Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages
Diabetes mellitus (DM) is a metabolic disease characterized by a high blood sugar level that can cause severe complications to the organism or even death when not treated. However, certain dietary habits and foods may have beneficial effects on this condition. A polyphenolic-rich extract (containing...
Gespeichert in:
| Veröffentlicht in: | Journal of physiology and biochemistry 2023-05, Vol.79 (2), p.427-440 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 440 |
|---|---|
| container_issue | 2 |
| container_start_page | 427 |
| container_title | Journal of physiology and biochemistry |
| container_volume | 79 |
| creator | Núñez, Sonia Moliner, Cristina Valero, Marta Sofía Mustafa, Ahmed M. Maggi, Filippo Gómez-Rincón, Carlota López, Víctor |
| description | Diabetes mellitus (DM) is a metabolic disease characterized by a high blood sugar level that can cause severe complications to the organism or even death when not treated. However, certain dietary habits and foods may have beneficial effects on this condition. A polyphenolic-rich extract (containing hyperoside, isoquercitrin, quercetin, ellagic acid, and vanillic acid) of
Tageres erecta
L. (
T. erecta
) was obtained from yellow and orange flowers using an ethanolic Soxhlet extraction. These extracts were screened for antidiabetic and anti-obesity properties using in vitro and in vivo procedures. The capacity to inhibit the enzymes lipase and α-glucosidase, as well as the inhibition of advance glycation end-products (AGEs) was tested in vitro.
Caenorhabditis elegans (C. elegans)
was used as an obesity in vivo model to assess extracts effects on fat accumulation using the wild-type strain N2 and a mutant with no N3 fatty acid desaturase activity BX24. Extracts from both cultivars (yellow and orange)
T. erecta
presented in vitro inhibitory activity against the enzymes lipase and α-glucosidase, showing lower IC
50
values than acarbose (control). They also showed important activity in preventing AGEs formation. The polyphenol-rich matrices reduced the fat content of obese worms in the wild-type strain (N2) down to levels of untreated
C. elegans
, with no significant differences found between negative control (100% reduction) and both tested samples (
p
|
| doi_str_mv | 10.1007/s13105-023-00953-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10300173</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A754967804</galeid><sourcerecordid>A754967804</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-abfa7b28fb6462cc39cfd6507381af7b6b66b6675b55a8c8e577a3a7d63d46903</originalsourceid><addsrcrecordid>eNp9kt-K1DAUxoso7rr6Al5IwBtvOiZN07RXMgz-gwFv1uuQpiedLG1Sk4w6r-LTemZnHV0RSUPKOd_3g5N8RfGc0RWjVL5OjDMqSlrxktJO8FI8KC5ZK2XZSiEe4j_jbSlF3V4UT1K6obSuWEUfFxe86Romq_qy-LH22Q1O95CdIdoPuLMrQw_J5QNZYlggZgeJBEs0WcJ0WHbgw1RGZ3bETuEbRALfc9QmExvDTK71CBkNEMFkTbarW6zLWLEWS4jyZKMREne6H1x22Jlg1D4RqzNJOUREpKfFI6unBM_uzqvi87u315sP5fbT-4-b9bY0oq5yqXurZV-1tm_qpjKGd8YOjaCSt0xb2Td9c_yk6IXQrWlBSKm5lkPDh7rpKL8q3py4y76fYTDgcZhJLdHNOh5U0E7d73i3U2P4qhjllDLJkfDqjhDDlz2krGaXDEyT9hD2SVWyY1xyKjuUvvxLehP20eN8qmo5AusOX-2sGvUEynkbjvd7hKo1vmfXyJbWqFr9Q4VrgNmZ4ME6rN8zVCeDiSGlCPY8JKPqGCl1ipTCSKnbSCmBphd_Xs_Z8itDKOAnQcKWHyH-Huk_2J85tNi8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2830304911</pqid></control><display><type>article</type><title>Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Núñez, Sonia ; Moliner, Cristina ; Valero, Marta Sofía ; Mustafa, Ahmed M. ; Maggi, Filippo ; Gómez-Rincón, Carlota ; López, Víctor</creator><creatorcontrib>Núñez, Sonia ; Moliner, Cristina ; Valero, Marta Sofía ; Mustafa, Ahmed M. ; Maggi, Filippo ; Gómez-Rincón, Carlota ; López, Víctor</creatorcontrib><description>Diabetes mellitus (DM) is a metabolic disease characterized by a high blood sugar level that can cause severe complications to the organism or even death when not treated. However, certain dietary habits and foods may have beneficial effects on this condition. A polyphenolic-rich extract (containing hyperoside, isoquercitrin, quercetin, ellagic acid, and vanillic acid) of
Tageres erecta
L. (
T. erecta
) was obtained from yellow and orange flowers using an ethanolic Soxhlet extraction. These extracts were screened for antidiabetic and anti-obesity properties using in vitro and in vivo procedures. The capacity to inhibit the enzymes lipase and α-glucosidase, as well as the inhibition of advance glycation end-products (AGEs) was tested in vitro.
