Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia-A Systematic Review
The aim of this review is to appraise the data from available randomized clinical trials (RCT) regarding the possible combinations of neuroleptic and non-antipsychotic treatment which could enhance antipsychotic therapy efficacy whilst simultaneously addressing somatic symptoms in individuals with s...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2023-06, Vol.12 (12), p.4012 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | 4012 |
| container_title | Journal of clinical medicine |
| container_volume | 12 |
| creator | Dróżdż, Wiktor Wiciński, Michał Szota, Anna Maria Szambelan, Monika Radajewska, Izabela Popławski, Igor Wojciechowski, Paweł |
| description | The aim of this review is to appraise the data from available randomized clinical trials (RCT) regarding the possible combinations of neuroleptic and non-antipsychotic treatment which could enhance antipsychotic therapy efficacy whilst simultaneously addressing somatic symptoms in individuals with schizophrenia. A systematic search of the PubMed database up to February 2022 was conducted. Inclusion criteria: randomized controlled trials using augmentation therapy in chronic schizophrenia in adults, written in English, and only studies with psychometric assessments of schizophrenia were incorporated. Exclusion criteria: non-clinical, first episode of schizophrenia, patients on medication other than antipsychotics augmented, and not adjunctive therapy. Overall, 37 studies of 1931 patients with schizophrenia who received a combination of antipsychotic medication with other drugs were selected. A statistically significant reduction of negative and positive symptoms of schizophrenia, measured with the PANSS scale, when using a combination of antipsychotic treatment along with aspirin, simvastatin, N-acetylcysteine, or pioglitazone was found. A combination of antipsychotic medication with aspirin, simvastatin, N-acetylcysteine, or pioglitazone seems to be effective in the reduction of symptoms of schizophrenia in adults, but long-term studies are required to confirm this effect. |
| doi_str_mv | 10.3390/jcm12124012 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10299654</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A758335616</galeid><sourcerecordid>A758335616</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-3a6fee82670eeabe70a3ea42722ccff0aedb103154f09b57a8f8ef366aada3423</originalsourceid><addsrcrecordid>eNptkstrGzEQxkVpaEKaU-9F0EshbKrXvk7FmL4g0FC7ZzErj2yZXcmVdtOkf31lnKZOqeagQfObT8zwEfKKsyspW_ZuawYuuFCMi2fkTLC6Lphs5POj_JRcpLRl-TSNErx-QU5lvQ-mzoibTesB_QijC54uNxhh5zBRSHQZEcZ9LVEbIp0HvHNpdH5NF2HIvKE3MXQ9Dok6Txdm436F3Said1DM6OI-jXjAvuGtw58vyYmFPuHFw31Ovn_8sJx_Lq6_fvoyn10XRslyLCRUFrERVc0QocOagURQohbCGGsZ4KrjTPJSWdZ2ZQ2NbdDKqgJYgVRCnpP3B93d1A24MnmACL3eRTdAvNcBnH5a8W6j1-FWcybatipVVnj7oBDDjwnTqAeXDPY9eAxT0qKRrKpUKXlG3_yDbsMUfZ4vU6JteN4z-0utoUftvA35Y7MX1bO6bKQsK15l6uo_VI4VDs4Ej9bl9ycNl4cGE0NKEe3jkJzpvTv0kTsy_fp4L4_sHy_I35VXtdQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2829813730</pqid></control><display><type>article</type><title>Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia-A Systematic Review</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Dróżdż, Wiktor ; Wiciński, Michał ; Szota, Anna Maria ; Szambelan, Monika ; Radajewska, Izabela ; Popławski, Igor ; Wojciechowski, Paweł</creator><creatorcontrib>Dróżdż, Wiktor ; Wiciński, Michał ; Szota, Anna Maria ; Szambelan, Monika ; Radajewska, Izabela ; Popławski, Igor ; Wojciechowski, Paweł</creatorcontrib><description>The aim of this review is to appraise the data from available randomized clinical trials (RCT) regarding the possible combinations of neuroleptic and non-antipsychotic treatment which could enhance antipsychotic therapy efficacy whilst simultaneously addressing somatic symptoms in individuals with schizophrenia. A systematic search of the PubMed database up to February 2022 was conducted. Inclusion criteria: randomized controlled trials using augmentation therapy in chronic schizophrenia in adults, written in English, and only studies with psychometric assessments of schizophrenia were incorporated. Exclusion criteria: non-clinical, first episode of schizophrenia, patients on medication other than antipsychotics augmented, and not adjunctive therapy. Overall, 37 studies of 1931 patients with schizophrenia who received a combination of antipsychotic medication with other drugs were selected. A statistically significant reduction of negative and positive symptoms of schizophrenia, measured with the PANSS scale, when using a combination of antipsychotic treatment along with aspirin, simvastatin, N-acetylcysteine, or pioglitazone was found. A combination of antipsychotic medication with aspirin, simvastatin, N-acetylcysteine, or pioglitazone seems to be effective in the reduction of symptoms of schizophrenia in adults, but long-term studies are required to confirm this effect.