Tuberculin response in preterm infants after BCG vaccination at birth
A total of 101 preterm infants between 26 and 37 weeks' gestation who received BCG vaccination at birth were evaluated between two and four months after vaccination. Altogether 32% of these infants had no visible BCG scar. All infants were then tested with tuberculin purified protein derivative...
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| Veröffentlicht in: | Archives of disease in childhood 1993-09, Vol.69 (3 Spec No), p.309-311 |
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| creator | Sedaghatian, M R Kardouni, K |
| description | A total of 101 preterm infants between 26 and 37 weeks' gestation who received BCG vaccination at birth were evaluated between two and four months after vaccination. Altogether 32% of these infants had no visible BCG scar. All infants were then tested with tuberculin purified protein derivative (PPD) but only 70 returned for the test to be read 48-72 hours later. The test was negative in 22 (31%) and there was an induration of < or = 5 mm in another 26 (37%) of the infants. Of 22 infants with no BCG scar, 19 (86%) had an induration of < or = 5 mm. In infants with a positive BCG scar a significantly higher number had an induration of PPD > 5 mm. There were no significant differences between the rate of scarring and tuberculin conversion in the infants born before or after 32 weeks' gestation. It is considered that routine BCG vaccination at birth on preterm infants is not indicated until a much larger study has been performed. |
| doi_str_mv | 10.1136/adc.69.3_Spec_No.309 |
| format | Article |
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Altogether 32% of these infants had no visible BCG scar. All infants were then tested with tuberculin purified protein derivative (PPD) but only 70 returned for the test to be read 48-72 hours later. The test was negative in 22 (31%) and there was an induration of < or = 5 mm in another 26 (37%) of the infants. Of 22 infants with no BCG scar, 19 (86%) had an induration of < or = 5 mm. In infants with a positive BCG scar a significantly higher number had an induration of PPD > 5 mm. There were no significant differences between the rate of scarring and tuberculin conversion in the infants born before or after 32 weeks' gestation. It is considered that routine BCG vaccination at birth on preterm infants is not indicated until a much larger study has been performed.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.69.3_Spec_No.309</identifier><identifier>PMID: 8215572</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Bacillus Calmette-Guerin vaccine ; BCG ; BCG Vaccine - administration & dosage ; BCG Vaccine - immunology ; Biological and medical sciences ; Birth ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Follow-Up Studies ; Gestation ; Humans ; Immunization ; Infant ; Infant, Newborn ; Infant, Premature - immunology ; Infants ; Intensive care medicine ; Medical sciences ; Neonates ; Newborn babies ; Pregnancy ; Premature babies ; Premature Infants ; Scars ; Tuberculin ; Tuberculin Test ; Tuberculosis - prevention & control ; Vaccination ; Young Children</subject><ispartof>Archives of disease in childhood, 1993-09, Vol.69 (3 Spec No), p.309-311</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Sep 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b538t-dbe88fe82276e2a8083f7c1d53bbece12a54ec76a4d7a2eaab1e17e0665c02b53</citedby><cites>FETCH-LOGICAL-b538t-dbe88fe82276e2a8083f7c1d53bbece12a54ec76a4d7a2eaab1e17e0665c02b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1029499/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1029499/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4882834$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8215572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sedaghatian, M R</creatorcontrib><creatorcontrib>Kardouni, K</creatorcontrib><title>Tuberculin response in preterm infants after BCG vaccination at birth</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>A total of 101 preterm infants between 26 and 37 weeks' gestation who received BCG vaccination at birth were evaluated between two and four months after vaccination. Altogether 32% of these infants had no visible BCG scar. All infants were then tested with tuberculin purified protein derivative (PPD) but only 70 returned for the test to be read 48-72 hours later. The test was negative in 22 (31%) and there was an induration of < or = 5 mm in another 26 (37%) of the infants. Of 22 infants with no BCG scar, 19 (86%) had an induration of < or = 5 mm. In infants with a positive BCG scar a significantly higher number had an induration of PPD > 5 mm. There were no significant differences between the rate of scarring and tuberculin conversion in the infants born before or after 32 weeks' gestation. It is considered that routine BCG vaccination at birth on preterm infants is not indicated until a much larger study has been performed.