Caenorhabditis elegans (C. elegans)
was used as an obesity in vivo model to assess extracts effects on fat accumulation using the wild-type strain N2 and a mutant with no N3 fatty acid desaturase activity BX24. Extracts from both cultivars (yellow and orange)
T. erecta
presented in vitro inhibitory activity against the enzymes lipase and α-glucosidase, showing lower IC
50
values than acarbose (control). They also showed important activity in preventing AGEs formation. The polyphenol-rich matrices reduced the fat content of obese worms in the wild-type strain (N2) down to levels of untreated
C. elegans
, with no significant differences found between negative control (100% reduction) and both tested samples (
p
< 0.05). Meanwhile, the fat reduction was considerably lower in the BX24 mutants (fat-1(wa-9)), suggesting that N3 fatty acid desaturase activity could be partially involved in the
T. erecta
flower effect. Our findings suggested that polyphenols from
T. erecta
can be considered candidate bioactive compounds in the prevention and improvement of metabolic chronic diseases such as obesity and diabetes.</description><identifier>ISSN: 1138-7548</identifier><identifier>EISSN: 1877-8755</identifier><identifier>DOI: 10.1007/s13105-023-00953-5</identifier><identifier>PMID: 36961724</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acarbose ; Advanced glycosylation end products ; alpha-Glucosidases - metabolism ; alpha-Glucosidases - pharmacology ; Analysis ; Animal Physiology ; Animals ; Bioactive compounds ; Biomedical and Life Sciences ; Biomedicine ; Blood sugar ; Caenorhabditis elegans ; Caenorhabditis elegans - metabolism ; Chronic diseases ; Cultivars ; Desaturase ; Diabetes ; Diabetes mellitus ; Ellagic acid ; Enzymes ; Fatty Acid Desaturases - metabolism ; Fatty Acid Desaturases - pharmacology ; Fatty acids ; Flowers ; Glucosidase ; Glycation End Products, Advanced - metabolism ; Glycation End Products, Advanced - pharmacology ; Human Physiology ; Hyperglycemia ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Lipase ; Lipase - metabolism ; Metabolic disorders ; Metabolism ; Mutants ; Nematodes ; Obesity ; Obesity - drug therapy ; Original ; Original Article ; Plant Extracts - metabolism ; Plant Extracts - pharmacology ; Polyphenols ; Polyphenols - metabolism ; Polyphenols - pharmacology ; Quercetin ; Reduction ; Tagetes ; Type 2 diabetes ; Vanillic acid ; α-Glucosidase</subject><ispartof>Journal of physiology and biochemistry, 2023-05, Vol.79 (2), p.427-440</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-abfa7b28fb6462cc39cfd6507381af7b6b66b6675b55a8c8e577a3a7d63d46903</citedby><cites>FETCH-LOGICAL-c542t-abfa7b28fb6462cc39cfd6507381af7b6b66b6675b55a8c8e577a3a7d63d46903</cites><orcidid>0000-0003-3982-2282</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13105-023-00953-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13105-023-00953-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36961724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Núñez, Sonia</creatorcontrib><creatorcontrib>Moliner, Cristina</creatorcontrib><creatorcontrib>Valero, Marta Sofía</creatorcontrib><creatorcontrib>Mustafa, Ahmed M.</creatorcontrib><creatorcontrib>Maggi, Filippo</creatorcontrib><creatorcontrib>Gómez-Rincón, Carlota</creatorcontrib><creatorcontrib>López, Víctor</creatorcontrib><title>Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages</title><title>Journal of physiology and biochemistry</title><addtitle>J Physiol Biochem</addtitle><addtitle>J Physiol Biochem</addtitle><description>Diabetes mellitus (DM) is a metabolic disease characterized by a high blood sugar level that can cause severe complications to the organism or even death when not treated. However, certain dietary habits and foods may have beneficial effects on this condition. A polyphenolic-rich extract (containing hyperoside, isoquercitrin, quercetin, ellagic acid, and vanillic acid) of
