The Effects of Mitochondrial Transplantation on Sepsis Depend on the Type of Cell from Which They Are Isolated
Previously, we have shown that mitochondrial transplantation in the sepsis model has immune modulatory effects. The mitochondrial function could have different characteristics dependent on cell types. Here, we investigated whether the effects of mitochondrial transplantation on the sepsis model coul...
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| Veröffentlicht in: | International journal of molecular sciences 2023-06, Vol.24 (12), p.10113 |
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| creator | Kim, Yun-Seok Lee, Han A Reum Lee, Min Ji Park, Ye Jin Mun, Sehwan Yune, Chang June Chung, Tae Nyoung Bae, Jinkun Kim, Mi Jin Choi, Yong-Soo Kim, Kyuseok |
| description | Previously, we have shown that mitochondrial transplantation in the sepsis model has immune modulatory effects. The mitochondrial function could have different characteristics dependent on cell types. Here, we investigated whether the effects of mitochondrial transplantation on the sepsis model could be different depending on the cell type, from which mitochondria were isolated. We isolated mitochondria from L6 muscle cells, clone 9 liver cells and mesenchymal stem cells (MSC). We tested the effects of mitochondrial transplantation using in vitro and in vivo sepsis models. We used the LPS stimulation of THP-1 cell, a monocyte cell line, as an in vitro model. First, we observed changes in mitochondrial function in the mitochondria-transplanted cells. Second, we compared the anti-inflammatory effects of mitochondrial transplantation. Third, we investigated the immune-enhancing effects using the endotoxin tolerance model. In the in vivo polymicrobial fecal slurry sepsis model, we examined the survival and biochemical effects of each type of mitochondrial transplantation. In the in vitro LPS model, mitochondrial transplantation with each cell type improved mitochondrial function, as measured by oxygen consumption. Among the three cell types, L6-mitochondrial transplantation significantly enhanced mitochondrial function. Mitochondrial transplantation with each cell type reduced hyper-inflammation in the acute phase of in vitro LPS model. It also enhanced immune function during the late immune suppression phase, as shown by endotoxin tolerance. These functions were not significantly different between the three cell types of origin for mitochondrial transplantation. However, only L6-mitochondrial transplantation significantly improved survival compared to the control in the polymicrobial intraabdominal sepsis model. The effects of mitochondria transplantation on both in vitro and in vivo sepsis models differed depending on the cell types of origin for mitochondria. L6-mitochondrial transplantation might be more beneficial in the sepsis model. |
| doi_str_mv | 10.3390/ijms241210113 |
| format | Article |
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The mitochondrial function could have different characteristics dependent on cell types. Here, we investigated whether the effects of mitochondrial transplantation on the sepsis model could be different depending on the cell type, from which mitochondria were isolated. We isolated mitochondria from L6 muscle cells, clone 9 liver cells and mesenchymal stem cells (MSC). We tested the effects of mitochondrial transplantation using in vitro and in vivo sepsis models. We used the LPS stimulation of THP-1 cell, a monocyte cell line, as an in vitro model. First, we observed changes in mitochondrial function in the mitochondria-transplanted cells. Second, we compared the anti-inflammatory effects of mitochondrial transplantation. Third, we investigated the immune-enhancing effects using the endotoxin tolerance model. In the in vivo polymicrobial fecal slurry sepsis model, we examined the survival and biochemical effects of each type of mitochondrial transplantation. In the in vitro LPS model, mitochondrial transplantation with each cell type improved mitochondrial function, as measured by oxygen consumption. Among the three cell types, L6-mitochondrial transplantation significantly