scHi-CSim: a flexible simulator that generates high-fidelity single-cell Hi-C data for benchmarking

Single-cell Hi-C technology provides an unprecedented opportunity to reveal chromatin structure in individual cells. However, high sequencing cost impedes the generation of biological Hi-C data with high sequencing depths and multiple replicates for downstream analysis. Here, we developed a single-c...

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Veröffentlicht in:	Journal of molecular cell biology 2023-06, Vol.15 (1)
Hauptverfasser:	Fan, Shichen, Dang, Dachang, Ye, Yusen, Zhang, Shao-Wu, Gao, Lin, Zhang, Shihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Benchmarking Chromatin - genetics Chromosomes
Online-Zugang:	Volltext
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