Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress

Excessive reactive oxygen species production by mitochondria (mtROS) is a key contributor to age-related vascular endothelial dysfunction. We recently showed in a crossover design, placebo-controlled clinical trial in older adults that 6 wk of treatment with the mitochondria-targeted antioxidant (Mi...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2023-07, Vol.325 (1), p.H187-H194
Hauptverfasser:	Murray, Kevin O, Ludwig, Katelyn R, Darvish, Sanna, Coppock, McKinley E, Seals, Douglas R, Rossman, Matthew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antioxidants - therapeutic use Cross-Over Studies Endothelial Cells - metabolism Endothelium, Vascular - metabolism Female Humans Lipoproteins, LDL - metabolism Mitochondria - metabolism Nitric Oxide - metabolism Oxidative Stress Reactive Oxygen Species - metabolism Short Report Vascular Diseases - metabolism
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