weight decrease of the whole echinococcal cyst mass, of novel benzimidazole salt formulations in a murine Echinococcus granulosus infection model. BALB/c mice were intraperitoneally infected with protoscoleces of E. granulosus (genotype G...
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| Veröffentlicht in: | Parasitology 2020-11, Vol.147 (13), p.1425-1432 |
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| creator | Vural, G. Yardimci, M. Kocak, M. Yasar, T. Ö. Kurt, A. Harem, I. S. Carradori, S. Sciamanna, I. Siles-Lucas, M. Fabiani, M. Hemphill, A. Lundström-Stadelmann, B. Cirilli, R. Casulli, A. |
| description | In this study, we evaluated the efficacy, expressed as a mean weight decrease of the whole echinococcal cyst mass, of novel benzimidazole salt formulations in a murine Echinococcus granulosus infection model. BALB/c mice were intraperitoneally infected with protoscoleces of E. granulosus (genotype G1). At 9 months post-infection, treatment with albendazole (ABZ), ricobendazole (RBZ) salt formulations, and RBZ enantiomer salts (R)-(+)-RBZ-Na and (S)-(−)-RBZ-Na formulations were initiated. Drugs were orally applied by gavage at 10 mg kg−1 body weight per day during 30 days. Experimental treatments with benzimidazole sodium salts resulted in a significant reduction of the weight of cysts compared to conventional ABZ treatment, except for the (S)-(−)-RBZ-Na enantiomer formulation. Scanning electron microscopy and histological inspection revealed that treatments impacted not only the structural integrity of the parasite tissue in the germinal layer, but also induced alterations in the laminated layer. Overall, these results demonstrate the improved efficacy of benzimidazole salt formulations compared to conventional ABZ treatment in experimental murine cystic echinococcosis. |
| doi_str_mv | 10.1017/S0031182020001225 |
| format | Article |
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Ö. ; Kurt, A. ; Harem, I. S. ; Carradori, S. ; Sciamanna, I. ; Siles-Lucas, M. ; Fabiani, M. ; Hemphill, A. ; Lundström-Stadelmann, B. ; Cirilli, R. ; Casulli, A.</creator><creatorcontrib>Vural, G. ; Yardimci, M. ; Kocak, M. ; Yasar, T. Ö. ; Kurt, A. ; Harem, I. S. ; Carradori, S. ; Sciamanna, I. ; Siles-Lucas, M. ; Fabiani, M. ; Hemphill, A. ; Lundström-Stadelmann, B. ; Cirilli, R. ; Casulli, A.</creatorcontrib><description>In this study, we evaluated the efficacy, expressed as a mean weight decrease of the whole echinococcal cyst mass, of novel benzimidazole salt formulations in a murine Echinococcus granulosus infection model. BALB/c mice were intraperitoneally infected with protoscoleces of E. granulosus (genotype G1). At 9 months post-infection, treatment with albendazole (ABZ), ricobendazole (RBZ) salt formulations, and RBZ enantiomer salts (R)-(+)-RBZ-Na and (S)-(−)-RBZ-Na formulations were initiated. Drugs were orally applied by gavage at 10 mg kg−1 body weight per day during 30 days. Experimental treatments with benzimidazole sodium salts resulted in a significant reduction of the weight of cysts compared to conventional ABZ treatment, except for the (S)-(−)-RBZ-Na enantiomer formulation. Scanning electron microscopy and histological inspection revealed that treatments impacted not only the structural integrity of the parasite tissue in the germinal layer, but also induced alterations in the laminated layer. Overall, these results demonstrate the improved efficacy of benzimidazole salt formulations compared to conventional ABZ treatment in experimental murine cystic echinococcosis.