Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease
Alzheimer's disease (AD) is characterized by excessive formation of beta-amyloid peptides (Aβ), mitochondrial dysfunction, enhanced production of reactive oxygen species (ROS), and altered glycolysis. Since the disease is currently not curable, preventive and supportive approaches are in the fo...
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| Veröffentlicht in: | International journal of molecular sciences 2023-06, Vol.24 (12), p.10029 |
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| creator | Babylon, Lukas Meißner, Julia Eckert, Gunter P |
| description | Alzheimer's disease (AD) is characterized by excessive formation of beta-amyloid peptides (Aβ), mitochondrial dysfunction, enhanced production of reactive oxygen species (ROS), and altered glycolysis. Since the disease is currently not curable, preventive and supportive approaches are in the focus of science. Based on studies of promising single substances, the present study used a mixture (cocktail, SC) of compounds consisting of hesperetin (HstP), magnesium-orotate (MgOr), and folic acid (Fol), as well as the combination (KCC) of caffeine (Cof), kahweol (KW) and cafestol (CF). For all compounds, we showed positive results in SH-SY5Y-APP
cells-a model of early AD. Thus, SH-SY5Y-APP
cells were incubated with SC and the activity of the mitochondrial respiration chain complexes were measured, as well as levels of ATP, Aβ, ROS, lactate and pyruvate. Incubation of SH-SY5Y-APP
cells with SC significantly increased the endogenous respiration of mitochondria and ATP levels, while Aβ
levels were significantly decreased. Incubation with SC showed no significant effects on oxidative stress and glycolysis. In summary, this combination of compounds with proven effects on mitochondrial parameters has the potential to improve mitochondrial dysfunction in a cellular model of AD. |
| doi_str_mv | 10.3390/ijms241210029 |
| format | Article |
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cells-a model of early AD. Thus, SH-SY5Y-APP
cells were incubated with SC and the activity of the mitochondrial respiration chain complexes were measured, as well as levels of ATP, Aβ, ROS, lactate and pyruvate. Incubation of SH-SY5Y-APP
cells with SC significantly increased the endogenous respiration of mitochondria and ATP levels, while Aβ
levels were significantly decreased. Incubation with SC showed no significant effects on oxidative stress and glycolysis. In summary, this combination of compounds with proven effects on mitochondrial parameters has the potential to improve mitochondrial dysfunction in a cellular model of AD.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241210029</identifier><identifier>PMID: 37373177</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Advertising executives ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Amyloid beta-Peptides - metabolism ; Analysis ; Bioavailability ; Caffeine ; Caffeine - pharmacology ; Care and treatment ; Cell Line, Tumor ; Coffee ; Dementia ; Diterpenes - pharmacology ; Electron transport ; Enzymes ; Folic acid ; Folic Acid - pharmacology ; Glucose metabolism ; Glycolysis ; Hesperidin ; Hesperidin - pharmacology ; Humans ; Magnesium ; Metabolism ; Metabolites ; Micronutrients - pharmacology ; Mitochondria ; Mitochondria - drug effects ; Mitochondria - metabolism ; Orotic Acid - pharmacology ; Oxidative stress ; Peptide Fragments - metabolism ; Peptides ; Plant metabolites ; Pyruvic acid ; Reactive oxygen species ; Respiration ; Secondary Metabolism ; β-Amyloid</subject><ispartof>International journal of molecular sciences, 2023-06, Vol.24 (12), p.10029</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c439t-a718da8967b1d8c35351ae08e8474c12f2b02caa681e409655befb727077bc193</cites><orcidid>0000-0002-7740-0753</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297858/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297858/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37373177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babylon, Lukas</creatorcontrib><creatorcontrib>Meißner, Julia</creatorcontrib><creatorcontrib>Eckert, Gunter P</creatorcontrib><title>Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Alzheimer's disease (AD) is characterized by excessive formation of beta-amyloid peptides (Aβ), mitochondrial dysfunction, enhanced production of reactive oxygen species (ROS), and altered glycolysis. Since the disease is currently not curable, preventive and supportive approaches are in the focus of science. Based on studies of promising single substances, the present study used a mixture (cocktail, SC) of compounds consisting of hesperetin (HstP), magnesium-orotate (MgOr), and folic acid (Fol), as well as the combination (KCC) of caffeine (Cof), kahweol (KW) and cafestol (CF). For all compounds, we showed positive results in SH-SY5Y-APP
cells-a model of early AD. Thus, SH-SY5Y-APP
cells were incubated with SC and the activity of the mitochondrial respiration chain complexes were measured, as well as levels of ATP, Aβ, ROS, lactate and pyruvate. Incubation of SH-SY5Y-APP
cells with SC significantly increased the endogenous respiration of mitochondria and ATP levels, while Aβ
