Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients
Aim To elucidate the association of serum irisin levels with bone mineral density (BMD) and calcium–phosphorus metabolism parameters in chronic kidney disease (CKD) patients and renal transplant recipients (RTRs). Methods This is a cross-sectional study involving CKD patients and RTRs. Healthy volun...
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| Veröffentlicht in: | International urology and nephrology 2023-07, Vol.55 (7), p.1821-1828 |
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| creator | Demir, Canan Dursun, Ali Doğan Sarıyıldız, Gülçin Türkmen Arslan, Aykut İlker |
| description | Aim
To elucidate the association of serum irisin levels with bone mineral density (BMD) and calcium–phosphorus metabolism parameters in chronic kidney disease (CKD) patients and renal transplant recipients (RTRs).
Methods
This is a cross-sectional study involving CKD patients and RTRs. Healthy volunteers served as controls. Age, gender, and dialysis vintage were recorded. Serum irisin, creatinine, glucose, calcium, albumin, 25(OH) vitamin D, ferritin, C-reactive protein, A1C, and lipid profile were studied in all participants. Estimated glomerular filtration rate (eGFR), corrected calcium, and body mass index (BMI) were calculated.
Results
Overall, 49 patients (23 hemodialysis, 26 RTRs) and 25 control subjects were included. In hemodialysis (HD) group, 8 patients (34.8%) had osteoporosis, and 12 patients (52.2%) had osteopenia. In RTR group, 3 patients (11.5%) had osteoporosis, while 15 patients (57.7%) had osteopenia. Among controls, one had osteoporosis, and 7 had osteopenia. There was no significant difference between HD and RTRs; however, osteoporosis rate was significantly lower in control subjects. BMD measurements (femur and lumbar T- and Z-scores) were comparable between HD and RTR groups. Control group DEXA values were similar to RTRs; however, they were significantly higher compared to HD group. 25(OH) vitamin D levels were comparable between the HD and RTR groups, and these were significantly lower compared to values of the control group. Mean serum irisin level was 426.6 ± 191.2 pg/mL in hemodialysis group, 342.6 ± 174.8 in the RTR group, and 208.0 ± 186.1 in controls. Serum irisin levels were similar in RTR and HD groups, but their values were significantly higher compared to controls. When we compared serum irisin levels between patients with and without osteoporosis in the whole cohort and hemodialysis and RTR groups, there was no difference. Serum irisin was positively correlated with lumbar T-score both in hemodialysis and RTR groups.
Conclusion
Our study is the first in the literature revealing the positive correlation of serum irisin level with femur T-score in RTRs. Serum irisin level was also positively correlated with femur T-scores in hemodialysis patients. |
| doi_str_mv | 10.1007/s11255-023-03475-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10293367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2775620766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-7d33e9e6445bcd059d017a3cce70e441a681c9ac9d4fc68181ce513cf7e122bb3</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhi0E4qv9Az1Ulrj0kuKPOE5OFUKFVkLiAD1bXnuWNc3aqSdZxL_Hu0sp5cDJY887z3jmJeQTZ185Y_oUORdKVUzIislaq0rvkEOutKyEauvdV_EBOUK8Z4x1LWP75EA2WkvB9SGZbiBPSxpywBBpDyvokdroacIR0pBywoC0pAY7Bogj0ocwLqj1KxsdeOoWOcXg6O_gIzxSHxAswoaQIdqejtlGHHobx_LgwrCBfCB7c9sjfHw-j8mvi--35z-qq-vLn-dnV5WrRTNW2ksJHTR1rWbOM9V5xrWVzoFmUNfcNi13nXWdr-euxOUGiks318CFmM3kMfm25Q7TbAneld7Z9mbIYWnzo0k2mP8zMSzMXVoZzkQny5YK4cszIac_E-BolgEd9GUgSBMaobVqBNNNU6Qnb6T3acplB0XVik61neJroNiqXFktZpi__IYzs7bVbG01xVazsdWsiz6_nuOl5K-PRSC3AiypeAf5X-93sE-fkrD4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2829589517</pqid></control><display><type>article</type><title>Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients</title><source>MEDLINE</source><source>Springer Journals</source><creator>Demir, Canan ; Dursun, Ali Doğan ; Sarıyıldız, Gülçin Türkmen ; Arslan, Aykut İlker</creator><creatorcontrib>Demir, Canan ; Dursun, Ali Doğan ; Sarıyıldız, Gülçin Türkmen ; Arslan, Aykut İlker</creatorcontrib><description>Aim
To elucidate the association of serum irisin levels with bone mineral density (BMD) and calcium–phosphorus metabolism parameters in chronic kidney disease (CKD) patients and renal transplant recipients (RTRs).
