Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice

Obesity is a risk factor for colorectal cancer (CRC). The role of gut microbiota in mediating the cancer-promoting effect of obesity is unknown. Azoxymethane (AOM)-treated, ApcMin/+ and germ-free mice were gavaged with feces from obese individuals and control subjects respectively. The colonic tumor...

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Veröffentlicht in:	EBioMedicine 2023-07, Vol.93, p.104670-104670, Article 104670
Hauptverfasser:	Kang, Xing, Ng, Siu-Kin, Liu, Changan, Lin, Yufeng, Zhou, Yunfei, Kwong, Thomas N.Y., Ni, Yunbi, Lam, Thomas Y.T., Wu, William K.K., Wei, Hong, Sung, Joseph J.Y., Yu, Jun, Wong, Sunny H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Colorectal cancer Gut barrier Microbiota Obesity Pro-inflammation
Online-Zugang:	Volltext
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