Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1

Sphingosine 1-phosphate receptor 1 (S1PR1) is a G protein–coupled receptor essential for vascular development and postnatal vascular homeostasis. When exposed to sphingosine 1-phosphate (S1P) in the blood of ∼1 μM, S1PR1 in endothelial cells retains cell-surface localization, while lymphocyte S1PR1...

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Veröffentlicht in:	The Journal of biological chemistry 2023-07, Vol.299 (7), p.104851-104851, Article 104851
Hauptverfasser:	Zhao, Xian, Kiyozuka, Keisuke, Konishi, Akimitsu, Kawabata-Iwakawa, Reika, Minamishima, Yoji Andrew, Obinata, Hideru
Format:	Artikel
Sprache:	eng
Schlagworte:	cell migration endothelial cell Endothelial Cells - metabolism filamin Filamins - genetics Filamins - metabolism G protein–coupled receptor (GPCR) Lysophospholipids - metabolism Proteomics proximity labeling proteomics receptor internalization Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism sphingolipid Sphingosine - metabolism sphingosine 1-phosphate (S1P) Sphingosine-1-Phosphate Receptors - metabolism
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