Ethnic Issues and Disparities in Inflammatory Bowel Diseases: What Can We Learn from the Arab Population in Israel?
Inflammatory bowel diseases are increasing among different ethnic groups. We aimed to compare the clinical characteristics, complications, and outcomes among Arab and Jewish people sharing the same healthcare system. All patients older than 18 years with a diagnosis of Crohn's disease (CD) or u...
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| Veröffentlicht in: | Journal of personalized medicine 2023-06, Vol.13 (6), p.1008 |
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| creator | Abu-Freha, Naim Ealiwa, Nour AbuTailakh, Muhammad Abu-Abed, Muhammad Bader, Sarah Tabu, Rachel Schwartz, Doron |
| description | Inflammatory bowel diseases are increasing among different ethnic groups. We aimed to compare the clinical characteristics, complications, and outcomes among Arab and Jewish people sharing the same healthcare system. All patients older than 18 years with a diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) between the years 2000 and 2021 were included. Data regarding demographics, disease characteristics, extraintestinal manifestation, treatment, comorbidities, and mortality were retrieved. A total of 1263 (9.8%) Arab CD patients were compared with 11,625 Jewish CD patients, and 1461 (11.8%) Arab UC patients were compared to 10,920 Jewish patients. Arab CD patients were younger at diagnosis, 36.11 ± 16.7 compared to 39.98 ± 19.4 years,
< 0.001, 59.5% males compared to 48.7%,
< 0.001; in addition, Arab CD patients had a higher rate of anal fissure, perianal abscess, erythema nodosum, diabetes mellitus, obesity, liver cirrhosis, and male infertility. Arab CD patients were less frequently treated with azathioprine or mercaptopurine compared with Jewish patients. No significant difference was found in the rate of anti-TNF treatment, but a higher rate of steroids treatment was found. The all-cause mortality of CD patients was lower among Arab patients (8.4% vs. 10.2%,
= 0.039). Significant differences were found regarding disease characteristics, course, comorbidities, and treatment among Arab and Jewish patients with IBD. |
| doi_str_mv | 10.3390/jpm13061008 |
| format | Article |
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< 0.001, 59.5% males compared to 48.7%,
< 0.001; in addition, Arab CD patients had a higher rate of anal fissure, perianal abscess, erythema nodosum, diabetes mellitus, obesity, liver cirrhosis, and male infertility. Arab CD patients were less frequently treated with azathioprine or mercaptopurine compared with Jewish patients. No significant difference was found in the rate of anti-TNF treatment, but a higher rate of steroids treatment was found. The all-cause mortality of CD patients was lower among Arab patients (8.4% vs. 10.2%,
= 0.039). Significant differences were found regarding disease characteristics, course, comorbidities, and treatment among Arab and Jewish patients with IBD.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm13061008</identifier><identifier>PMID: 37373997</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>6-Mercaptopurine ; Arab people ; Azathioprine ; Cirrhosis ; Comorbidity ; Comparative analysis ; Crohn's disease ; Data collection ; Diabetes mellitus ; Diagnosis ; Emergency medical care ; Epidemiology ; Erythema ; Erythema nodosum ; Ethnicity ; Health aspects ; Health maintenance organizations ; HMOs ; Hospitalization ; Infertility ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Intestine ; Israel ; Laboratories ; Minority & ethnic groups ; Mortality ; Patients ; Population ; Precision medicine ; Steroid hormones ; Tumor necrosis factor ; Ulcerative colitis ; Variables</subject><ispartof>Journal of personalized medicine, 2023-06, Vol.13 (6), p.1008</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-c84531fc563f85535659bcefd36be91910e679dfcca8c8bb2a05b2d3a0e0e2f13</citedby><cites>FETCH-LOGICAL-c477t-c84531fc563f85535659bcefd36be91910e679dfcca8c8bb2a05b2d3a0e0e2f13</cites><orcidid>0009-0006-0790-6536 ; 0000-0002-4844-3308 ; 0000-0003-3770-0927</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301587/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301587/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37373997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abu-Freha, Naim</creatorcontrib><creatorcontrib>Ealiwa, Nour</creatorcontrib><creatorcontrib>AbuTailakh, Muhammad</creatorcontrib><creatorcontrib>Abu-Abed, Muhammad</creatorcontrib><creatorcontrib>Bader, Sarah</creatorcontrib><creatorcontrib>Tabu, Rachel</creatorcontrib><creatorcontrib>Schwartz, Doron</creatorcontrib><title>Ethnic Issues and Disparities in Inflammatory Bowel Diseases: What Can We Learn from the Arab Population in Israel?</title><title>Journal of personalized medicine</title><addtitle>J Pers Med</addtitle><description>Inflammatory bowel diseases are increasing among different ethnic groups. We aimed to compare the clinical characteristics, complications, and outcomes among Arab and Jewish people sharing the same healthcare system. All patients older than 18 years with a diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) between the years 2000 and 2021 were included. Data regarding demographics, disease characteristics, extraintestinal manifestation, treatment, comorbidities, and mortality were retrieved. A total of 1263 (9.8%) Arab CD patients were compared with 11,625 Jewish CD patients, and 1461 (11.8%) Arab UC patients were compared to 10,920 Jewish patients. Arab CD patients were younger at diagnosis, 36.11 ± 16.7 compared to 39.98 ± 19.4 years,
