Diversity of cells and signals in the cardiovascular system
This white paper is the outcome of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. This biannual meeting aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importan...
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| Veröffentlicht in: | The Journal of physiology 2023-07, Vol.601 (13), p.2547-2592 |
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| creator | Grandi, Eleonora Navedo, Manuel F. Saucerman, Jeffrey J. Bers, Donald M. Chiamvimonvat, Nipavan Dixon, Rose E. Dobrev, Dobromir Gomez, Ana M. Harraz, Osama F. Hegyi, Bence Jones, David K. Krogh‐Madsen, Trine Murfee, Walter Lee Nystoriak, Matthew A. Posnack, Nikki G. Ripplinger, Crystal M. Veeraraghavan, Rengasayee Weinberg, Seth |
| description | This white paper is the outcome of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. This biannual meeting aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2022 Symposium was ‘Cell Diversity in the Cardiovascular System, cell‐autonomous and cell–cell signalling’. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies, and challenges in examining cell and signal diversity, co‐ordination and interrelationships involved in cardiovascular function. This paper originates from the topics of formal presentations and informal discussions from the Symposium, which aimed to develop a holistic view of how the multiple cell types in the cardiovascular system integrate to influence cardiovascular function, disease progression and therapeutic strategies. The first section describes the major cell types (e.g. cardiomyocytes, vascular smooth muscle and endothelial cells, fibroblasts, neurons, immune cells, etc.) and the signals involved in cardiovascular function. The second section emphasizes the complexity at the subcellular, cellular and system levels in the context of cardiovascular development, ageing and disease. Finally, the third section surveys the technological innovations that allow the interrogation of this diversity and advancing our understanding of the integrated cardiovascular function and dysfunction.
figure legend This white paper discusses the cell diversity, co‐ordination and interaction patterns that are critical for robust cardiovascular function. We identify the major cell types and signals involved in cardiovascular function and emphasize the complexity at the subcellular, cellular and system levels that motivate both challenges and opportunities for researchers. A survey of recent advances enabled by innovative experimental and computational modelling approaches serve to guide researchers moving forward. |
| doi_str_mv | 10.1113/JP284011 |
| format | Article |
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figure legend This white paper discusses the cell diversity, co‐ordination and interaction patterns that are critical for robust cardiovascular function. We identify the major cell types and signals involved in cardiovascular function and emphasize the complexity at the subcellular, cellular and system levels that motivate both challenges and opportunities for researchers. A survey of recent advances enabled by innovative experimental and computational modelling approaches serve to guide researchers moving forward.</description><identifier>ISSN: 0022-3751</identifier><identifier>ISSN: 1469-7793</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/JP284011</identifier><identifier>PMID: 36744541</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>animal models ; Arrhythmia ; Arrhythmias, Cardiac ; Cardiomyocytes ; Cardiovascular Diseases ; Cardiovascular system ; Endothelial Cells ; Fibroblasts ; Humans ; ion channels ; ion transporters ; Life Sciences ; Mathematical models ; modelling ; Myocytes, Cardiac ; omics ; signal transduction ; Smooth muscle</subject><ispartof>The Journal of physiology, 2023-07, Vol.601 (13), p.2547-2592</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd on behalf of The Physiological Society.</rights><rights>2023 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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This biannual meeting aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2022 Symposium was ‘Cell Diversity in the Cardiovascular System, cell‐autonomous and cell–cell signalling’. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies, and challenges in examining cell and signal diversity, co‐ordination and interrelationships involved in cardiovascular function. This paper originates from the topics of formal presentations and informal discussions from the Symposium, which aimed to develop a holistic view of how the multiple cell types in the cardiovascular system integrate to influence cardiovascular function, disease progression and therapeutic strategies. The first section describes the major cell types (e.g. cardiomyocytes, vascular smooth muscle and endothelial cells, fibroblasts, neurons, immune cells, etc.) and the signals involved in cardiovascular function. The second section emphasizes the complexity at the subcellular, cellular and system levels in the context of cardiovascular development, ageing and disease. Finally, the third section surveys the technological innovations that allow the interrogation of this diversity and advancing our understanding of the integrated cardiovascular function and dysfunction.
figure legend This white paper discusses the cell diversity, co‐ordination and interaction patterns that are critical for robust cardiovascular function. We identify the major cell types and signals involved in cardiovascular function and emphasize the complexity at the subcellular, cellular and system levels that motivate both challenges and opportunities for researchers. 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This biannual meeting aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2022 Symposium was ‘Cell Diversity in the Cardiovascular System, cell‐autonomous and cell–cell signalling’. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies, and challenges in examining cell and signal diversity, co‐ordination and interrelationships involved in cardiovascular function. This paper originates from the topics of formal presentations and informal discussions from the Symposium, which aimed to develop a holistic view of how the multiple cell types in the cardiovascular system integrate to influence cardiovascular function, disease progression and therapeutic strategies. The first section describes the major cell types (e.g. cardiomyocytes, vascular smooth muscle and endothelial cells, fibroblasts, neurons, immune cells, etc.) and the signals involved in cardiovascular function. The second section emphasizes the complexity at the subcellular, cellular and system levels in the context of cardiovascular development, ageing and disease. Finally, the third section surveys the technological innovations that allow the interrogation of this diversity and advancing our understanding of the integrated cardiovascular function and dysfunction.
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| ispartof | The Journal of physiology, 2023-07, Vol.601 (13), p.2547-2592 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | animal models Arrhythmia Arrhythmias, Cardiac Cardiomyocytes Cardiovascular Diseases Cardiovascular system Endothelial Cells Fibroblasts Humans ion channels ion transporters Life Sciences Mathematical models modelling Myocytes, Cardiac omics signal transduction Smooth muscle |
| title | Diversity of cells and signals in the cardiovascular system |
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