Methods
This is a cross-sectional study involving CKD patients and RTRs. Healthy volunteers served as controls. Age, gender, and dialysis vintage were recorded. Serum irisin, creatinine, glucose, calcium, albumin, 25(OH) vitamin D, ferritin, C-reactive protein, A1C, and lipid profile were studied in all participants. Estimated glomerular filtration rate (eGFR), corrected calcium, and body mass index (BMI) were calculated.
Results
Overall, 49 patients (23 hemodialysis, 26 RTRs) and 25 control subjects were included. In hemodialysis (HD) group, 8 patients (34.8%) had osteoporosis, and 12 patients (52.2%) had osteopenia. In RTR group, 3 patients (11.5%) had osteoporosis, while 15 patients (57.7%) had osteopenia. Among controls, one had osteoporosis, and 7 had osteopenia. There was no significant difference between HD and RTRs; however, osteoporosis rate was significantly lower in control subjects. BMD measurements (femur and lumbar T- and Z-scores) were comparable between HD and RTR groups. Control group DEXA values were similar to RTRs; however, they were significantly higher compared to HD group. 25(OH) vitamin D levels were comparable between the HD and RTR groups, and these were significantly lower compared to values of the control group. Mean serum irisin level was 426.6 ± 191.2 pg/mL in hemodialysis group, 342.6 ± 174.8 in the RTR group, and 208.0 ± 186.1 in controls. Serum irisin levels were similar in RTR and HD groups, but their values were significantly higher compared to controls. When we compared serum irisin levels between patients with and without osteoporosis in the whole cohort and hemodialysis and RTR groups, there was no difference. Serum irisin was positively correlated with lumbar T-score both in hemodialysis and RTR groups.
Conclusion
Our study is the first in the literature revealing the positive correlation of serum irisin level with femur T-score in RTRs. Serum irisin level was also positively correlated with femur T-scores in hemodialysis patients.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-023-03475-7</identifier><identifier>PMID: 36773217</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Body mass index ; Bone Density ; Bone Diseases, Metabolic - etiology ; Bone mineral density ; C-reactive protein ; Calcium ; Calcium metabolism ; Creatinine ; Cross-Sectional Studies ; Dual energy X-ray absorptiometry ; Femur ; Ferritin ; Fibronectins ; Glomerular filtration rate ; Hemodialysis ; Humans ; Kidney diseases ; Kidney Transplantation ; Kidney transplants ; Medicine ; Medicine & Public Health ; Nephrology ; Nephrology - Original Paper ; Osteopenia ; Osteoporosis ; Osteoporosis - etiology ; Renal Dialysis ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - therapy ; Urology ; Vitamin D</subject><ispartof>International urology and nephrology, 2023-07, Vol.55 (7), p.1821-1828</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-7d33e9e6445bcd059d017a3cce70e441a681c9ac9d4fc68181ce513cf7e122bb3</cites><orcidid>0000-0001-7459-3636</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-023-03475-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-023-03475-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36773217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demir, Canan</creatorcontrib><creatorcontrib>Dursun, Ali Doğan</creatorcontrib><creatorcontrib>Sarıyıldız, Gülçin Türkmen</creatorcontrib><creatorcontrib>Arslan, Aykut İlker</creatorcontrib><title>Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Aim
To elucidate the association of serum irisin levels with bone mineral density (BMD) and calcium–phosphorus metabolism parameters in chronic kidney disease (CKD) patients and renal transplant recipients (RTRs).