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182020001225</identifier><identifier>PMID: 32729453</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Abdomen ; Albendazole ; Albendazole - administration & dosage ; Albendazole - analogs & derivatives ; Anaphylaxis ; Animals ; Anticestodal Agents - administration & dosage ; Benzimidazoles ; Body weight ; Cysts ; Drugs ; Echinococcosis ; Echinococcosis - drug therapy ; Echinococcus granulosus - drug effects ; Enantiomers ; Ethanol ; Female ; Genotype & phenotype ; Genotypes ; Infections ; Inspection ; Mice ; Mice, Inbred BALB C ; Parasites ; Parasitic diseases ; Pharmaceutical industry ; Salt ; Salts ; Salts - chemistry ; Scanning electron microscopy ; Sodium salts ; Structural integrity</subject><ispartof>Parasitology, 2020-11, Vol.147 (13), p.1425-1432</ispartof><rights>Copyright © The Author(s), 2020. Published by Cambridge University Press</rights><rights>The Author(s) 2020 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-58f1f3b0a9b04e2bdd1946a4e5b88c4989d56e1b46b545450b79a8c7365d8b203</citedby><cites>FETCH-LOGICAL-c472t-58f1f3b0a9b04e2bdd1946a4e5b88c4989d56e1b46b545450b79a8c7365d8b203</cites><orcidid>0000-0001-9183-7591 ; 0000-0002-0622-2128 ; 0000-0003-2672-5766</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317756/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182020001225/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,723,776,780,881,27903,27904,53769,53771,55606</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32729453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vural, G.</creatorcontrib><creatorcontrib>Yardimci, M.</creatorcontrib><creatorcontrib>Kocak, M.</creatorcontrib><creatorcontrib>Yasar, T. Ö.</creatorcontrib><creatorcontrib>Kurt, A.</creatorcontrib><creatorcontrib>Harem, I. S.</creatorcontrib><creatorcontrib>Carradori, S.</creatorcontrib><creatorcontrib>Sciamanna, I.</creatorcontrib><creatorcontrib>Siles-Lucas, M.</creatorcontrib><creatorcontrib>Fabiani, M.</creatorcontrib><creatorcontrib>Hemphill, A.</creatorcontrib><creatorcontrib>Lundström-Stadelmann, B.</creatorcontrib><creatorcontrib>Cirilli, R.</creatorcontrib><creatorcontrib>Casulli, A.</creatorcontrib><title>Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>In this study, we evaluated the efficacy, expressed as a mean weight decrease of the whole echinococcal cyst mass, of novel benzimidazole salt formulations in a murine Echinococcus granulosus infection model. BALB/c mice were intraperitoneally infected with protoscoleces of E. granulosus (genotype G1). At 9 months post-infection, treatment with albendazole (ABZ), ricobendazole (RBZ) salt formulations, and RBZ enantiomer salts (R)-(+)-RBZ-Na and (S)-(−)-RBZ-Na formulations were initiated. Drugs were orally applied by gavage at 10 mg kg−1 body weight per day during 30 days. Experimental treatments with benzimidazole sodium salts resulted in a significant reduction of the weight of cysts compared to conventional ABZ treatment, except for the (S)-(−)-RBZ-Na enantiomer formulation. Scanning electron microscopy and histological inspection revealed that treatments impacted not only the structural integrity of the parasite tissue in the germinal layer, but also induced alterations in the laminated layer. Overall, these results demonstrate the improved efficacy of benzimidazole salt formulations compared to conventional ABZ treatment in experimental murine cystic echinococcosis.</description><subject>Abdomen</subject><subject>Albendazole</subject><subject>Albendazole - administration & dosage</subject><subject>Albendazole - analogs & derivatives</subject><subject>Anaphylaxis</subject><subject>Animals</subject><subject>Anticestodal Agents - administration & dosage</subject><subject>Benzimidazoles</subject><subject>Body weight</subject><subject>Cysts</subject><subject>Drugs</subject><subject>Echinococcosis</subject><subject>Echinococcosis - drug therapy</subject><subject>Echinococcus granulosus - drug effects</subject><subject>Enantiomers</subject><subject>Ethanol</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Infections</subject><subject>Inspection</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Pharmaceutical