Metabolomic Profile and Its Correlation with the Plasmatic Levels of Losartan, EXP3174 and Blood Pressure Control in Hypertensive and Chronic Kidney Disease Patients

Systemic arterial hypertension (SAH) is one of the most prevalent chronic diseases worldwide and, when dysregulated, may cause serious complications. Losartan (LOS) blocks relevant physiological aspects of hypertension, acting mainly on the reduction of peripheral vascular resistance. Complications...

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Veröffentlicht in:	International journal of molecular sciences 2023-06, Vol.24 (12), p.9832
Hauptverfasser:	Santos, Ingrid Souza Reis, Martin-Pastor, Manuel, Tavares Júnior, Alberto Gomes, Queiroz, Kamila Ayres, da Silva Sólon, Lílian Grace, Sousa, Francisco Fábio Oliveira de
Format:	Artikel
Sprache:	eng
Schlagworte:	Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Antihypertensive drugs Bioaccumulation Biochemical markers Biomarkers Blood Pressure Chronic illnesses Chronic kidney failure Correlation Creatinine Drug dosages Drug therapy Fumaric acid Hemodialysis Humans Hypertension Kidney diseases Liquid chromatography Losartan - pharmacology Losartan - therapeutic use Mass spectrometry Mass spectroscopy Metabolism Metabolites Metabolomics Morbidity Nephropathy Pharmacokinetics Physiology Renal failure Renal function Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - drug therapy Structure-function relationships Urea Urea - pharmacology Ureas
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