enhanced mitochondrial function. Mitochondrial transplantation with each cell type reduced hyper-inflammation in the acute phase of in vitro LPS model. It also enhanced immune function during the late immune suppression phase, as shown by endotoxin tolerance. These functions were not significantly different between the three cell types of origin for mitochondrial transplantation. However, only L6-mitochondrial transplantation significantly improved survival compared to the control in the polymicrobial intraabdominal sepsis model. The effects of mitochondria transplantation on both in vitro and in vivo sepsis models differed depending on the cell types of origin for mitochondria. L6-mitochondrial transplantation might be more beneficial in the sepsis model.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241210113</identifier><identifier>PMID: 37373260</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analysis ; Apoptosis ; Cell growth ; Cloning ; Creatinine ; Endotoxins ; Hepatocytes ; Homeostasis ; Immune response ; Immunological tolerance ; Infection ; Inflammation ; Investigations ; Ischemia ; Lipopolysaccharides ; Mesenchymal stem cells ; Mitochondria ; Monocytes ; Musculoskeletal system ; Oxygen consumption ; Phosphorylation ; Respiration ; Sepsis ; Slurries ; Stem cells ; Survival ; Transplantation</subject><ispartof>International journal of molecular sciences, 2023-06, Vol.24 (12), p.10113</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-3f5bb978fef81a527daf0fdde6185a4638737d69c244ffcf6993b41c43829273</citedby><cites>FETCH-LOGICAL-c483t-3f5bb978fef81a527daf0fdde6185a4638737d69c244ffcf6993b41c43829273</cites><orcidid>0000-0002-8826-1787 ; 0000-0003-3537-4136 ; 0000-0002-8218-8531 ; 0000-0002-0594-5703 ; 0000-0001-9605-7965 ; 0000-0001-8445-8067 ; 0000-0002-7991-9428</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299019/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299019/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37373260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Yun-Seok</creatorcontrib><creatorcontrib>Lee, Han A Reum</creatorcontrib><creatorcontrib>Lee, Min Ji</creatorcontrib><creatorcontrib>Park, Ye Jin</creatorcontrib><creatorcontrib>Mun, Sehwan</creatorcontrib><creatorcontrib>Yune, Chang June</creatorcontrib><creatorcontrib>Chung, Tae Nyoung</creatorcontrib><creatorcontrib>Bae, Jinkun</creatorcontrib><creatorcontrib>Kim, Mi Jin</creatorcontrib><creatorcontrib>Choi, Yong-Soo</creatorcontrib><creatorcontrib>Kim, Kyuseok</creatorcontrib><title>The Effects of Mitochondrial Transplantation on Sepsis Depend on the Type of Cell from Which They Are Isolated</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Previously, we have shown that mitochondrial transplantation in the sepsis model has immune modulatory effects. The mitochondrial function could have different characteristics dependent on cell types. Here, we investigated whether the effects of mitochondrial transplantation on the sepsis model could be different depending on the cell type, from which mitochondria were isolated. We isolated mitochondria from L6 muscle cells, clone 9 liver cells and mesenchymal stem cells (MSC). We tested the effects of mitochondrial transplantation using in vitro and in vivo sepsis models. We used the LPS stimulation of THP-1 cell, a monocyte cell line, as an in vitro model. First, we observed changes in mitochondrial function in the mitochondria-transplanted cells. Second, we compared the anti-inflammatory effects of mitochondrial transplantation. Third, we investigated the immune-enhancing effects using the endotoxin tolerance model. In the in vivo polymicrobial fecal slurry sepsis model, we examined the survival and biochemical effects of each type of mitochondrial transplantation. In the in vitro LPS model, mitochondrial transplantation with each cell type improved mitochondrial function, as measured by oxygen consumption. Among the three cell types, L6-mitochondrial transplantation significantly enhanced mitochondrial function. Mitochondrial transplantation with each cell type reduced hyper-inflammation in the acute phase of in vitro LPS model. It also enhanced immune function during the late immune suppression phase, as shown by endotoxin tolerance. These functions were not significantly different between the three cell types of origin for mitochondrial transplantation. However, only L6-mitochondrial transplantation significantly improved survival compared to the control in the polymicrobial intraabdominal sepsis model. The effects of mitochondria transplantation on both in vitro and in vivo sepsis models differed depending on the cell types of origin for mitochondria. L6-mitochondrial transplantation might be more beneficial in the sepsis model.