levels were significantly decreased. Incubation with SC showed no significant effects on oxidative stress and glycolysis. In summary, this combination of compounds with proven effects on mitochondrial parameters has the potential to improve mitochondrial dysfunction in a cellular model of AD.</description><subject>Advertising executives</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Analysis</subject><subject>Bioavailability</subject><subject>Caffeine</subject><subject>Caffeine - pharmacology</subject><subject>Care and treatment</subject><subject>Cell Line, Tumor</subject><subject>Coffee</subject><subject>Dementia</subject><subject>Diterpenes - pharmacology</subject><subject>Electron transport</subject><subject>Enzymes</subject><subject>Folic acid</subject><subject>Folic Acid - pharmacology</subject><subject>Glucose metabolism</subject><subject>Glycolysis</subject><subject>Hesperidin</subject><subject>Hesperidin - pharmacology</subject><subject>Humans</subject><subject>Magnesium</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Micronutrients - pharmacology</subject><subject>Mitochondria</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Orotic Acid - pharmacology</subject><subject>Oxidative stress</subject><subject>Peptide Fragments - metabolism</subject><subject>Peptides</subject><subject>Plant metabolites</subject><subject>Pyruvic acid</subject><subject>Reactive oxygen species</subject><subject>Respiration</subject><subject>Secondary Metabolism</subject><subject>β-Amyloid</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1v1DAQhi0EomXhyBVZ4gCXFH8kcXJCq6WFSl2BBJwtx5l0vXLsxU4qlZ_Ar2aWlmoXIR9seZ55R-_MEPKSszMpW_bObccsSi44Y6J9RE55KUTBWK0eH7xPyLOct0hIUbVPyYlUeLhSp-TXKo6dC2ZyMdA40K9gY-hNuqVfvAkTXcNkuujdBJma0NO1symGeUoOwpTp5bhL8QZjazdFu8HU5IynF3OwfxRdoIauwHu6jj34fYVzk_wtXfqfG3AjpDeZfnAZTIbn5MlgfIYX9_eCfL84_7b6VFx9_ni5Wl4VtpTtVBjFm940ba063jdWVrLiBlgDTalKy8UgOiasMXXDoWRtXVUdDJ0SiinVWd7KBXl_p7ubuxF6i0aS8XqX3Ii-dTROH0eC2-jreKM5dlg1VYMKb-8VUvwxQ5706LJFlyZAnLMWjWR1Xcu2QvT1P-g2zimgP6RE2whesgPq2njQLgwRC9u9qF4qLMjrCge2IGf_ofD0MDocGwwO_48SirsEnFnOCYYHk5zp_fboo-1B_tVhZx7ov-sifwO9s8DE</recordid><startdate>20230612</startdate><enddate>20230612</enddate><creator>Babylon, Lukas</creator><creator>Meißner, Julia</creator><creator>Eckert, Gunter P</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7740-0753</orcidid></search><sort><creationdate>20230612</creationdate><title>Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease</title><author>Babylon, Lukas ; Meißner, Julia ; Eckert, Gunter P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-a718da8967b1d8c35351ae08e8474c12f2b02caa681e409655befb727077bc193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Advertising executives</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Analysis</topic><topic>Bioavailability</topic><topic>Caffeine</topic><topic>Caffeine - pharmacology</topic><topic>Care and treatment</topic><topic>Cell Line, Tumor</topic><topic>Coffee</topic><topic>Dementia</topic><topic>Diterpenes - pharmacology</topic><topic>Electron transport</topic><topic>Enzymes</topic><topic>Folic acid</topic><topic>Folic Acid - pharmacology</topic><topic>Glucose metabolism</topic><topic>Glycolysis</topic><topic>Hesperidin</topic><topic>Hesperidin - pharmacology</topic><topic>Humans</topic><topic>Magnesium</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Micronutrients - pharmacology</topic><topic>Mitochondria</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Orotic Acid - pharmacology</topic><topic>Oxidative stress</topic><topic>Peptide Fragments - metabolism</topic><topic>Peptides</topic><topic>Plant metabolites</topic><topic>Pyruvic acid</topic><topic>Reactive oxygen species</topic><topic>Respiration</topic><topic>Secondary Metabolism</topic><topic>β-Amyloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babylon, Lukas</creatorcontrib><creatorcontrib>Meißner, Julia</creatorcontrib><creatorcontrib>Eckert, Gunter P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babylon, Lukas</au><au>Meißner, Julia</au><au>Eckert, Gunter P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-06-12</date><risdate>2023</risdate><volume>24</volume><issue>12</issue><spage>10029</spage><pages>10029-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Alzheimer's disease (AD) is characterized by excessive formation of beta-amyloid peptides (Aβ), mitochondrial dysfunction, enhanced production of reactive oxygen species (ROS), and altered glycolysis. Since the disease is currently not curable, preventive and supportive approaches are in the focus of science. Based on studies of promising single substances, the present study used a mixture (cocktail, SC) of compounds consisting of hesperetin (HstP), magnesium-orotate (MgOr), and folic acid (Fol), as well as the combination (KCC) of caffeine (Cof), kahweol (KW) and cafestol (CF). For all compounds, we showed positive results in SH-SY5Y-APP
cells-a model of early AD. Thus, SH-SY5Y-APP
cells were incubated with SC and the activity of the mitochondrial respiration chain complexes were measured, as well as levels of ATP, Aβ, ROS, lactate and pyruvate. Incubation of SH-SY5Y-APP
cells with SC significantly increased the endogenous respiration of mitochondria and ATP levels, while Aβ
levels were significantly decreased. Incubation with SC showed no significant effects on oxidative stress and glycolysis. In summary, this combination of compounds with proven effects on mitochondrial parameters has the potential to improve mitochondrial dysfunction in a cellular model of AD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37373177</pmid><doi>10.3390/ijms241210029</doi><orcidid>https://orcid.org/0000-0002-7740-0753</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2023-06, Vol.24 (12), p.10029 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Advertising executives Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Analysis Bioavailability Caffeine Caffeine - pharmacology Care and treatment Cell Line, Tumor Coffee Dementia Diterpenes - pharmacology Electron transport Enzymes Folic acid Folic Acid - pharmacology Glucose metabolism Glycolysis Hesperidin Hesperidin - pharmacology Humans Magnesium Metabolism Metabolites Micronutrients - pharmacology Mitochondria Mitochondria - drug effects Mitochondria - metabolism Orotic Acid - pharmacology Oxidative stress Peptide Fragments - metabolism Peptides Plant metabolites Pyruvic acid Reactive oxygen species Respiration Secondary Metabolism β-Amyloid |
| title | Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease |
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