B7H3 Role in Reshaping Immunosuppressive Landscape in MSI and MSS Colorectal Cancer Tumours
The study aimed to assess the expression of B7H3 concerning clinicopathological and histological parameters, including MSI/MSS status, CD-8 cells, tumour-infiltrating lymphocytes (TILs), budding, TNM scale and grading. Moreover, we analyzed the B7H3-related pathways using available online datasets a...
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| Veröffentlicht in: | Cancers 2023-06, Vol.15 (12), p.3136 |
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| creator | Mielcarska, Sylwia Dawidowicz, Miriam Kula, Agnieszka Kiczmer, Paweł Skiba, Hanna Krygier, Małgorzata Chrabańska, Magdalena Piecuch, Jerzy Szrot, Monika Ochman, Błażej Robotycka, Julia Strzałkowska, Bogumiła Czuba, Zenon Waniczek, Dariusz Świętochowska, Elżbieta |
| description | The study aimed to assess the expression of B7H3 concerning clinicopathological and histological parameters, including MSI/MSS status, CD-8 cells, tumour-infiltrating lymphocytes (TILs), budding, TNM scale and grading. Moreover, we analyzed the B7H3-related pathways using available online datasets and the immunological context of B7H3 expression, through the 48-cytokine screening panel of cancer tissues homogenates, immunogenic features and immune composition. The study included 158 patients diagnosed with CRC. To assess B7H3 levels, we performed an immunohistochemistry method (IHC) and enzyme-linked immunosorbent assay (ELISA). To elucidate the immune composition of colorectal cancer, we performed the Bio-Plex Pro Human 48-cytokine panel. To study biological characteristics of B7H3, we used online databases. Expression of B7H3 was upregulated in CRC tumour tissues in comparison to adjacent noncancerous margin tissues. The concentrations of B7H3 in tumours were positively associated with T parameter of patients and negatively with tumour-infiltrating lymphocytes score. Additionally, Principal Component Analysis showed that B7H3 expression in tumours correlated positively with cytokines associated with M2-macrophages and protumour growth factors. The expression of B7H3 in tumours was independent of MSI/MSS status. These findings will improve our understanding of B7H3 role in colorectal cancer immunity. Our study suggests that B7-H3 is a promising potential target for cancer therapy. Further studies must clarify the mechanisms of B7H3 overexpression and its therapeutic importance in colorectal cancer. |
| doi_str_mv | 10.3390/cancers15123136 |
| format | Article |
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Moreover, we analyzed the B7H3-related pathways using available online datasets and the immunological context of B7H3 expression, through the 48-cytokine screening panel of cancer tissues homogenates, immunogenic features and immune composition. The study included 158 patients diagnosed with CRC. To assess B7H3 levels, we performed an immunohistochemistry method (IHC) and enzyme-linked immunosorbent assay (ELISA). To elucidate the immune composition of colorectal cancer, we performed the Bio-Plex Pro Human 48-cytokine panel. To study biological characteristics of B7H3, we used online databases. Expression of B7H3 was upregulated in CRC tumour tissues in comparison to adjacent noncancerous margin tissues. The concentrations of B7H3 in tumours were positively associated with T parameter of patients and negatively with tumour-infiltrating lymphocytes score. Additionally, Principal Component Analysis showed that B7H3 expression in tumours correlated positively with cytokines associated with M2-macrophages and protumour growth factors. The expression of B7H3 in tumours was independent of MSI/MSS status. These findings will improve our understanding of B7H3 role in colorectal cancer immunity. Our study suggests that B7-H3 is a promising potential target for cancer therapy. Further studies must clarify the mechanisms of B7H3 overexpression and its therapeutic importance in colorectal cancer.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15123136</identifier><identifier>PMID: 37370746</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analysis ; Antigens ; Cancer ; Cancer therapies ; Colorectal cancer ; Colorectal carcinoma ; Cytokines ; Diagnosis ; Enzyme-linked immunosorbent assay ; Growth factors ; Health aspects ; Immune system ; Immunity ; Immunogenicity ; Immunohistochemistry ; Immunotherapy ; Lymphocytes ; Macrophages ; Malignancy ; Medical research ; Medicine, Experimental ; Monoclonal antibodies ; PD-1 protein ; PD-L1 protein ; Principal components analysis ; Proteins ; Reagents ; Stains & staining ; Tumors ; Yeast</subject><ispartof>Cancers, 2023-06, Vol.15 (12), p.3136</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-424b56a985f5b71212487018fd5ecbd770ecf08363762e0514e4f5c0a07022f03</citedby><cites>FETCH-LOGICAL-c489t-424b56a985f5b71212487018fd5ecbd770ecf08363762e0514e4f5c0a07022f03</cites><orcidid>0000-0001-8216-4495 ; 0000-0001-9060-0154 ; 0000-0002-1237-059X ; 0000-0002-3668-151X ; 0000-0002-0410-8604</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296380/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296380/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37370746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mielcarska, Sylwia</creatorcontrib><creatorcontrib>Dawidowicz, Miriam</creatorcontrib><creatorcontrib>Kula, Agnieszka</creatorcontrib><creatorcontrib>Kiczmer, Paweł</creatorcontrib><creatorcontrib>Skiba, Hanna</creatorcontrib><creatorcontrib>Krygier, Małgorzata</creatorcontrib><creatorcontrib>Chrabańska, Magdalena</creatorcontrib><creatorcontrib>Piecuch, Jerzy</creatorcontrib><creatorcontrib>Szrot, Monika</creatorcontrib><creatorcontrib>Ochman, Błażej</creatorcontrib><creatorcontrib>Robotycka, Julia</creatorcontrib><creatorcontrib>Strzałkowska, Bogumiła</creatorcontrib><creatorcontrib>Czuba, Zenon</creatorcontrib><creatorcontrib>Waniczek, Dariusz</creatorcontrib><creatorcontrib>Świętochowska, Elżbieta</creatorcontrib><title>B7H3 