Molecular BCR::ABL1 Quantification and ABL1 Mutation Detection as Essential Tools for the Clinical Management of Chronic Myeloid Leukemia Patients: Results from a Brazilian Single-Center Study

Chronic myeloid leukemia (CML) is a well-characterized oncological disease in which virtually all patients possess a translocation (9;22) that generates the tyrosine kinase protein. This translocation represents one of the milestones in molecular oncology in terms of both diagnostic and prognostic e...

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Veröffentlicht in:	International journal of molecular sciences 2023-06, Vol.24 (12), p.10118
Hauptverfasser:	Marin, Anelis Maria, Wosniaki, Denise Kusma, Sanchuki, Heloisa Bruna Soligo, Munhoz, Eduardo Cilião, Nardin, Jeanine Marie, Soares, Gabriela Silva, Espinace, Dhienifer Caroline, de Holanda Farias, João Samuel, Veroneze, Bruna, Becker, Luiz Felipe, Costa, Guilherme Lima, Beltrame, Olair Carlos, de Oliveira, Jaqueline Carvalho, Cambri, Geison, Zanette, Dalila Luciola, Aoki, Mateus Nóbrega
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl1 gene BCR-ABL protein Bone marrow Cancer Chronic myeloid leukemia Enzymes Guidelines Health services Kinases Leukemia Molecular biology Mutation Myeloid leukemia Patients Phosphorylation Protein transport Protein-tyrosine kinase Response rates Stem cell transplantation Tyrosine
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