< 0.001, 59.5% males compared to 48.7%,
< 0.001; in addition, Arab CD patients had a higher rate of anal fissure, perianal abscess, erythema nodosum, diabetes mellitus, obesity, liver cirrhosis, and male infertility. Arab CD patients were less frequently treated with azathioprine or mercaptopurine compared with Jewish patients. No significant difference was found in the rate of anti-TNF treatment, but a higher rate of steroids treatment was found. The all-cause mortality of CD patients was lower among Arab patients (8.4% vs. 10.2%,
= 0.039). Significant differences were found regarding disease characteristics, course, comorbidities, and treatment among Arab and Jewish patients with IBD.</description><subject>6-Mercaptopurine</subject><subject>Arab people</subject><subject>Azathioprine</subject><subject>Cirrhosis</subject><subject>Comorbidity</subject><subject>Comparative analysis</subject><subject>Crohn's disease</subject><subject>Data collection</subject><subject>Diabetes mellitus</subject><subject>Diagnosis</subject><subject>Emergency medical care</subject><subject>Epidemiology</subject><subject>Erythema</subject><subject>Erythema nodosum</subject><subject>Ethnicity</subject><subject>Health aspects</subject><subject>Health maintenance organizations</subject><subject>HMOs</subject><subject>Hospitalization</subject><subject>Infertility</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Intestine</subject><subject>Israel</subject><subject>Laboratories</subject><subject>Minority & ethnic groups</subject><subject>Mortality</subject><subject>Patients</subject><subject>Population</subject><subject>Precision medicine</subject><subject>Steroid hormones</subject><subject>Tumor necrosis factor</subject><subject>Ulcerative colitis</subject><subject>Variables</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkkFv1DAQhSMEolXbE3dkiQsS2taO147DpVq2BVZaCQ6gHq2JM-56ldjBTlr139dLS9kiPAeP7W-eNU9TFG8YPeW8pmfboWecSkapelEclrQSs_m8lC_38oPiJKUtzUuJspT0dXHAqxx1XR0W6XLceGfIKqUJEwHfkguXBohudPnsPFl520HfwxjiHfkUbrHbEQgJ00dytYGRLMGTKyRrhOiJjaEn4wbJIkJDvodh6mB0wf-WShGwOz8uXlnoEp487kfFz8-XP5ZfZ-tvX1bLxXpm5lU1zoyaC86sEZJbJQQXUtSNQdty2WDNakZRVnVrjQFlVNOUQEVTthwoUiwt40fF-YPuMDU9tgb9GKHTQ3Q9xDsdwOnnL95t9HW40YxyyoSqssL7R4UYfmV_Rt27ZLDrwGOYki5V9l4KJmhG3_2DbsMUfe4vU2WtmJCU_6WuoUPtvA35Y7MT1YtKKK4ol3WmTv9D5WixdyZ4tC7fPyv48FBgYkgpon1qklG9mxO9NyeZfrvvyxP7Zyr4PZFXt0Q</recordid><startdate>20230617</startdate><enddate>20230617</enddate><creator>Abu-Freha, Naim</creator><creator>Ealiwa, Nour</creator><creator>AbuTailakh, Muhammad</creator><creator>Abu-Abed, Muhammad</creator><creator>Bader, Sarah</creator><creator>Tabu, Rachel</creator><creator>Schwartz, Doron</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0006-0790-6536</orcidid><orcidid>https://orcid.org/0000-0002-4844-3308</orcidid><orcidid>https://orcid.org/0000-0003-3770-0927</orcidid></search><sort><creationdate>20230617</creationdate><title>Ethnic Issues and Disparities in Inflammatory Bowel Diseases: What Can We Learn from the Arab Population in Israel?</title><author>Abu-Freha, Naim ; 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We aimed to compare the clinical characteristics, complications, and outcomes among Arab and Jewish people sharing the same healthcare system. All patients older than 18 years with a diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) between the years 2000 and 2021 were included. Data regarding demographics, disease characteristics, extraintestinal manifestation, treatment, comorbidities, and mortality were retrieved. A total of 1263 (9.8%) Arab CD patients were compared with 11,625 Jewish CD patients, and 1461 (11.8%) Arab UC patients were compared to 10,920 Jewish patients. Arab CD patients were younger at diagnosis, 36.11 ± 16.7 compared to 39.98 ± 19.4 years,
< 0.001, 59.5% males compared to 48.7%,
< 0.001; in addition, Arab CD patients had a higher rate of anal fissure, perianal abscess, erythema nodosum, diabetes mellitus, obesity, liver cirrhosis, and male infertility. Arab CD patients were less frequently treated with azathioprine or mercaptopurine compared with Jewish patients. No significant difference was found in the rate of anti-TNF treatment, but a higher rate of steroids treatment was found. The all-cause mortality of CD patients was lower among Arab patients (8.4% vs. 10.2%,
= 0.039). Significant differences were found regarding disease characteristics, course, comorbidities, and treatment among Arab and Jewish patients with IBD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37373997</pmid><doi>10.3390/jpm13061008</doi><orcidid>https://orcid.org/0009-0006-0790-6536</orcidid><orcidid>https://orcid.org/0000-0002-4844-3308</orcidid><orcidid>https://orcid.org/0000-0003-3770-0927</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | 6-Mercaptopurine Arab people Azathioprine Cirrhosis Comorbidity Comparative analysis Crohn's disease Data collection Diabetes mellitus Diagnosis Emergency medical care Epidemiology Erythema Erythema nodosum Ethnicity Health aspects Health maintenance organizations HMOs Hospitalization Infertility Inflammatory bowel disease Inflammatory bowel diseases Intestine Israel Laboratories Minority & ethnic groups Mortality Patients Population Precision medicine Steroid hormones Tumor necrosis factor Ulcerative colitis Variables |
| title | Ethnic Issues and Disparities in Inflammatory Bowel Diseases: What Can We Learn from the Arab Population in Israel? |
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