Behavior of host-cell-protein-rich aggregates in antibody capture and polishing chromatography

•HCP persistence is partially mediated by aggregates in mAb solutions.•Aggregates compete with mAb to adsorb specifically in protein A chromatography.•Aggregates may co-elute with the mAb in protein A chromatography.•Aggregate and HCP clearance may be correlated in flow-through AEX polishing.•Relati...

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