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Bacillus Calmette-Guerin vaccine</subject><subject>BCG</subject><subject>BCG Vaccine - administration & dosage</subject><subject>BCG Vaccine - immunology</subject><subject>Biological and medical sciences</subject><subject>Birth</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Follow-Up Studies</subject><subject>Gestation</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - immunology</subject><subject>Infants</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Pregnancy</subject><subject>Premature babies</subject><subject>Premature Infants</subject><subject>Scars</subject><subject>Tuberculin</subject><subject>Tuberculin Test</subject><subject>Tuberculosis - prevention & control</subject><subject>Vaccination</subject><subject>Young Children</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkV-L1DAUxYMo67j6DRQKim-dzZ82SV-EdVhXYRiVXdfHcJveuhnbtCbtot_eLDMU9cmn3HB-93Auh5DnjK4ZE_IMGruW1VqYqxGt2Q1rQasHZMUKqXNOi-IhWVFKRV5prR-TJzHuKWVca3FCTjRnZan4ilxczzUGO3fOZwHjOPiIWZrHgBOGPo0t-Clm0KZv9nZzmd2Btc7D5AafwZTVLky3T8mjFrqIz47vKfny7uJ68z7ffrz8sDnf5nUp9JQ3NWrdouZcSeSgqRatsqwpRV2jRcahLNAqCUWjgCNAzZAppFKWlvLkcUreHHzHue6xseinAJ0Zg-sh_DIDOPO34t2t-TbcGUZ5VVRVMnh9NAjDjxnjZHoXLXYdeBzmaJSknDIqE_jyH3A_zMGn44ygquKaVpImqjhQNgwxBmyXKIya-5JMKsnIyiwlpe37FC_-PGNZOraS9FdHHaKFrg3grYsLVmjNtSgSlh8wFyf8ucgQvhuphCrN7mZjvl7dbHefmDSfE3924Ot-_39BfwOvab0R</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Sedaghatian, M R</creator><creator>Kardouni, K</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930901</creationdate><title>Tuberculin response in preterm infants after BCG vaccination at birth</title><author>Sedaghatian, M R ; Kardouni, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b538t-dbe88fe82276e2a8083f7c1d53bbece12a54ec76a4d7a2eaab1e17e0665c02b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Bacillus Calmette-Guerin vaccine</topic><topic>BCG</topic><topic>BCG Vaccine - administration & dosage</topic><topic>BCG Vaccine - immunology</topic><topic>Biological and medical sciences</topic><topic>Birth</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Follow-Up Studies</topic><topic>Gestation</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - immunology</topic><topic>Infants</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Pregnancy</topic><topic>Premature babies</topic><topic>Premature Infants</topic><topic>Scars</topic><topic>Tuberculin</topic><topic>Tuberculin Test</topic><topic>Tuberculosis - prevention & control</topic><topic>Vaccination</topic><topic>Young Children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sedaghatian, M R</creatorcontrib><creatorcontrib>Kardouni, K</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sedaghatian, M R</au><au>Kardouni, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuberculin response in preterm infants after BCG vaccination at birth</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>69</volume><issue>3 Spec No</issue><spage>309</spage><epage>311</epage><pages>309-311</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>A total of 101 preterm infants between 26 and 37 weeks' gestation who received BCG vaccination at birth were evaluated between two and four months after vaccination. Altogether 32% of these infants had no visible BCG scar. All infants were then tested with tuberculin purified protein derivative (PPD) but only 70 returned for the test to be read 48-72 hours later. The test was negative in 22 (31%) and there was an induration of < or = 5 mm in another 26 (37%) of the infants. Of 22 infants with no BCG scar, 19 (86%) had an induration of < or = 5 mm. In infants with a positive BCG scar a significantly higher number had an induration of PPD > 5 mm. There were no significant differences between the rate of scarring and tuberculin conversion in the infants born before or after 32 weeks' gestation. It is considered that routine BCG vaccination at birth on preterm infants is not indicated until a much larger study has been performed.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>8215572</pmid><doi>10.1136/adc.69.3_Spec_No.309</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - administration & dosage BCG Vaccine - immunology Biological and medical sciences Birth Emergency and intensive care: neonates and children. Prematurity. Sudden death Follow-Up Studies Gestation Humans Immunization Infant Infant, Newborn Infant, Premature - immunology Infants Intensive care medicine Medical sciences Neonates Newborn babies Pregnancy Premature babies Premature Infants Scars Tuberculin Tuberculin Test Tuberculosis - prevention & control Vaccination Young Children |
| title | Tuberculin response in preterm infants after BCG vaccination at birth |
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