Methods
This is a cross-sectional study involving CKD patients and RTRs. Healthy volunteers served as controls. Age, gender, and dialysis vintage were recorded. Serum irisin, creatinine, glucose, calcium, albumin, 25(OH) vitamin D, ferritin, C-reactive protein, A1C, and lipid profile were studied in all participants. Estimated glomerular filtration rate (eGFR), corrected calcium, and body mass index (BMI) were calculated.
Results
Overall, 49 patients (23 hemodialysis, 26 RTRs) and 25 control subjects were included. In hemodialysis (HD) group, 8 patients (34.8%) had osteoporosis, and 12 patients (52.2%) had osteopenia. In RTR group, 3 patients (11.5%) had osteoporosis, while 15 patients (57.7%) had osteopenia. Among controls, one had osteoporosis, and 7 had osteopenia. There was no significant difference between HD and RTRs; however, osteoporosis rate was significantly lower in control subjects. BMD measurements (femur and lumbar T- and Z-scores) were comparable between HD and RTR groups. Control group DEXA values were similar to RTRs; however, they were significantly higher compared to HD group. 25(OH) vitamin D levels were comparable between the HD and RTR groups, and these were significantly lower compared to values of the control group. Mean serum irisin level was 426.6 ± 191.2 pg/mL in hemodialysis group, 342.6 ± 174.8 in the RTR group, and 208.0 ± 186.1 in controls. Serum irisin levels were similar in RTR and HD groups, but their values were significantly higher compared to controls. When we compared serum irisin levels between patients with and without osteoporosis in the whole cohort and hemodialysis and RTR groups, there was no difference. Serum irisin was positively correlated with lumbar T-score both in hemodialysis and RTR groups.
Conclusion
Our study is the first in the literature revealing the positive correlation of serum irisin level with femur T-score in RTRs. Serum irisin level was also positively correlated with femur T-scores in hemodialysis patients.</description><subject>Body mass index</subject><subject>Bone Density</subject><subject>Bone Diseases, Metabolic - etiology</subject><subject>Bone mineral density</subject><subject>C-reactive protein</subject><subject>Calcium</subject><subject>Calcium metabolism</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Femur</subject><subject>Ferritin</subject><subject>Fibronectins</subject><subject>Glomerular filtration rate</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Osteopenia</subject><subject>Osteoporosis</subject><subject>Osteoporosis - etiology</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Urology</subject><subject>Vitamin D</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1P3DAQhi0E4qv9Az1Ulrj0kuKPOE5OFUKFVkLiAD1bXnuWNc3aqSdZxL_Hu0sp5cDJY887z3jmJeQTZ185Y_oUORdKVUzIislaq0rvkEOutKyEauvdV_EBOUK8Z4x1LWP75EA2WkvB9SGZbiBPSxpywBBpDyvokdroacIR0pBywoC0pAY7Bogj0ocwLqj1KxsdeOoWOcXg6O_gIzxSHxAswoaQIdqejtlGHHobx_LgwrCBfCB7c9sjfHw-j8mvi--35z-qq-vLn-dnV5WrRTNW2ksJHTR1rWbOM9V5xrWVzoFmUNfcNi13nXWdr-euxOUGiks318CFmM3kMfm25Q7TbAneld7Z9mbIYWnzo0k2mP8zMSzMXVoZzkQny5YK4cszIac_E-BolgEd9GUgSBMaobVqBNNNU6Qnb6T3acplB0XVik61neJroNiqXFktZpi__IYzs7bVbG01xVazsdWsiz6_nuOl5K-PRSC3AiypeAf5X-93sE-fkrD4</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Demir, Canan</creator><creator>Dursun, Ali Doğan</creator><creator>Sarıyıldız, Gülçin Türkmen</creator><creator>Arslan, Aykut İlker</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7459-3636</orcidid></search><sort><creationdate>20230701</creationdate><title>Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients</title><author>Demir, Canan ; Dursun, Ali Doğan ; Sarıyıldız, Gülçin Türkmen ; Arslan, Aykut İlker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-7d33e9e6445bcd059d017a3cce70e441a681c9ac9d4fc68181ce513cf7e122bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Body mass index</topic><topic>Bone Density</topic><topic>Bone Diseases, Metabolic - etiology</topic><topic>Bone mineral density</topic><topic>C-reactive protein</topic><topic>Calcium</topic><topic>Calcium metabolism</topic><topic>Creatinine</topic><topic>Cross-Sectional Studies</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Femur</topic><topic>Ferritin</topic><topic>Fibronectins</topic><topic>Glomerular