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12124012</identifier><identifier>PMID: 37373704</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antipsychotics ; Bias ; Care and treatment ; Chronic obstructive pulmonary disease ; Clinical medicine ; Clinical trials ; Comorbidity ; Diagnosis ; Drug resistance ; Intervention ; Metabolic syndrome ; Psychotropic drugs ; Public health ; Registration ; Risk factors ; Schizophrenia ; Systematic Review</subject><ispartof>Journal of clinical medicine, 2023-06, Vol.12 (12), p.4012</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c435t-3a6fee82670eeabe70a3ea42722ccff0aedb103154f09b57a8f8ef366aada3423</cites><orcidid>0000-0002-9184-342X ; 0000-0001-7880-287X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299654/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299654/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37373704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dróżdż, Wiktor</creatorcontrib><creatorcontrib>Wiciński, Michał</creatorcontrib><creatorcontrib>Szota, Anna Maria</creatorcontrib><creatorcontrib>Szambelan, Monika</creatorcontrib><creatorcontrib>Radajewska, Izabela</creatorcontrib><creatorcontrib>Popławski, Igor</creatorcontrib><creatorcontrib>Wojciechowski, Paweł</creatorcontrib><title>Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia-A Systematic Review</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>The aim of this review is to appraise the data from available randomized clinical trials (RCT) regarding the possible combinations of neuroleptic and non-antipsychotic treatment which could enhance antipsychotic therapy efficacy whilst simultaneously addressing somatic symptoms in individuals with schizophrenia. A systematic search of the PubMed database up to February 2022 was conducted. Inclusion criteria: randomized controlled trials using augmentation therapy in chronic schizophrenia in adults, written in English, and only studies with psychometric assessments of schizophrenia were incorporated. Exclusion criteria: non-clinical, first episode of schizophrenia, patients on medication other than antipsychotics augmented, and not adjunctive therapy. Overall, 37 studies of 1931 patients with schizophrenia who received a combination of antipsychotic medication with other drugs were selected. A statistically significant reduction of negative and positive symptoms of schizophrenia, measured with the PANSS scale, when using a combination of antipsychotic treatment along with aspirin, simvastatin, N-acetylcysteine, or pioglitazone was found. A combination of antipsychotic medication with aspirin, simvastatin, N-acetylcysteine, or pioglitazone seems to be effective in the reduction of symptoms of schizophrenia in adults, but long-term studies are required to confirm this effect.</description><subject>Antipsychotics</subject><subject>Bias</subject><subject>Care and treatment</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Comorbidity</subject><subject>Diagnosis</subject><subject>Drug resistance</subject><subject>Intervention</subject><subject>Metabolic syndrome</subject><subject>Psychotropic drugs</subject><subject>Public health</subject><subject>Registration</subject><subject>Risk factors</subject><subject>Schizophrenia</subject><subject>Systematic Review</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkstrGzEQxkVpaEKaU-9F0EshbKrXvk7FmL4g0FC7ZzErj2yZXcmVdtOkf31lnKZOqeagQfObT8zwEfKKsyspW_ZuawYuuFCMi2fkTLC6Lphs5POj_JRcpLRl-TSNErx-QU5lvQ-mzoibTesB_QijC54uNxhh5zBRSHQZEcZ9LVEbIp0HvHNpdH5NF2HIvKE3MXQ9Dok6Txdm436F3Said1DM6OI-jXjAvuGtw58vyYmFPuHFw31Ovn_8sJx_Lq6_fvoyn10XRslyLCRUFrERVc0QocOagURQohbCGGsZ4KrjTPJSWdZ2ZQ2NbdDKqgJYgVRCnpP3B93d1A24MnmACL3eRTdAvNcBnH5a8W6j1-FWcybatipVVnj7oBDDjwnTqAeXDPY9eAxT0qKRrKpUKXlG3_yDbsMUfZ4vU6JteN4z-0utoUftvA35Y7MX1bO6bKQsK15l6uo_VI4VDs4Ej9bl9ycNl4cGE0NKEe3jkJzpvTv0kTsy_fp4L4_sHy_I35VXtdQ</recordid><startdate>20230612</startdate><enddate>20230612</enddate><creator>Dróżdż, Wiktor</creator><creator>Wiciński, Michał</creator><creator>Szota, Anna Maria</creator><creator>Szambelan, Monika</creator><creator>Radajewska, Izabela</creator><creator>Popławski, Igor</creator><creator>Wojciechowski, Paweł</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9184-342X</orcidid><orcidid>https://orcid.org/0000-0001-7880-287X</orcidid></search><sort><creationdate>20230612</creationdate><title>Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia-A