Tageres erecta
L. (
T. erecta
) was obtained from yellow and orange flowers using an ethanolic Soxhlet extraction. These extracts were screened for antidiabetic and anti-obesity properties using in vitro and in vivo procedures. The capacity to inhibit the enzymes lipase and α-glucosidase, as well as the inhibition of advance glycation end-products (AGEs) was tested in vitro.
Caenorhabditis elegans (C. elegans)
was used as an obesity in vivo model to assess extracts effects on fat accumulation using the wild-type strain N2 and a mutant with no N3 fatty acid desaturase activity BX24. Extracts from both cultivars (yellow and orange)
T. erecta
presented in vitro inhibitory activity against the enzymes lipase and α-glucosidase, showing lower IC
50
values than acarbose (control). They also showed important activity in preventing AGEs formation. The polyphenol-rich matrices reduced the fat content of obese worms in the wild-type strain (N2) down to levels of untreated
C. elegans
, with no significant differences found between negative control (100% reduction) and both tested samples (
p
< 0.05). Meanwhile, the fat reduction was considerably lower in the BX24 mutants (fat-1(wa-9)), suggesting that N3 fatty acid desaturase activity could be partially involved in the
T. erecta
flower effect. Our findings suggested that polyphenols from
T. erecta
can be considered candidate bioactive compounds in the prevention and improvement of metabolic chronic diseases such as obesity and diabetes.</description><subject>Acarbose</subject><subject>Advanced glycosylation end products</subject><subject>alpha-Glucosidases - metabolism</subject><subject>alpha-Glucosidases - pharmacology</subject><subject>Analysis</subject><subject>Animal Physiology</subject><subject>Animals</subject><subject>Bioactive compounds</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood sugar</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - metabolism</subject><subject>Chronic diseases</subject><subject>Cultivars</subject><subject>Desaturase</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Ellagic acid</subject><subject>Enzymes</subject><subject>Fatty Acid Desaturases - metabolism</subject><subject>Fatty Acid Desaturases - pharmacology</subject><subject>Fatty acids</subject><subject>Flowers</subject><subject>Glucosidase</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Glycation End Products, Advanced - pharmacology</subject><subject>Human Physiology</subject><subject>Hyperglycemia</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Lipase</subject><subject>Lipase - metabolism</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Mutants</subject><subject>Nematodes</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Original</subject><subject>Original Article</subject><subject>Plant Extracts - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols</subject><subject>Polyphenols - metabolism</subject><subject>Polyphenols - pharmacology</subject><subject>Quercetin</subject><subject>Reduction</subject><subject>Tagetes</subject><subject>Type 2 diabetes</subject><subject>Vanillic acid</subject><subject>α-Glucosidase</subject><issn>1138-7548</issn><issn>1877-8755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kt-K1DAUxoso7rr6Al5IwBtvOiZN07RXMgz-gwFv1uuQpiedLG1Sk4w6r-LTemZnHV0RSUPKOd_3g5N8RfGc0RWjVL5OjDMqSlrxktJO8FI8KC5ZK2XZSiEe4j_jbSlF3V4UT1K6obSuWEUfFxe86Romq_qy-LH22Q1O95CdIdoPuLMrQw_J5QNZYlggZgeJBEs0WcJ0WHbgw1RGZ3bETuEbRALfc9QmExvDTK71CBkNEMFkTbarW6zLWLEWS4jyZKMREne6H1x22Jlg1D4RqzNJOUREpKfFI6unBM_uzqvi87u315sP5fbT-4-b9bY0oq5yqXurZV-1tm_qpjKGd8YOjaCSt0xb2Td9c_yk6IXQrWlBSKm5lkPDh7rpKL8q3py4y76fYTDgcZhJLdHNOh5U0E7d73i3U2P4qhjllDLJkfDqjhDDlz2krGaXDEyT9hD2SVWyY1xyKjuUvvxLehP20eN8qmo5AusOX-2sGvUEynkbjvd7hKo1vmfXyJbWqFr9Q4VrgNmZ4ME6rN8zVCeDiSGlCPY8JKPqGCl1ipTCSKnbSCmBphd_Xs_Z8itDKOAnQcKWHyH-Huk_2J85tNi8</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Núñez, Sonia</creator><creator>Moliner, Cristina</creator><creator>Valero, Marta Sofía</creator><creator>Mustafa, Ahmed M.