Relationship between Serum Cortisol, Dehydroepiandrosterone Sulfate (DHEAS) Levels, and Natural Killer Cell Activity: A Cross-Sectional Study
The adrenal steroid hormones, cortisol and dehydroepiandrosterone sulfate (DHEAS), are associated with the immune system in opposite actions. This study aimed to investigate the relationship between cortisol and DHEAS serum concentrations, their ratio (CDR), and natural killer cell activity (NKA). T...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2023-06, Vol.12 (12), p.4027 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | 4027 |
| container_title | Journal of clinical medicine |
| container_volume | 12 |
| creator | Suh, Eunkyung Cho, A-Ra Haam, Ji-Hee Gil, Minchan Lee, Yun-Kyong Kim, Young-Sang |
| description | The adrenal steroid hormones, cortisol and dehydroepiandrosterone sulfate (DHEAS), are associated with the immune system in opposite actions. This study aimed to investigate the relationship between cortisol and DHEAS serum concentrations, their ratio (CDR), and natural killer cell activity (NKA). This cross-sectional study included 2275 subjects without current infection or inflammation in the final analyses. NKA was estimated by measuring the amount of interferon-gamma (IFN-γ) released by activated natural killer cells; low NKA was defined as IFN-γ level < 500 pg/mL. Cortisol, DHEAS levels, and CDRs were categorized by quartiles in men, premenopausal women, and postmenopausal women. Compared with the lowest quartile as reference, the adjusted odd ratios (ORs) and 95% confidence intervals (CIs) for low NKA of the highest cortisol and CDR group were 1.66 (1.09-2.51) and 1.68 (1.11-2.55) in men, 1.58 (1.07-2.33) and 2.33 (1.58-3.46) in premenopausal women, and 2.23 (1.28-3.87) and 1.85 (1.07-3.21) in postmenopausal women. Only in premenopausal women, the highest DHEAS group showed significantly lower risk of low NKA (OR: 0.51, 95% CI: 0.35-0.76). HPA axis activation indicated as high cortisol level, CDR was significantly associated with low NKA, while high DHEAS levels were inversely associated with low NKA in premenopausal women. |
| doi_str_mv | 10.3390/jcm12124027 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10299486</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A758335631</galeid><sourcerecordid>A758335631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-ac6d7a4988822b42523eb26244f66ebd76bcb8a5eea85792de771144384c1f893</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEolXpiTuyxKWIbok_Ejtc0CotFLECicDZcpxJ1ysnXmxn0f4I_jOOWsoW4TmMZT_zjsczWfYc5xeUVvmbjR4wwYTlhD_KjknO-SKngj4-2B9lpyFs8rSEYATzp9kR5bOR_Dj79RWsisaNYW22qIX4E2BEDfhpQLXz0QRnz9ElrPedd7A1akw-RPBuBNRMtlcR0Nnl9dWyeYVWsAMbzlGC0GcVJ68s-mSsBY9qsBYtdTQ7E_dv0RLVSSYsGtBz8sQ1cer2z7InvbIBTu_8Sfb9_dW3-nqx-vLhY71cLTTjPC6ULjuuWCWEIKRlpCAUWlISxvqyhLbjZatboQoAJQpekQ44x5gxKpjGvajoSfbuVnc7tQN0GsaY3iq33gzK76VTRj68Gc1a3ridxDmpKibKpHB2p-DdjwlClIMJOhWpRnBTkETQvCxZQYuEvvwH3bjJp5pnilQCl6lTf6kbZUGasXcpsZ5F5ZIXgtKipDhRF_-hknUwGJ160pt0_iDg9W2Anv_bQ39fJM7lPEHyYIIS_eLwX-7ZP_NCfwMvasBR</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2829816077</pqid></control><display><type>article</type><title>Relationship between Serum Cortisol, Dehydroepiandrosterone Sulfate (DHEAS) Levels, and Natural Killer Cell Activity: A Cross-Sectional Study</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Suh, Eunkyung ; Cho, A-Ra ; Haam, Ji-Hee ; Gil, Minchan ; Lee, Yun-Kyong ; Kim, Young-Sang</creator><creatorcontrib>Suh, Eunkyung ; Cho, A-Ra ; Haam, Ji-Hee ; Gil, Minchan ; Lee, Yun-Kyong ; Kim, Young-Sang</creatorcontrib><description>The adrenal steroid hormones, cortisol and dehydroepiandrosterone sulfate (DHEAS), are associated with the immune system in opposite actions. This study aimed to investigate the relationship between cortisol and DHEAS serum concentrations, their ratio (CDR), and natural killer cell activity (NKA). This cross-sectional study included 2275 subjects without current infection or inflammation in the final analyses. NKA was estimated by measuring the amount of interferon-gamma (IFN-γ) released by activated natural killer cells; low NKA was defined as IFN-γ level < 500 pg/mL. Cortisol, DHEAS levels, and CDRs were categorized by quartiles in men, premenopausal women, and postmenopausal women. Compared with the lowest quartile as reference, the adjusted odd ratios (ORs) and 95% confidence intervals (CIs) for low NKA of the highest cortisol and CDR group were 1.66 (1.09-2.51) and 1.68 (1.11-2.55) in men, 1.58 (1.07-2.33) and 2.33 (1.58-3.46) in premenopausal women, and 2.23 (1.28-3.87) and 1.85 (1.07-3.21) in postmenopausal women. Only in premenopausal women, the highest DHEAS group showed significantly lower risk of low NKA (OR: 0.51, 95% CI: 0.35-0.76). HPA axis activation indicated as high cortisol level, CDR was significantly associated with low NKA, while high DHEAS levels were inversely associated with low NKA in premenopausal women.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12124027</identifier><identifier>PMID: 37373720</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Analysis ; Blood ; Body mass index ; Clinical medicine ; Cross-sectional studies ; Dehydroepiandrosterone ; Disease ; Dosage and administration ; Health aspects ; Hormones ; Hydrocortisone ; Immune response ; Killer cells ; Leukocytes ; Lymphocytes ; Neutrophils ; Postmenopausal women ; Steroids ; Variance analysis ; Womens health</subject><ispartof>Journal of clinical medicine, 2023-06, Vol.12 (12), p.4027</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-ac6d7a4988822b42523eb26244f66ebd76bcb8a5eea85792de771144384c1f893</citedby><cites>FETCH-LOGICAL-c477t-ac6d7a4988822b42523eb26244f66ebd76bcb8a5eea85792de771144384c1f893</cites><orcidid>0000-0002-4972-0047 ; 0000-0002-3645-2282 ; 0000-0002-7397-5410</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299486/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299486/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37373720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suh, Eunkyung</creatorcontrib><creatorcontrib>Cho, A-Ra</creatorcontrib><creatorcontrib>Haam, Ji-Hee</creatorcontrib><creatorcontrib>Gil, Minchan</creatorcontrib><creatorcontrib>Lee, Yun-Kyong</creatorcontrib><creatorcontrib>Kim, Young-Sang</creatorcontrib><title>Relationship between Serum Cortisol, Dehydroepiandrosterone Sulfate (DHEAS) Levels, and Natural Killer Cell Activity: A Cross-Sectional Study</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>The adrenal steroid hormones, cortisol and dehydroepiandrosterone sulfate (DHEAS), are associated with the immune system in opposite actions. This study aimed to investigate the relationship between cortisol and DHEAS serum concentrations, their ratio (CDR), and natural killer cell activity (NKA). This cross-sectional study included 2275 subjects without current infection or inflammation in the final analyses. NKA was estimated by measuring the amount of interferon-gamma (IFN-γ) released by activated natural killer cells; low NKA was defined as IFN-γ level < 500 pg/mL. Cortisol, DHEAS levels, and CDRs were categorized by