filtration rate</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Transplantation</topic><topic>Kidney transplants</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Osteopenia</topic><topic>Osteoporosis</topic><topic>Osteoporosis - etiology</topic><topic>Renal Dialysis</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Urology</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demir, Canan</creatorcontrib><creatorcontrib>Dursun, Ali Doğan</creatorcontrib><creatorcontrib>Sarıyıldız, Gülçin Türkmen</creatorcontrib><creatorcontrib>Arslan, Aykut İlker</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demir, Canan</au><au>Dursun, Ali Doğan</au><au>Sarıyıldız, Gülçin Türkmen</au><au>Arslan, Aykut İlker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>55</volume><issue>7</issue><spage>1821</spage><epage>1828</epage><pages>1821-1828</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Aim
To elucidate the association of serum irisin levels with bone mineral density (BMD) and calcium–phosphorus metabolism parameters in chronic kidney disease (CKD) patients and renal transplant recipients (RTRs).
Methods
This is a cross-sectional study involving CKD patients and RTRs. Healthy volunteers served as controls. Age, gender, and dialysis vintage were recorded. Serum irisin, creatinine, glucose, calcium, albumin, 25(OH) vitamin D, ferritin, C-reactive protein, A1C, and lipid profile were studied in all participants. Estimated glomerular filtration rate (eGFR), corrected calcium, and body mass index (BMI) were calculated.
Results
Overall, 49 patients (23 hemodialysis, 26 RTRs) and 25 control subjects were included. In hemodialysis (HD) group, 8 patients (34.8%) had osteoporosis, and 12 patients (52.2%) had osteopenia. In RTR group, 3 patients (11.5%) had osteoporosis, while 15 patients (57.7%) had osteopenia. Among controls, one had osteoporosis, and 7 had osteopenia. There was no significant difference between HD and RTRs; however, osteoporosis rate was significantly lower in control subjects. BMD measurements (femur and lumbar T- and Z-scores) were comparable between HD and RTR groups. Control group DEXA values were similar to RTRs; however, they were significantly higher compared to HD group. 25(OH) vitamin D levels were comparable between the HD and RTR groups, and these were significantly lower compared to values of the control group. Mean serum irisin level was 426.6 ± 191.2 pg/mL in hemodialysis group, 342.6 ± 174.8 in the RTR group, and 208.0 ± 186.1 in controls. Serum irisin levels were similar in RTR and HD groups, but their values were significantly higher compared to controls. When we compared serum irisin levels between patients with and without osteoporosis in the whole cohort and hemodialysis and RTR groups, there was no difference. Serum irisin was positively correlated with lumbar T-score both in hemodialysis and RTR groups.
Conclusion
Our study is the first in the literature revealing the positive correlation of serum irisin level with femur T-score in RTRs. Serum irisin level was also positively correlated with femur T-scores in hemodialysis patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>36773217</pmid><doi>10.1007/s11255-023-03475-7</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7459-3636</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International urology and nephrology, 2023-07, Vol.55 (7), p.1821-1828 |
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| language | eng |
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| source | MEDLINE; Springer Journals |
| subjects | Body mass index Bone Density Bone Diseases, Metabolic - etiology Bone mineral density C-reactive protein Calcium Calcium metabolism Creatinine Cross-Sectional Studies Dual energy X-ray absorptiometry Femur Ferritin Fibronectins Glomerular filtration rate Hemodialysis Humans Kidney diseases Kidney Transplantation Kidney transplants Medicine Medicine & Public Health Nephrology Nephrology - Original Paper Osteopenia Osteoporosis Osteoporosis - etiology Renal Dialysis Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - therapy Urology Vitamin D |
| title | Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients |
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