</creator><creator>Maggi, Filippo</creator><creator>Gómez-Rincón, Carlota</creator><creator>López, Víctor</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3982-2282</orcidid></search><sort><creationdate>20230501</creationdate><title>Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages</title><author>Núñez, Sonia ; Moliner, Cristina ; Valero, Marta Sofía ; Mustafa, Ahmed M. ; Maggi, Filippo ; Gómez-Rincón, Carlota ; López, Víctor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-abfa7b28fb6462cc39cfd6507381af7b6b66b6675b55a8c8e577a3a7d63d46903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acarbose</topic><topic>Advanced glycosylation end products</topic><topic>alpha-Glucosidases - metabolism</topic><topic>alpha-Glucosidases - pharmacology</topic><topic>Analysis</topic><topic>Animal Physiology</topic><topic>Animals</topic><topic>Bioactive compounds</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood sugar</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - metabolism</topic><topic>Chronic diseases</topic><topic>Cultivars</topic><topic>Desaturase</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Ellagic acid</topic><topic>Enzymes</topic><topic>Fatty Acid Desaturases - metabolism</topic><topic>Fatty Acid Desaturases - pharmacology</topic><topic>Fatty acids</topic><topic>Flowers</topic><topic>Glucosidase</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>Glycation End Products, Advanced - pharmacology</topic><topic>Human Physiology</topic><topic>Hyperglycemia</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Lipase</topic><topic>Lipase - metabolism</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Mutants</topic><topic>Nematodes</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Original</topic><topic>Original Article</topic><topic>Plant Extracts - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Polyphenols</topic><topic>Polyphenols - metabolism</topic><topic>Polyphenols - pharmacology</topic><topic>Quercetin</topic><topic>Reduction</topic><topic>Tagetes</topic><topic>Type 2 diabetes</topic><topic>Vanillic acid</topic><topic>α-Glucosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Núñez, Sonia</creatorcontrib><creatorcontrib>Moliner, Cristina</creatorcontrib><creatorcontrib>Valero, Marta Sofía</creatorcontrib><creatorcontrib>Mustafa, Ahmed M.</creatorcontrib><creatorcontrib>Maggi, Filippo</creatorcontrib><creatorcontrib>Gómez-Rincón, Carlota</creatorcontrib><creatorcontrib>López, Víctor</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Núñez, Sonia</au><au>Moliner, Cristina</au><au>Valero, Marta Sofía</au><au>Mustafa, Ahmed M.</au><au>Maggi, Filippo</au><au>Gómez-Rincón, Carlota</au><au>López, Víctor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages</atitle><jtitle>Journal of physiology and biochemistry</jtitle><stitle>J Physiol Biochem</stitle><addtitle>J Physiol Biochem</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>79</volume><issue>2</issue><spage>427</spage><epage>440</epage><pages>427-440</pages><issn>1138-7548</issn><eissn>1877-8755</eissn><abstract>Diabetes mellitus (DM) is a metabolic disease characterized by a high blood sugar level that can cause severe complications to the organism or even death when not treated. However, certain dietary habits and foods may have beneficial effects on this condition. A polyphenolic-rich extract (containing hyperoside, isoquercitrin, quercetin, ellagic acid, and vanillic acid) of
Tageres erecta
L. (
T. erecta
) was obtained from yellow and orange flowers using an ethanolic Soxhlet extraction. These extracts were screened for antidiabetic and anti-obesity properties using in vitro and in vivo procedures. The capacity to inhibit the enzymes lipase and α-glucosidase, as well as the inhibition of advance glycation end-products (AGEs) was tested in vitro.