industry</subject><subject>Salt</subject><subject>Salts</subject><subject>Salts - chemistry</subject><subject>Scanning electron microscopy</subject><subject>Sodium salts</subject><subject>Structural integrity</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kUuPFCEUhYnROO3oD3BjSNy4KQWKomBlzGR8JJO4UNcEqEsPEwpaqJqx_fXSmXZ8xbAg4Xz33HO5CD2l5CUldHz1iZCeUskII4RQxoZ7aEO5UJ2kgt5Hm4PcHfQT9KjWqwaJXrCH6KRnI1N86Dfo5tz74Izb4-xxytcQsYkW0mS-5wi4mrhgn8u8RrOEnCo2WxNSXXAFlxtV9tjt6xIcBncZUnbZuVxDxSFh-LaDEmZIi4lx3148uAUmPAcHj9EDb2KFJ8f7FH15e_757H138fHdh7M3F53jI1u6QXrqe0uMsoQDs9NEFReGw2CldFxJNQ0CqOXCDrwdYkdlpBt7MUzSMtKfote3vrvVzjC5FqaYqHctV8uuswn6TyWFS73N15q2vxvHQTSHF0eHkr-uUBc9h-ogRpMgr1UzzhQRlHHe0Od_oVd5LanN1yhB5aCaZ6PoLeVKrrWAv0tDiT7sVf-z11bz7Pcx7ip-LrIB_dHUzLaEaQu_ev_f9gcFQq8y</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Vural, G.</creator><creator>Yardimci, M.</creator><creator>Kocak, M.</creator><creator>Yasar, T. 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Ö.</au><au>Kurt, A.</au><au>Harem, I. S.</au><au>Carradori, S.</au><au>Sciamanna, I.</au><au>Siles-Lucas, M.</au><au>Fabiani, M.</au><au>Hemphill, A.</au><au>Lundström-Stadelmann, B.</au><au>Cirilli, R.</au><au>Casulli, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>147</volume><issue>13</issue><spage>1425</spage><epage>1432</epage><pages>1425-1432</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><abstract>In this study, we evaluated the efficacy, expressed as a mean weight decrease of the whole echinococcal cyst mass, of novel benzimidazole salt formulations in a murine Echinococcus granulosus infection model. BALB/c mice were intraperitoneally infected with protoscoleces of E. granulosus (genotype G1). At 9 months post-infection, treatment with albendazole (ABZ), ricobendazole (RBZ) salt formulations, and RBZ enantiomer salts (R)-(+)-RBZ-Na and (S)-(−)-RBZ-Na formulations were initiated. Drugs were orally applied by gavage at 10 mg kg−1 body weight per day during 30 days. Experimental treatments with benzimidazole sodium salts resulted in a significant reduction of the weight of cysts compared to conventional ABZ treatment, except for the (S)-(−)-RBZ-Na enantiomer formulation. Scanning electron microscopy and histological inspection revealed that treatments impacted not only the structural integrity of the parasite tissue in the germinal layer, but also induced alterations in the laminated layer. Overall, these results demonstrate the improved efficacy of benzimidazole salt formulations compared to conventional ABZ treatment in experimental murine cystic echinococcosis.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>32729453</pmid><doi>10.1017/S0031182020001225</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9183-7591</orcidid><orcidid>https://orcid.org/0000-0002-0622-2128</orcidid><orcidid>https://orcid.org/0000-0003-2672-5766</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Parasitology, 2020-11, Vol.147 (13), p.1425-1432 |
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| source | MEDLINE; PubMed Central; Cambridge University Press Journals Complete |
| subjects | Abdomen Albendazole Albendazole - administration & dosage Albendazole - analogs & derivatives Anaphylaxis Animals Anticestodal Agents - administration & dosage Benzimidazoles Body weight Cysts Drugs Echinococcosis Echinococcosis - drug therapy Echinococcus granulosus - drug effects Enantiomers Ethanol Female Genotype & phenotype Genotypes Infections Inspection Mice Mice, Inbred BALB C Parasites Parasitic diseases Pharmaceutical industry Salt Salts Salts - chemistry Scanning electron microscopy Sodium salts Structural integrity |
| title | Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice |
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