Systematic Review</title><author>Dróżdż, Wiktor ; Wiciński, Michał ; Szota, Anna Maria ; Szambelan, Monika ; Radajewska, Izabela ; Popławski, Igor ; Wojciechowski, Paweł</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-3a6fee82670eeabe70a3ea42722ccff0aedb103154f09b57a8f8ef366aada3423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antipsychotics</topic><topic>Bias</topic><topic>Care and treatment</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical medicine</topic><topic>Clinical trials</topic><topic>Comorbidity</topic><topic>Diagnosis</topic><topic>Drug resistance</topic><topic>Intervention</topic><topic>Metabolic syndrome</topic><topic>Psychotropic drugs</topic><topic>Public health</topic><topic>Registration</topic><topic>Risk factors</topic><topic>Schizophrenia</topic><topic>Systematic Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dróżdż, Wiktor</creatorcontrib><creatorcontrib>Wiciński, Michał</creatorcontrib><creatorcontrib>Szota, Anna Maria</creatorcontrib><creatorcontrib>Szambelan, Monika</creatorcontrib><creatorcontrib>Radajewska, Izabela</creatorcontrib><creatorcontrib>Popławski, Igor</creatorcontrib><creatorcontrib>Wojciechowski, Paweł</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dróżdż, Wiktor</au><au>Wiciński, Michał</au><au>Szota, Anna Maria</au><au>Szambelan, Monika</au><au>Radajewska, Izabela</au><au>Popławski, Igor</au><au>Wojciechowski, Paweł</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia-A Systematic Review</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2023-06-12</date><risdate>2023</risdate><volume>12</volume><issue>12</issue><spage>4012</spage><pages>4012-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>The aim of this review is to appraise the data from available randomized clinical trials (RCT) regarding the possible combinations of neuroleptic and non-antipsychotic treatment which could enhance antipsychotic therapy efficacy whilst simultaneously addressing somatic symptoms in individuals with schizophrenia. A systematic search of the PubMed database up to February 2022 was conducted. Inclusion criteria: randomized controlled trials using augmentation therapy in chronic schizophrenia in adults, written in English, and only studies with psychometric assessments of schizophrenia were incorporated. Exclusion criteria: non-clinical, first episode of schizophrenia, patients on medication other than antipsychotics augmented, and not adjunctive therapy. Overall, 37 studies of 1931 patients with schizophrenia who received a combination of antipsychotic medication with other drugs were selected. A statistically significant reduction of negative and positive symptoms of schizophrenia, measured with the PANSS scale, when using a combination of antipsychotic treatment along with aspirin, simvastatin, N-acetylcysteine, or pioglitazone was found. A combination of antipsychotic medication with aspirin, simvastatin, N-acetylcysteine, or pioglitazone seems to be effective in the reduction of symptoms of schizophrenia in adults, but long-term studies are required to confirm this effect.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37373704</pmid><doi>10.3390/jcm12124012</doi><orcidid>https://orcid.org/0000-0002-9184-342X</orcidid><orcidid>https://orcid.org/0000-0001-7880-287X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2023-06, Vol.12 (12), p.4012 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10299654 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antipsychotics Bias Care and treatment Chronic obstructive pulmonary disease Clinical medicine Clinical trials Comorbidity Diagnosis Drug resistance Intervention Metabolic syndrome Psychotropic drugs Public health Registration Risk factors Schizophrenia Systematic Review |
| title | Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia-A Systematic Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T01%3A23%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Augmentation%20Therapies%20as%20Treatments%20for%20Coexisting%20Somatic%20Problems%20in%20Schizophrenia-A%20Systematic%20Review&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Dr%C3%B3%C5%BCd%C5%BC,%20Wiktor&rft.date=2023-06-12&rft.volume=12&rft.issue=12&rft.spage=4012&rft.pages=4012-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm12124012&rft_dat=%3Cgale_pubme%3EA758335616%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2829813730&rft_id=info:pmid/37373704&rft_galeid=A758335616&rfr_iscdi=true |