Caenorhabditis elegans (C. elegans)
was used as an obesity in vivo model to assess extracts effects on fat accumulation using the wild-type strain N2 and a mutant with no N3 fatty acid desaturase activity BX24. Extracts from both cultivars (yellow and orange)
T. erecta
presented in vitro inhibitory activity against the enzymes lipase and α-glucosidase, showing lower IC
50
values than acarbose (control). They also showed important activity in preventing AGEs formation. The polyphenol-rich matrices reduced the fat content of obese worms in the wild-type strain (N2) down to levels of untreated
C. elegans
, with no significant differences found between negative control (100% reduction) and both tested samples (
p
< 0.05). Meanwhile, the fat reduction was considerably lower in the BX24 mutants (fat-1(wa-9)), suggesting that N3 fatty acid desaturase activity could be partially involved in the
T. erecta
flower effect. Our findings suggested that polyphenols from
T. erecta
can be considered candidate bioactive compounds in the prevention and improvement of metabolic chronic diseases such as obesity and diabetes.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>36961724</pmid><doi>10.1007/s13105-023-00953-5</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-3982-2282</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1138-7548 |
| ispartof | Journal of physiology and biochemistry, 2023-05, Vol.79 (2), p.427-440 |
| issn | 1138-7548 1877-8755 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10300173 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Acarbose Advanced glycosylation end products alpha-Glucosidases - metabolism alpha-Glucosidases - pharmacology Analysis Animal Physiology Animals Bioactive compounds Biomedical and Life Sciences Biomedicine Blood sugar Caenorhabditis elegans Caenorhabditis elegans - metabolism Chronic diseases Cultivars Desaturase Diabetes Diabetes mellitus Ellagic acid Enzymes Fatty Acid Desaturases - metabolism Fatty Acid Desaturases - pharmacology Fatty acids Flowers Glucosidase Glycation End Products, Advanced - metabolism Glycation End Products, Advanced - pharmacology Human Physiology Hyperglycemia Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Lipase Lipase - metabolism Metabolic disorders Metabolism Mutants Nematodes Obesity Obesity - drug therapy Original Original Article Plant Extracts - metabolism Plant Extracts - pharmacology Polyphenols Polyphenols - metabolism Polyphenols - pharmacology Quercetin Reduction Tagetes Type 2 diabetes Vanillic acid α-Glucosidase |
| title | Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T01%3A21%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antidiabetic%20and%20anti-obesity%20properties%20of%20a%20polyphenol-rich%20flower%20extract%20from%20Tagetes%20erecta%20L.%20and%20its%20effects%20on%20Caenorhabditis%20elegans%20fat%20storages&rft.jtitle=Journal%20of%20physiology%20and%20biochemistry&rft.au=N%C3%BA%C3%B1ez,%20Sonia&rft.date=2023-05-01&rft.volume=79&rft.issue=2&rft.spage=427&rft.epage=440&rft.pages=427-440&rft.issn=1138-7548&rft.eissn=1877-8755&rft_id=info:doi/10.1007/s13105-023-00953-5&rft_dat=%3Cgale_pubme%3EA754967804%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2830304911&rft_id=info:pmid/36961724&rft_galeid=A754967804&rfr_iscdi=true |