</description><subject>Analysis</subject><subject>Apoptosis</subject><subject>Cell growth</subject><subject>Cloning</subject><subject>Creatinine</subject><subject>Endotoxins</subject><subject>Hepatocytes</subject><subject>Homeostasis</subject><subject>Immune response</subject><subject>Immunological tolerance</subject><subject>Infection</subject><subject>Inflammation</subject><subject>Investigations</subject><subject>Ischemia</subject><subject>Lipopolysaccharides</subject><subject>Mesenchymal stem cells</subject><subject>Mitochondria</subject><subject>Monocytes</subject><subject>Musculoskeletal system</subject><subject>Oxygen consumption</subject><subject>Phosphorylation</subject><subject>Respiration</subject><subject>Sepsis</subject><subject>Slurries</subject><subject>Stem cells</subject><subject>Survival</subject><subject>Transplantation</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks9rFDEUx4Motq4evUrAi5ep-TGTSU6yrNUWKh4c8BiymZdOlplkTGaF_e_N0lq7RV4gj5fP-4Zv8hB6S8kF54p89Lsps5oySijlz9A5rRmrCBHt80f5GXqV844QxlmjXqIz3pZggpyj0A2AL50Du2QcHf7ml2iHGPrkzYi7ZEKeRxMWs_gYcFk_YM4-488wQ-iPhaUIdIcZjt0bGEfsUpzwz8HbARfxA14nwNc5jmaB_jV64cyY4c39vkLdl8tuc1XdfP96vVnfVLaWfKm4a7Zb1UoHTlLTsLY3jri-B0FlY2rBZTHQC2VZXTtnnVCKb2tqay6ZYi1foU93svN-O0FvISzJjHpOfjLpoKPx-vQk-EHfxt-aEqYUoaoofLhXSPHXHvKiJ59tsWcCxH3WTHIihCCSF_T9E3QX9ykUe4ViSjLKSPOPujUjaB9cLBfbo6het43kVLTlA1fo4j9UiR4mb2MA50v9pKG6a7Ap5pzAPZikRB8HRJ8MSOHfPX6ZB_rvRPA_9BS1Qg</recordid><startdate>20230614</startdate><enddate>20230614</enddate><creator>Kim, Yun-Seok</creator><creator>Lee, Han A Reum</creator><creator>Lee, Min Ji</creator><creator>Park, Ye Jin</creator><creator>Mun, Sehwan</creator><creator>Yune, Chang June</creator><creator>Chung, Tae Nyoung</creator><creator>Bae, Jinkun</creator><creator>Kim, Mi Jin</creator><creator>Choi, Yong-Soo</creator><creator>Kim, Kyuseok</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8826-1787</orcidid><orcidid>https://orcid.org/0000-0003-3537-4136</orcidid><orcidid>https://orcid.org/0000-0002-8218-8531</orcidid><orcidid>https://orcid.org/0000-0002-0594-5703</orcidid><orcidid>https://orcid.org/0000-0001-9605-7965</orcidid><orcidid>https://orcid.org/0000-0001-8445-8067</orcidid><orcidid>https://orcid.org/0000-0002-7991-9428</orcidid></search><sort><creationdate>20230614</creationdate><title>The Effects of Mitochondrial Transplantation on Sepsis Depend on the Type of Cell from Which They Are Isolated</title><author>Kim, Yun-Seok ; Lee, Han A Reum ; Lee, Min Ji ; Park, Ye Jin ; Mun, Sehwan ; Yune, Chang June ; Chung, Tae Nyoung ; Bae, Jinkun ; Kim, Mi Jin ; Choi, Yong-Soo ; Kim, Kyuseok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-3f5bb978fef81a527daf0fdde6185a4638737d69c244ffcf6993b41c43829273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Apoptosis</topic><topic>Cell growth</topic><topic>Cloning</topic><topic>Creatinine</topic><topic>Endotoxins</topic><topic>Hepatocytes</topic><topic>Homeostasis</topic><topic>Immune response</topic><topic>Immunological tolerance</topic><topic>Infection</topic><topic>Inflammation</topic><topic>Investigations</topic><topic>Ischemia</topic><topic>Lipopolysaccharides</topic><topic>Mesenchymal stem cells</topic><topic>Mitochondria</topic><topic>Monocytes</topic><topic>Musculoskeletal system</topic><topic>Oxygen consumption</topic><topic>Phosphorylation</topic><topic>Respiration</topic><topic>Sepsis</topic><topic>Slurries</topic><topic>Stem cells</topic><topic>Survival</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Yun-Seok</creatorcontrib><creatorcontrib>Lee, Han A Reum</creatorcontrib><creatorcontrib>Lee, Min