quartiles in men, premenopausal women, and postmenopausal women. Compared with the lowest quartile as reference, the adjusted odd ratios (ORs) and 95% confidence intervals (CIs) for low NKA of the highest cortisol and CDR group were 1.66 (1.09-2.51) and 1.68 (1.11-2.55) in men, 1.58 (1.07-2.33) and 2.33 (1.58-3.46) in premenopausal women, and 2.23 (1.28-3.87) and 1.85 (1.07-3.21) in postmenopausal women. Only in premenopausal women, the highest DHEAS group showed significantly lower risk of low NKA (OR: 0.51, 95% CI: 0.35-0.76). HPA axis activation indicated as high cortisol level, CDR was significantly associated with low NKA, while high DHEAS levels were inversely associated with low NKA in premenopausal women.</description><subject>Age</subject><subject>Analysis</subject><subject>Blood</subject><subject>Body mass index</subject><subject>Clinical medicine</subject><subject>Cross-sectional studies</subject><subject>Dehydroepiandrosterone</subject><subject>Disease</subject><subject>Dosage and administration</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Hydrocortisone</subject><subject>Immune response</subject><subject>Killer cells</subject><subject>Leukocytes</subject><subject>Lymphocytes</subject><subject>Neutrophils</subject><subject>Postmenopausal women</subject><subject>Steroids</subject><subject>Variance analysis</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkk1v1DAQhiMEolXpiTuyxKWIbok_Ejtc0CotFLECicDZcpxJ1ysnXmxn0f4I_jOOWsoW4TmMZT_zjsczWfYc5xeUVvmbjR4wwYTlhD_KjknO-SKngj4-2B9lpyFs8rSEYATzp9kR5bOR_Dj79RWsisaNYW22qIX4E2BEDfhpQLXz0QRnz9ElrPedd7A1akw-RPBuBNRMtlcR0Nnl9dWyeYVWsAMbzlGC0GcVJ68s-mSsBY9qsBYtdTQ7E_dv0RLVSSYsGtBz8sQ1cer2z7InvbIBTu_8Sfb9_dW3-nqx-vLhY71cLTTjPC6ULjuuWCWEIKRlpCAUWlISxvqyhLbjZatboQoAJQpekQ44x5gxKpjGvajoSfbuVnc7tQN0GsaY3iq33gzK76VTRj68Gc1a3ridxDmpKibKpHB2p-DdjwlClIMJOhWpRnBTkETQvCxZQYuEvvwH3bjJp5pnilQCl6lTf6kbZUGasXcpsZ5F5ZIXgtKipDhRF_-hknUwGJ160pt0_iDg9W2Anv_bQ39fJM7lPEHyYIIS_eLwX-7ZP_NCfwMvasBR</recordid><startdate>20230613</startdate><enddate>20230613</enddate><creator>Suh, Eunkyung</creator><creator>Cho, A-Ra</creator><creator>Haam, Ji-Hee</creator><creator>Gil, Minchan</creator><creator>Lee, Yun-Kyong</creator><creator>Kim, Young-Sang</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4972-0047</orcidid><orcidid>https://orcid.org/0000-0002-3645-2282</orcidid><orcidid>https://orcid.org/0000-0002-7397-5410</orcidid></search><sort><creationdate>20230613</creationdate><title>Relationship between Serum Cortisol, Dehydroepiandrosterone Sulfate (DHEAS) Levels, and Natural Killer Cell Activity: A Cross-Sectional Study</title><author>Suh, Eunkyung ; Cho, A-Ra ; Haam, Ji-Hee ; Gil, Minchan ; Lee, Yun-Kyong ; Kim, Young-Sang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-ac6d7a4988822b42523eb26244f66ebd76bcb8a5eea85792de771144384c1f893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Analysis</topic><topic>Blood</topic><topic>Body mass index</topic><topic>Clinical medicine</topic><topic>Cross-sectional studies</topic><topic>Dehydroepiandrosterone</topic><topic>Disease</topic><topic>Dosage and administration</topic><topic>Health aspects</topic><topic>Hormones</topic><topic>Hydrocortisone</topic><topic>Immune response</topic><topic>Killer cells</topic><topic>Leukocytes</topic><topic>Lymphocytes</topic><topic>Neutrophils</topic><topic>Postmenopausal women</topic><topic>Steroids</topic><topic>Variance