Role in Reshaping Immunosuppressive Landscape in MSI and MSS Colorectal Cancer Tumours</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>The study aimed to assess the expression of B7H3 concerning clinicopathological and histological parameters, including MSI/MSS status, CD-8 cells, tumour-infiltrating lymphocytes (TILs), budding, TNM scale and grading. Moreover, we analyzed the B7H3-related pathways using available online datasets and the immunological context of B7H3 expression, through the 48-cytokine screening panel of cancer tissues homogenates, immunogenic features and immune composition. The study included 158 patients diagnosed with CRC. To assess B7H3 levels, we performed an immunohistochemistry method (IHC) and enzyme-linked immunosorbent assay (ELISA). To elucidate the immune composition of colorectal cancer, we performed the Bio-Plex Pro Human 48-cytokine panel. To study biological characteristics of B7H3, we used online databases. Expression of B7H3 was upregulated in CRC tumour tissues in comparison to adjacent noncancerous margin tissues. The concentrations of B7H3 in tumours were positively associated with T parameter of patients and negatively with tumour-infiltrating lymphocytes score. Additionally, Principal Component Analysis showed that B7H3 expression in tumours correlated positively with cytokines associated with M2-macrophages and protumour growth factors. The expression of B7H3 in tumours was independent of MSI/MSS status. These findings will improve our understanding of B7H3 role in colorectal cancer immunity. Our study suggests that B7-H3 is a promising potential target for cancer therapy. Further studies must clarify the mechanisms of B7H3 overexpression and its therapeutic importance in colorectal cancer.</description><subject>Analysis</subject><subject>Antigens</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunogenicity</subject><subject>Immunohistochemistry</subject><subject>Immunotherapy</subject><subject>Lymphocytes</subject><subject>Macrophages</subject><subject>Malignancy</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Monoclonal antibodies</subject><subject>PD-1 protein</subject><subject>PD-L1 protein</subject><subject>Principal components 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(Basel)</addtitle><date>2023-06-10</date><risdate>2023</risdate><volume>15</volume><issue>12</issue><spage>3136</spage><pages>3136-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>The study aimed to assess the expression of B7H3 concerning clinicopathological and histological parameters, including MSI/MSS status, CD-8 cells, tumour-infiltrating lymphocytes (TILs), budding, TNM scale and grading. Moreover, we analyzed the B7H3-related pathways using available online datasets and the immunological context of B7H3 expression, through the 48-cytokine screening panel of cancer tissues homogenates, immunogenic features and immune composition. The study included 158 patients diagnosed with CRC. To assess B7H3 levels, we performed an immunohistochemistry method (IHC) and enzyme-linked immunosorbent assay (ELISA). To elucidate the immune composition of colorectal cancer, we performed the Bio-Plex Pro Human 48-cytokine panel. To study biological characteristics of B7H3, we used online databases. Expression of B7H3 was upregulated in CRC tumour tissues in comparison to adjacent noncancerous margin tissues. The concentrations of B7H3 in tumours were positively associated with T parameter of patients and negatively with tumour-infiltrating lymphocytes score. Additionally, Principal Component Analysis showed that B7H3 expression in tumours correlated positively with cytokines associated with M2-macrophages and protumour growth factors. The expression of B7H3 in tumours was independent of MSI/MSS status. These findings will improve our understanding of B7H3 role in colorectal cancer immunity. Our study suggests that B7-H3 is a promising potential target for cancer therapy. Further studies must clarify the mechanisms of B7H3 overexpression and its therapeutic importance in colorectal cancer.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37370746</pmid><doi>10.3390/cancers15123136</doi><orcidid>https://orcid.org/0000-0001-8216-4495</orcidid><orcidid>https://orcid.org/0000-0001-9060-0154</orcidid><orcidid>https://orcid.org/0000-0002-1237-059X</orcidid><orcidid>https://orcid.org/0000-0002-3668-151X</orcidid><orcidid>https://orcid.org/0000-0002-0410-8604</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancers, 2023-06, Vol.15 (12), p.3136 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Analysis Antigens Cancer Cancer therapies Colorectal cancer Colorectal carcinoma Cytokines Diagnosis Enzyme-linked immunosorbent assay Growth factors Health aspects Immune system Immunity Immunogenicity Immunohistochemistry Immunotherapy Lymphocytes Macrophages Malignancy Medical research Medicine, Experimental Monoclonal antibodies PD-1 protein PD-L1 protein Principal components analysis Proteins Reagents Stains & staining Tumors Yeast |
| title | B7H3 Role in Reshaping Immunosuppressive Landscape in MSI and MSS Colorectal Cancer Tumours |
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