Ji</creatorcontrib><creatorcontrib>Park, Ye Jin</creatorcontrib><creatorcontrib>Mun, Sehwan</creatorcontrib><creatorcontrib>Yune, Chang June</creatorcontrib><creatorcontrib>Chung, Tae Nyoung</creatorcontrib><creatorcontrib>Bae, Jinkun</creatorcontrib><creatorcontrib>Kim, Mi Jin</creatorcontrib><creatorcontrib>Choi, Yong-Soo</creatorcontrib><creatorcontrib>Kim, Kyuseok</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Yun-Seok</au><au>Lee, Han A Reum</au><au>Lee, Min Ji</au><au>Park, Ye Jin</au><au>Mun, Sehwan</au><au>Yune, Chang June</au><au>Chung, Tae Nyoung</au><au>Bae, Jinkun</au><au>Kim, Mi Jin</au><au>Choi, Yong-Soo</au><au>Kim, Kyuseok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Mitochondrial Transplantation on Sepsis Depend on the Type of Cell from Which They Are Isolated</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-06-14</date><risdate>2023</risdate><volume>24</volume><issue>12</issue><spage>10113</spage><pages>10113-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Previously, we have shown that mitochondrial transplantation in the sepsis model has immune modulatory effects. The mitochondrial function could have different characteristics dependent on cell types. Here, we investigated whether the effects of mitochondrial transplantation on the sepsis model could be different depending on the cell type, from which mitochondria were isolated. We isolated mitochondria from L6 muscle cells, clone 9 liver cells and mesenchymal stem cells (MSC). We tested the effects of mitochondrial transplantation using in vitro and in vivo sepsis models. We used the LPS stimulation of THP-1 cell, a monocyte cell line, as an in vitro model. First, we observed changes in mitochondrial function in the mitochondria-transplanted cells. Second, we compared the anti-inflammatory effects of mitochondrial transplantation. Third, we investigated the immune-enhancing effects using the endotoxin tolerance model. In the in vivo polymicrobial fecal slurry sepsis model, we examined the survival and biochemical effects of each type of mitochondrial transplantation. In the in vitro LPS model, mitochondrial transplantation with each cell type improved mitochondrial function, as measured by oxygen consumption. Among the three cell types, L6-mitochondrial transplantation significantly enhanced mitochondrial function. Mitochondrial transplantation with each cell type reduced hyper-inflammation in the acute phase of in vitro LPS model. It also enhanced immune function during the late immune suppression phase, as shown by endotoxin tolerance. These functions were not significantly different between the three cell types of origin for mitochondrial transplantation. However, only L6-mitochondrial transplantation significantly improved survival compared to the control in the polymicrobial intraabdominal sepsis model. The effects of mitochondria transplantation on both in vitro and in vivo sepsis models differed depending on the cell types of origin for mitochondria. L6-mitochondrial transplantation might be more beneficial in the sepsis model.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37373260</pmid><doi>10.3390/ijms241210113</doi><orcidid>https://orcid.org/0000-0002-8826-1787</orcidid><orcidid>https://orcid.org/0000-0003-3537-4136</orcidid><orcidid>https://orcid.org/0000-0002-8218-8531</orcidid><orcidid>https://orcid.org/0000-0002-0594-5703</orcidid><orcidid>https://orcid.org/0000-0001-9605-7965</orcidid><orcidid>https://orcid.org/0000-0001-8445-8067</orcidid><orcidid>https://orcid.org/0000-0002-7991-9428</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Analysis Apoptosis Cell growth Cloning Creatinine Endotoxins Hepatocytes Homeostasis Immune response Immunological tolerance Infection Inflammation Investigations Ischemia Lipopolysaccharides Mesenchymal stem cells Mitochondria Monocytes Musculoskeletal system Oxygen consumption Phosphorylation Respiration Sepsis Slurries Stem cells Survival Transplantation |
| title | The Effects of Mitochondrial Transplantation on Sepsis Depend on the Type of Cell from Which They Are Isolated |
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