analysis</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suh, Eunkyung</creatorcontrib><creatorcontrib>Cho, A-Ra</creatorcontrib><creatorcontrib>Haam, Ji-Hee</creatorcontrib><creatorcontrib>Gil, Minchan</creatorcontrib><creatorcontrib>Lee, Yun-Kyong</creatorcontrib><creatorcontrib>Kim, Young-Sang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suh, Eunkyung</au><au>Cho, A-Ra</au><au>Haam, Ji-Hee</au><au>Gil, Minchan</au><au>Lee, Yun-Kyong</au><au>Kim, Young-Sang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Serum Cortisol, Dehydroepiandrosterone Sulfate (DHEAS) Levels, and Natural Killer Cell Activity: A Cross-Sectional Study</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2023-06-13</date><risdate>2023</risdate><volume>12</volume><issue>12</issue><spage>4027</spage><pages>4027-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>The adrenal steroid hormones, cortisol and dehydroepiandrosterone sulfate (DHEAS), are associated with the immune system in opposite actions. This study aimed to investigate the relationship between cortisol and DHEAS serum concentrations, their ratio (CDR), and natural killer cell activity (NKA). This cross-sectional study included 2275 subjects without current infection or inflammation in the final analyses. NKA was estimated by measuring the amount of interferon-gamma (IFN-γ) released by activated natural killer cells; low NKA was defined as IFN-γ level < 500 pg/mL. Cortisol, DHEAS levels, and CDRs were categorized by quartiles in men, premenopausal women, and postmenopausal women. Compared with the lowest quartile as reference, the adjusted odd ratios (ORs) and 95% confidence intervals (CIs) for low NKA of the highest cortisol and CDR group were 1.66 (1.09-2.51) and 1.68 (1.11-2.55) in men, 1.58 (1.07-2.33) and 2.33 (1.58-3.46) in premenopausal women, and 2.23 (1.28-3.87) and 1.85 (1.07-3.21) in postmenopausal women. Only in premenopausal women, the highest DHEAS group showed significantly lower risk of low NKA (OR: 0.51, 95% CI: 0.35-0.76). HPA axis activation indicated as high cortisol level, CDR was significantly associated with low NKA, while high DHEAS levels were inversely associated with low NKA in premenopausal women.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37373720</pmid><doi>10.3390/jcm12124027</doi><orcidid>https://orcid.org/0000-0002-4972-0047</orcidid><orcidid>https://orcid.org/0000-0002-3645-2282</orcidid><orcidid>https://orcid.org/0000-0002-7397-5410</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2023-06, Vol.12 (12), p.4027 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10299486 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Age Analysis Blood Body mass index Clinical medicine Cross-sectional studies Dehydroepiandrosterone Disease Dosage and administration Health aspects Hormones Hydrocortisone Immune response Killer cells Leukocytes Lymphocytes Neutrophils Postmenopausal women Steroids Variance analysis Womens health |
| title | Relationship between Serum Cortisol, Dehydroepiandrosterone Sulfate (DHEAS) Levels, and Natural Killer Cell Activity: A Cross-Sectional Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T06%3A53%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20Serum%20Cortisol,%20Dehydroepiandrosterone%20Sulfate%20(DHEAS)%20Levels,%20and%20Natural%20Killer%20Cell%20Activity:%20A%20Cross-Sectional%20Study&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Suh,%20Eunkyung&rft.date=2023-06-13&rft.volume=12&rft.issue=12&rft.spage=4027&rft.pages=4027-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm12124027&rft_dat=%3Cgale_pubme%3EA758335631%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2829816077&rft_id=info:pmid/37373720&rft_galeid=A758335631&rfr_iscdi=true |