Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats

Doxorubicin (DOX) is a highly effective chemotherapy agent prescribed for cancer treatment. However, the clinical use of DOX is limited due to off-target toxicity in healthy tissues. In this regard, hepatic and renal metabolic clearance results in DOX accumulation within these organ systems. Within...

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Veröffentlicht in:	International journal of molecular sciences 2023-06, Vol.24 (12), p.10222
Hauptverfasser:	Boeno, Franccesco P, Patel, Jay, Montalvo, Ryan N, Lapierre-Nguyen, Stephanie S, Schreiber, Claire M, Smuder, Ashley J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Aldosterone Angiotensin Angiotensin II Antimitotic agents Antineoplastic agents Aspartate Aspartate aminotransferase Cancer Chemotherapy Creatinine Cystatin C Cytotoxicity Doxorubicin Enzymes Exercise Females Inflammation Kidneys Liver Males Metabolism Oxidative stress Plasma Preconditioning Proteins Proteinuria Renin Sexes Toxicity Urine Vascular endothelial growth factor
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